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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Smooth-pursuit eye movements, and diazepam, CPZ, and secobarbital.

This study examined the effects on smooth-pursuit eye tracking of single doses of CPZ (0.667 and 1.334 mg/kg), diazepam (0.071, 0.142, and 0.284 mg/kg), and secobarbital (100 mg). Only the barbiturate significantly affected the ability to follow a moving target with smooth-pursuit eye movements. In repeated testing of a single subject, 130 mg of secobarbital disrupted smooth-pursuit movements at least until 24 hrs after ingestion.[1]


  1. Smooth-pursuit eye movements, and diazepam, CPZ, and secobarbital. Holzman, P.S., Levy, D.L., Uhlenhuth, E.H., Proctor, L.R., Freedman, D.X. Psychopharmacologia. (1975) [Pubmed]
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