The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Barbosec     5-[(2R)-pentan-2-yl]-5-prop- 2-enyl-1,3...

Synonyms: Hypotrol, Evronal, Hyptran, Somosal, Pramil, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of R(+)-Secobarbital


Psychiatry related information on R(+)-Secobarbital


High impact information on R(+)-Secobarbital


Chemical compound and disease context of R(+)-Secobarbital


Biological context of R(+)-Secobarbital


Anatomical context of R(+)-Secobarbital


Associations of R(+)-Secobarbital with other chemical compounds


Gene context of R(+)-Secobarbital

  • Modulation of the biphasic effect of muscimol on prolactin secretion by benzodiazepines and secobarbital was investigated, using an in vitro superfusion system [35].
  • Within-run and between-run precision were determined using three control samples (35, 100, and 250 ng/mL PCP; 0.4, 0.6, and 1.0 mg/L secobarbital) tested over a two-week period [36].
  • Secobarbital did not influence P300 amplitude [37].
  • Resting Cai was altered by all barbiturates tested except secobarbital and barbital, but not in a consistent manner, suggesting that the effect of barbiturates on resting Cai is not related either to their effects on NMDA receptor responses or to their behavioral effects [38].
  • The glutathione peroxidase activity decreased significantly on PCB administration and the secobarbital further decreased the activity [39].

