Disease relevance of Propione

• Delayed methyl ethyl ketone peroxide keratitis may cause exacerbations and remissions of corneal and limbal disease lasting more than 20 years with palpebral and bulbar hyperemia equal to the initial chemical exposure [1].
• Degradation characteristics of methyl ethyl ketone by Pseudomonas sp. KT-3 in liquid culture and biofilter [2].
• One of its well known applications is the formation of methyl ethyl ketone, by dehydration, which can be used as a liquid fuel additive [3].
• Contact sensitivity to methyl ethyl ketone peroxide in a paint sprayer [4].
• Contact urticaria from methyl ethyl ketone [5].

High impact information on Propione

• Blocking the MAPK pathway with the specific methyl ethyl ketone 1/2 inhibitor (U0126) completely neutralized the enhancement of cell proliferation induced by KGF and FGF-10 [6].
• A dramatic solvent effect was found in the hydrogenation of itaconates, which induces opposite chiralities of the product with the same catalytic system by the use of different solvents (e.g., 99.6% ee (R) in TFE vs 71.2% ee (S) in methyl ethyl ketone) [7].
• DRGN received serial dilutions of the AChE-specific inhibitor 1,5-bis-(4-allyldimethylammoniumphenyl) pentan-3-one dibromide (BW284c51) ranging from 10(-4) to 10(-7) M [8].
• Recoveries for nonanone, methyl ethyl ketone, and ethyl acetate were not optimized because they were present in very low concentrations in the popcorn processing facility and not considered to be major occupational health hazards [9].
• Unlike acetone, two other ketone-containing solvents, methyl ethyl ketone (2-butanone) and diethyl ketone (3-pentanone) failed to significantly enhance tolbutamide hydroxylation [10].

Chemical compound and disease context of Propione

• Patch testing showed a positive allergic reaction to only 5% triglycidyl isocyanurate in methyl ethyl ketone [11].

Biological context of Propione

• Peroxidative damage to DNA initiated by methyl ethyl ketone peroxide, a potent initiator of lipid peroxidation, and protection against this damage by vitamin E were studied in rats [12].
• Nocodazole, ethyl acetate, acetone and methyl ethyl ketone all are known to induce aneuploidy [13].
• In essence, this study suggests that MCS is associated with increased nasal airflow resistance, respiration rate, heart rate, and scores on the Beck Depression Inventory, but not with significant changes in odor detection threshold sensitivity to phenyl ethyl alcohol and methyl ethyl ketone, the two target stimuli evaluated [14].
• LORs >3.50 were found in men for occupational exposure to sulphur dioxide, xylene, methyl ethyl ketone, herbicides and in women for occupational exposure to lead, nitrous oxide and insecticides [15].
• Cytogenetic analysis of buccal cells from shoeworkers and pathology and anatomy laboratory workers exposed to n-hexane, toluene, methyl ethyl ketone and formaldehyde [16].

Anatomical context of Propione

• We have previously reported that dorsal root ganglion neurons cultured in the presence of the highly specific, reversible acetylcholinesterase inhibitor 1,5-bis-(4-allyldimethylammoniumphenyl) pentan-3-one dibromide (BW284c51), showed significantly reduced neurite outgrowth and contained massive perikaryal inclusions of neurofilaments [17].
• OBJECTIVES: To investigate the effects of an acute exposure to 200 ppm methyl ethyl ketone on the nasal mucosa of healthy volunteers [18].

Associations of Propione with other chemical compounds

• Cumene hydroperoxide and methyl ethyl ketone peroxide, but not hydrogen peroxide, damaged protein synthesis and induced lipid peroxidation [19].
• The observation after coexposure to methyl ethyl ketone or isopropyl alcohol at low concentration is in line with the negative interaction between toluene and methyl ethyl ketone as well as between toluene and isopropyl alcohol after occupational exposures at low concentrations [20].
• Critical analysis of Mitran et al. (1997). Neurotoxicity associated with occupational exposure to acetone. Methyl ethyl ketone, and cyclohexanone. Environ. Res. 73, 181-188 [21].
• We measured fluorescence quantum yields of acetone and 3-pentanone as a pure gas and with nitrogen diluent at room temperature at 20, 507, and 1013 mbar using 248, 266, and 308 nm excitation by calibrating the optical collection system with Rayleigh scattering from nitrogen [22].
• A case of coma due to the drinking of a liquid cement for polyvinyl chloride resin, containing acetone, methyl ethyl ketone, cyclohexanone and polyvinyl chloride is described [23].

Gene context of Propione

• The effects of other AChE inhibitors that bind the active and/or the peripheral site of the enzyme [paraoxon, eserine, or 1,5-bis(4-allyldimethylammoniumphenyl) pentan-3-one dibromide (BW284c51)] were also studied [24].
• At 20 mbar with 308-nm excitation, the fluorescence quantum yields for acetone and 3-pentanone are 7 +/- 1 x 10(-4) and 1.1 +/- 0.2 x 10(-3), respectively, and each decreases with decreasing excitation wavelength [22].
• A survey of crude plant extracts for DNA polymerase beta inhibitors resulted in the identification of a methyl ethyl ketone extract prepared from Knema elegans that strongly inhibited the enzyme [25].
• In a survey of crude plant extracts for DNA polymerase 1 inhibitors, a methyl ethyl ketone extract prepared from Freziera sp. exhibited potent inhibition of DNA polymerase beta [26].
• Among the catalysts, DBU was found to be the most effective promoter allowing the reaction to proceed smoothly at room temperature and to give the corresponding O-acyl cyanohydrin adducts in higher yields for a variety of substituted cyclohexanones, cyclopentanone, acetone or pentan-3-one and various acyl cyanides [27].

Analytical, diagnostic and therapeutic context of Propione

• More than 95% labeling efficiency was obtained on paper chromatography in saline and methyl ethyl ketone [28].
• A major factor in the severity of ocular injury was the length of time from exposure to methyl ethyl ketone peroxide to obtaining a topical ocular local anesthetic to perform adequate lavage [1].
• METHODS: Nineteen healthy non-smoking men were exposed to 200 ppm methyl ethyl ketone and to a sham exposure in an exposure chamber, using a cross-over design [18].
• Liberated iodine is reacted with 3-pentanone to form 2-iodo-3-pentanone, extracted into n-hexane, and then determined by gas chromatography with an electron-capture detector [29].

References