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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Pentacyclic triterpenoids from Freziera sp. that inhibit DNA polymerase beta.

In a survey of crude plant extracts for DNA polymerase 1 inhibitors, a methyl ethyl ketone extract prepared from Freziera sp. exhibited potent inhibition of DNA polymerase beta. Bioassay-guided fractionation of the extract, guided by an assay to detect DNA polymerase beta inhibition, resulted in the isolation of six active pentacyclic triterpenoids (1-6). These triterpenoids had IC50 values ranging from 7.5 to 16 microM in the presence of bovine serum albumin ( BSA) and 2.6-5.8 microM in the absence of BSA, consistent with the possibility that these inhibitors may be of use in vivo.[1]


  1. Pentacyclic triterpenoids from Freziera sp. that inhibit DNA polymerase beta. Deng, J.Z., Starck, S.R., Hecht, S.M. Bioorg. Med. Chem. (2000) [Pubmed]
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