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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

A morphological basis for intercellular communication between alpha- and beta-cells in the endocrine pancreas.

By degranulating beta-cells in the islets of Langerhans of the rat with sulfonylurea, it has been possible to distinguish unambiguously alpha-cells from beta-cells in freeze-fracture replicas. In such preparations, we found morphologically typical tight and gap junctions occurring between alpha- and beta-cells. The presence of gap junctions offers indirect evidence that these cells are coupled with one another; coupling may influence the secretory behavior of alpha- and beta-cells maintaining glucose homeostasis within tightly constricted limits.[1]

References

  1. A morphological basis for intercellular communication between alpha- and beta-cells in the endocrine pancreas. Orci, L., Malaisse-Lagae, F., Ravazzola, M., Rouiller, D., Renold, A.E., Perrelet, A., Unger, R. J. Clin. Invest. (1975) [Pubmed]
 
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