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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The Dlk1 and Gtl2 genes are linked and reciprocally imprinted.

Genes subject to genomic imprinting exist in large chromosomal domains, probably reflecting coordinate regulation of the genes within a cluster. Such regulation has been demonstrated for the H19, Igf2, and Ins2 genes that share a bifunctional imprinting control region. We have identified the Dlk1 gene as a new imprinted gene that is paternally expressed. Furthermore, we show that Dlk1 is tightly linked to the maternally expressed Gtl2 gene. Dlk1 and Gtl2 are coexpressed and respond in a reciprocal manner to loss of DNA methylation. These genes are likely to represent a new example of coordinated imprinting of linked genes.[1]

References

  1. The Dlk1 and Gtl2 genes are linked and reciprocally imprinted. Schmidt, J.V., Matteson, P.G., Jones, B.K., Guan, X.J., Tilghman, S.M. Genes Dev. (2000) [Pubmed]
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