Analytical, diagnostic and therapeutic context of R(+)-Secobarbital


  1. Barbiturates and lung cancer in humans. Friedman, G.D. J. Natl. Cancer Inst. (1981) [Pubmed]
  2. Time course of denervation of efferent sympathetic and vagal nerves after occlusion of the coronary artery in the canine heart. Inoue, H., Zipes, D.P. Circ. Res. (1988) [Pubmed]
  3. Interaction of secobarbital with warfarin pseudoracemates. O'Reilly, R.A., Trager, W.F., Motley, C.H., Howald, W. Clin. Pharmacol. Ther. (1980) [Pubmed]
  4. Secobarbital attenuates excitotoxicity but potentiates oxygen-glucose deprivation neuronal injury in cortical cell culture. Giffard, R.G., Weiss, J.H., Swanson, R.A., Choi, D.W. J. Cereb. Blood Flow Metab. (1993) [Pubmed]
  5. Radiosensitization of Staphylococcus aureus by secobarbital sodium and other barbiturates. Sade, N., Jacobs, G.P. Radiat. Res. (1983) [Pubmed]
  6. Effectiveness of intermediate-term use of secobarbital. Kales, A., Hauri, P., Bixler, E.O., Silberfarb, P. Clin. Pharmacol. Ther. (1976) [Pubmed]
  7. Effects of marihuana combined with secobarbital. Dalton, W.S., Martz, R., Lemberger, L., Rodda, B.E., Forney, R.B. Clin. Pharmacol. Ther. (1975) [Pubmed]
  8. Dose effects of secobarbital in a Sternberg memory scanning task. Williams, H.L., Rundell, O.H., Smith, L.T. Psychopharmacology (Berl.) (1981) [Pubmed]
  9. Effect of d-amphetamine, secobarbital, and marijuana on choice behavior: social versus nonsocial options. Heishman, S.J., Stitzer, M.L. Psychopharmacology (Berl.) (1989) [Pubmed]
  10. Influence of secobarbital and alpha-chloralose, and of vagal and sympathetic interruption, on left ventricular activation after acute coronary artery occlusion in the dog. Ruffy, R., Lovelace, D.E., Knoebel, S.B., Zipes, D.P. Circ. Res. (1981) [Pubmed]
  11. Secobarbital-mediated inactivation of cytochrome P450 2B1 and its active site mutants. Partitioning between heme and protein alkylation and epoxidation. He, K., He, Y.A., Szklarz, G.D., Halpert, J.R., Correia, M.A. J. Biol. Chem. (1996) [Pubmed]
  12. Common pathways of cytochrome P450 gene regulation by peroxisome proliferators and barbiturates in Bacillus megaterium ATCC14581. English, N., Hughes, V., Wolf, C.R. J. Biol. Chem. (1994) [Pubmed]
  13. Stereochemical aspects of warfarin drug interactions: use of a combined pharmacokinetic-pharmacodynamic model. Chan, E., McLachlan, A., O'Reilly, R., Rowland, M. Clin. Pharmacol. Ther. (1994) [Pubmed]
  14. Pharmacologic effects and abuse liability of bretazenil, diazepam, and alprazolam in humans. Busto, U., Kaplan, H.L., Zawertailo, L., Sellers, E.M. Clin. Pharmacol. Ther. (1994) [Pubmed]
  15. Chronic insomnia: effects of tryptophan, flurazepam, secobarbital, and placebo. Hartmann, E., Lindsley, J.G., Spinweber, C. Psychopharmacology (Berl.) (1983) [Pubmed]
  16. Efficacy and safety of midazolam and vesparax in treatment of sleep disorders. Fischbach, R. British journal of clinical pharmacology. (1983) [Pubmed]
  17. The blood-brain barrier in young spontaneously hypertensive rats. Mueller, S.M. Acta neurologica Scandinavica. (1982) [Pubmed]
  18. Melatonin for sleep EEG. Milstein, V., Small, J.G., Spencer, D.W. Clinical EEG (electroencephalography). (1998) [Pubmed]
  19. Dose-response studies on tolerance to multiple doses of secobarbital and methaqualone in a polydrug abuse population. Faulkner, T.P., Hayden, J.H., Mehta, C.M., Olson, D.A., Comstock, E.G. Clin. Toxicol. (1979) [Pubmed]
  20. Modulation of phencyclidine-sensitive ethidium binding to the Torpedo acetylcholine receptor: interaction of noncompetitive inhibitors with carbamylcholine and cobra alpha-toxin. Valenzuela, C.F., Kerr, J.A., Duvvuri, P., Johnson, D.A. Mol. Pharmacol. (1992) [Pubmed]
  21. Identification of the heme adduct and an active site peptide modified during mechanism-based inactivation of rat liver cytochrome P450 2B1 by secobarbital. He, K., Falick, A.M., Chen, B., Nilsson, F., Correia, M.A. Chem. Res. Toxicol. (1996) [Pubmed]
  22. Smooth-pursuit eye movements, and diazepam, CPZ, and secobarbital. Holzman, P.S., Levy, D.L., Uhlenhuth, E.H., Proctor, L.R., Freedman, D.X. Psychopharmacologia. (1975) [Pubmed]
  23. Gas chromatographic assay for free and total plasma levels of thiopental. Becker, K.E. Anesthesiology (1976) [Pubmed]
  24. Post mortem kinetics of secobarbital. Quatrehomme, G., Bourret, F., Zhioua, M., Lapalus, P., Ollier, A. Forensic Sci. Int. (1990) [Pubmed]
  25. The contractile responses of isolated dog cerebral and extracerebral arteries to oxybarbiturates and thiobarbiturates. Hatano, Y., Nakamura, K., Moriyama, S., Mori, K., Toda, N. Anesthesiology (1989) [Pubmed]
  26. Secretion of drugs by the parotid glands of rats and human beings. Di Gregorio, G.J., Piraino, A.J., Nagle, B.T., Knaiz, E.K. J. Dent. Res. (1977) [Pubmed]
  27. Potential of liquid membranes for drug overdose treatment: in vitro studies. Chiang, C.W., Fuller, G.C., Frankenfeld, J.W., Rhodes, C.T. Journal of pharmaceutical sciences. (1978) [Pubmed]
  28. Induction of CYP1A2 by phenobarbital in the livers of aryl hydrocarbon-responsive and -nonresponsive mice. Sakuma, T., Ohtake, M., Katsurayama, Y., Jarukamjorn, K., Nemoto, N. Drug Metab. Dispos. (1999) [Pubmed]
  29. Fast and slow skeletal muscles: effect of secobarbital on contractility of muscles from mice. Taylor, R.G., Abresch, R.T., Lieberman, J.S., Fowler, W.M. Archives of physical medicine and rehabilitation. (1980) [Pubmed]
  30. Mechanism of false-negative urine cannabinoid immunoassay screens by Visine eyedrops. Pearson, S.D., Ash, K.O., Urry, F.M. Clin. Chem. (1989) [Pubmed]
  31. EEG correlates of impaired attention performance under secobarbital and chlorpromazine in the monkey. Mirsky, A.F., Tecce, J.J., Harman, N., Oshima, H. Psychopharmacologia. (1975) [Pubmed]
  32. Effects of phencyclidine, secobarbital and diazepam on eye tracking in rhesus monkeys. Ando, K., Johanson, C.E., Levy, D.L., Yasillo, N.J., Holzman, P.S., Schuster, C.R. Psychopharmacology (Berl.) (1983) [Pubmed]
  33. Quantitative electroencephalographic profile of 3-(4-hydroxy-1-piperidinyl)-6-(2,4-dichlorophenyl)-pyridazine (SR 41378) in the rat. Santucci, V., Rocher, D., Veyrun, J., Bizière, K. Naunyn Schmiedebergs Arch. Pharmacol. (1986) [Pubmed]
  34. Occurrence and fate of barbiturates in the aquatic environment. Peschka, M., Eubeler, J.P., Knepper, T.P. Environ. Sci. Technol. (2006) [Pubmed]
  35. Benzodiazepine- and barbiturate-interactions with GABAA receptor responses on lactotrophs. Anderson, R.A., Mitchell, R. Brain Res. (1986) [Pubmed]
  36. Abbott phencyclidine and barbiturates abused drug assays: evaluation and comparison of ADx FPIA, TDx FPIA, EMIT, and GC/MS methods. Caplan, Y.H., Levine, B. Journal of analytical toxicology. (1989) [Pubmed]
  37. Biological determinants of P300: the effects of a barbiturate on latency and amplitude. Fowler, B., Mitchell, I. Biological psychology. (1997) [Pubmed]
  38. Effect of anesthetic and convulsant barbiturates on N-methyl-D-aspartate receptor-mediated calcium flux in brain membrane vesicles. Daniell, L.C. Pharmacology (1994) [Pubmed]
  39. Effect of the degradation of cytochrome P-450 heme by secobarbital on polychlorinated biphenyls (PCB)-induced hepatic vitamin A reduction and lipid peroxide formation in rats. Saito, M., Ikegami, S., Aizawa, T., Innami, S. J. Nutr. Sci. Vitaminol. (1983) [Pubmed]
  40. Effect of secobarbital and morphine on arterial blood gases in healthy human volunteers. Zsigmond, E.K., Flynn, K. Journal of clinical pharmacology. (1993) [Pubmed]
  41. Metabolic and endocrine responses to surgery during caudal analgesia in children. Nakamura, T., Takasaki, M. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (1991) [Pubmed]
  42. Effects of Stealth adulterant on immunoassay testing for drugs of abuse. Cody, J.T., Valtier, S. Journal of analytical toxicology. (2001) [Pubmed]
WikiGenes - Universities