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Gene Review

POLB  -  polymerase (DNA directed), beta

Homo sapiens

Synonyms: DNA polymerase beta
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Disease relevance of POLB


High impact information on POLB


Chemical compound and disease context of POLB


Biological context of POLB


Anatomical context of POLB


Associations of POLB with chemical compounds


Physical interactions of POLB


Enzymatic interactions of POLB


Co-localisations of POLB

  • The kinetoplast structure-specific endonuclease I is related to the 5' exo/endonuclease domain of bacterial DNA polymerase I and colocalizes with the kinetoplast topoisomerase II and DNA polymerase beta during replication [33].

Regulatory relationships of POLB


Other interactions of POLB


Analytical, diagnostic and therapeutic context of POLB


  1. Recurrent homogeneously staining regions in 8p1 in breast cancer and lack of amplification of POLB, LHRH, and PLAT genes. Saint-Ruf, C., Gerbault-Seureau, M., Viegas-Péquignot, E., Zafrani, B., Malfoy, B., Dutrillaux, B. Cancer Genet. Cytogenet. (1991) [Pubmed]
  2. Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme. Abbotts, J., SenGupta, D.N., Zmudzka, B., Widen, S.G., Notario, V., Wilson, S.H. Biochemistry (1988) [Pubmed]
  3. DNA polymerase beta mutations in human colorectal cancer. Wang, L., Patel, U., Ghosh, L., Banerjee, S. Cancer Res. (1992) [Pubmed]
  4. DNA polymerase beta gene mutations in human bladder cancer. Matsuzaki, J., Dobashi, Y., Miyamoto, H., Ikeda, I., Fujinami, K., Shuin, T., Kubota, Y. Mol. Carcinog. (1996) [Pubmed]
  5. Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan. Friedman, H.S., Dolan, M.E., Kaufmann, S.H., Colvin, O.M., Griffith, O.W., Moschel, R.C., Schold, S.C., Bigner, D.D., Ali-Osman, F. Cancer Res. (1994) [Pubmed]
  6. XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. Whitehouse, C.J., Taylor, R.M., Thistlethwaite, A., Zhang, H., Karimi-Busheri, F., Lasko, D.D., Weinfeld, M., Caldecott, K.W. Cell (2001) [Pubmed]
  7. Arginine methylation regulates DNA polymerase beta. El-Andaloussi, N., Valovka, T., Toueille, M., Steinacher, R., Focke, F., Gehrig, P., Covic, M., Hassa, P.O., Schär, P., Hübscher, U., Hottiger, M.O. Mol. Cell (2006) [Pubmed]
  8. AP endonuclease-independent DNA base excision repair in human cells. Wiederhold, L., Leppard, J.B., Kedar, P., Karimi-Busheri, F., Rasouli-Nia, A., Weinfeld, M., Tomkinson, A.E., Izumi, T., Prasad, R., Wilson, S.H., Mitra, S., Hazra, T.K. Mol. Cell (2004) [Pubmed]
  9. Acetylation regulates the DNA end-trimming activity of DNA polymerase beta. Hasan, S., El-Andaloussi, N., Hardeland, U., Hassa, P.O., Bürki, C., Imhof, R., Schär, P., Hottiger, M.O. Mol. Cell (2002) [Pubmed]
  10. Elevated expression of DNA polymerase beta gene in glioma cell lines with acquired resistance to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea. Gomi, A., Shinoda, S., Sakai, R., Hirai, H., Ozawa, K., Masuzawa, T. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  11. Impaired DNA repair via the base-excision repair pathway after focal ischemic brain injury: a protein phosphorylation-dependent mechanism reversed by hypothermic neuroprotection. Luo, Y., Ji, X., Ling, F., Li, W., Zhang, F., Cao, G., Chen, J. Front. Biosci. (2007) [Pubmed]
  12. Replication of adenovirus DNA-protein complex with purified proteins. Ikeda, J.E., Enomoto, T., Hurwitz, J. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  13. On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine. Allaudeen, H.S., Kozarich, J.W., Bertino, J.R., De Clercq, E. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  14. Mutation analysis of 8p genes POLB and PPP2CB in bladder cancer. Eydmann, M.E., Knowles, M.A. Cancer Genet. Cytogenet. (1997) [Pubmed]
  15. A survey of splice variants of the human hypoxanthine phosphoribosyl transferase and DNA polymerase beta genes: products of alternative or aberrant splicing? Skandalis, A., Uribe, E. Nucleic Acids Res. (2004) [Pubmed]
  16. Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein. Kubota, Y., Nash, R.A., Klungland, A., Schär, P., Barnes, D.E., Lindahl, T. EMBO J. (1996) [Pubmed]
  17. A novel nuclear protein, MGC5306 interacts with DNA polymerase beta and has a potential role in cellular phenotype. Wang, L., Bhattacharyya, N., Chelsea, D.M., Escobar, P.F., Banerjee, S. Cancer Res. (2004) [Pubmed]
  18. A variant of DNA polymerase beta acts as a dominant negative mutant. Bhattacharyya, N., Banerjee, S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  19. Variations of DNA polymerase-alpha and -beta during prolonged stimulation of human lymphocytes. Bertazzoni, U., Stefanini, M., Noy, G.P., Giulotto, E., Nuzzo, F., Falaschi, A., Spadari, S. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  20. Heat-shock proteins associated with base excision repair enzymes in HeLa cells. Mendez, F., Sandigursky, M., Franklin, W.A., Kenny, M.K., Kureekattil, R., Bases, R. Radiat. Res. (2000) [Pubmed]
  21. Heterogeneity in the radiation survival curves and biochemical properties of human lung cancer cell lines. Morstyn, G., Russo, A., Carney, D.N., Karawya, E., Wilson, S.H., Mitchell, J.B. J. Natl. Cancer Inst. (1984) [Pubmed]
  22. Elongation of primed DNA templates by eukaryotic DNA polymerases. Ikeda, J.E., Longiaru, M., Horwitz, M.S., Hurwitz, J. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  23. Base excision repair in nucleosomes lacking histone tails. Beard, B.C., Stevenson, J.J., Wilson, S.H., Smerdon, M.J. DNA Repair (Amst.) (2005) [Pubmed]
  24. Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity. Beard, W.A., Shock, D.D., Yang, X.P., DeLauder, S.F., Wilson, S.H. J. Biol. Chem. (2002) [Pubmed]
  25. Repair of clustered DNA lesions. Sequence-specific inhibition of long-patch base excision repair be 8-oxoguanine. Budworth, H., Dianova, I.I., Podust, V.N., Dianov, G.L. J. Biol. Chem. (2002) [Pubmed]
  26. Excision of C-4'-oxidized deoxyribose lesions from double-stranded DNA by human apurinic/apyrimidinic endonuclease (Ape1 protein) and DNA polymerase beta. Xu, Y.J., Kim, E.Y., Demple, B. J. Biol. Chem. (1998) [Pubmed]
  27. Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone. DeMott, M.S., Beyret, E., Wong, D., Bales, B.C., Hwang, J.T., Greenberg, M.M., Demple, B. J. Biol. Chem. (2002) [Pubmed]
  28. Structure and function of mammalian DNA ligases. Tomkinson, A.E., Mackey, Z.B. Mutat. Res. (1998) [Pubmed]
  29. Regulation of WRN helicase activity in human base excision repair. Ahn, B., Harrigan, J.A., Indig, F.E., Wilson, D.M., Bohr, V.A. J. Biol. Chem. (2004) [Pubmed]
  30. The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair. Toueille, M., El-Andaloussi, N., Frouin, I., Freire, R., Funk, D., Shevelev, I., Friedrich-Heineken, E., Villani, G., Hottiger, M.O., Hübscher, U. Nucleic Acids Res. (2004) [Pubmed]
  31. Action of human apurinic endonuclease (Ape1) on C1'-oxidized deoxyribose damage in DNA. Xu, Y.J., DeMott, M.S., Hwang, J.T., Greenberg, M.M., Demple, B. DNA Repair (Amst.) (2003) [Pubmed]
  32. Efficiency of exonucleolytic action of apurinic/apyrimidinic endonuclease 1 towards matched and mismatched dNMP at the 3' terminus of different oligomeric DNA structures correlates with thermal stability of DNA duplexes. Dyrkheeva, N.S., Lomzov, A.A., Pyshnyi, D.V., Khodyreva, S.N., Lavrik, O.I. Biochim. Biophys. Acta (2006) [Pubmed]
  33. The kinetoplast structure-specific endonuclease I is related to the 5' exo/endonuclease domain of bacterial DNA polymerase I and colocalizes with the kinetoplast topoisomerase II and DNA polymerase beta during replication. Engel, M.L., Ray, D.S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  34. The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta. Harrigan, J.A., Wilson, D.M., Prasad, R., Opresko, P.L., Beck, G., May, A., Wilson, S.H., Bohr, V.A. Nucleic Acids Res. (2006) [Pubmed]
  35. DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis. Prasad, R., Lavrik, O.I., Kim, S.J., Kedar, P., Yang, X.P., Vande Berg, B.J., Wilson, S.H. J. Biol. Chem. (2001) [Pubmed]
  36. Repair of tandem base lesions in DNA by human cell extracts generates persisting single-strand breaks. Budworth, H., Matthewman, G., O'Neill, P., Dianov, G.L. J. Mol. Biol. (2005) [Pubmed]
  37. Biochemical characterization of a mitomycin C-resistant human bladder cancer cell line. Singh, S.V., Scalamogna, D., Xia, H., O'Toole, S., Roy, D., Emerson, E.O., Gupta, V., Zaren, H.A. Int. J. Cancer (1996) [Pubmed]
  38. Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase beta. Muftuoglu, M., Wong, H.K., Imam, S.Z., Wilson, D.M., Bohr, V.A., Opresko, P.L. Cancer Res. (2006) [Pubmed]
  39. Molecular mechanism of PCNA-dependent base excision repair. Matsumoto, Y. Prog. Nucleic Acid Res. Mol. Biol. (2001) [Pubmed]
  40. Regulatory roles of p21 and apurinic/apyrimidinic endonuclease 1 in base excision repair. Tom, S., Ranalli, T.A., Podust, V.N., Bambara, R.A. J. Biol. Chem. (2001) [Pubmed]
  41. Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1). Klungland, A., Lindahl, T. EMBO J. (1997) [Pubmed]
  42. A variant of DNA polymerase beta is not cancer specific. Bu, D., Cler, L.R., Lewis, C.M., Euhus, D.M. Journal of investigative surgery : the official journal of the Academy of Surgical Research. (2004) [Pubmed]
  43. Difference in expression level and localization of DNA polymerase beta among human esophageal cancer focus, adjacent and corresponding normal tissues. Dong, Z.M., Zheng, N.G., Wu, J.L., Li, S.K., Wang, Y.L. Dis. Esophagus (2006) [Pubmed]
  44. The DNA polymerase beta replication error spectrum in the adenomatous polyposis coli gene contains human colon tumor mutational hotspots. Muniappan, B.P., Thilly, W.G. Cancer Res. (2002) [Pubmed]
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