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MeSH Review

Pursuit, Smooth

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Disease relevance of Pursuit, Smooth


Psychiatry related information on Pursuit, Smooth


High impact information on Pursuit, Smooth

  • In SCA3, gaze-evoked nystagmus was often present as was saccade hypometria and smooth pursuit gain was markedly decreased [9].
  • No major improvement in smooth pursuit gain could be attributed to drug treatment, based on a comparison of patient results before and after administration of levodopa [10].
  • Peak velocity gain of smooth pursuit and performance on the Wisconsin Card Sort Test did not differ significantly between the two groups [11].
  • We conclude that V5 is directly related to the maintenance of an optimal smooth pursuit velocity during visual feedback, whereas the FEF, PFC, angular gyrus and PIVC are involved in reconstitution and prediction whenever SPV decreases, especially during maintenance of smooth pursuit in the absence of a visual target [12].
  • Patients with FA showed a characteristic combination of frequent saccadic intrusions, especially ocular flutter, relatively preserved optokinetic nystagmus (OKN) and smooth pursuit, and impaired vestibulo-ocular reflex (VOR) responses [13].

Chemical compound and disease context of Pursuit, Smooth


Biological context of Pursuit, Smooth


Anatomical context of Pursuit, Smooth

  • CONCLUSIONS: Neurodegeneration may not only affect the cranial nerve nuclei (i.e., oculomotor and abducens nuclei) of SCA-1, SCA-2 and SCA-3 patients integrated into the circuits, subserving accuracy of horizontal saccades and the generation of horizontal smooth pursuits, but likewise involves the premotor networks of these circuits [21].

Associations of Pursuit, Smooth with chemical compounds


Gene context of Pursuit, Smooth

  • This may explain why the SCA-1, SCA-2, and SCA-3 patients in this study with a heavily damaged reticulotegmental nucleus of the pons developed dysmetric horizontal saccades and impaired smooth pursuits during the course of the disease [21].
  • Here we report an association between the Ser9Gly polymorphism of the DRD3 gene and the intensity of eye movement disturbances (fixation and smooth pursuit) observed in 119 schizophrenic patients and in 94 unrelated healthy control subjects [27].
  • Schizophrenic children exhibited significantly greater smooth pursuit impairments than either normal or ADHD subjects [28].
  • Here we report an association between the BAN I polymorphism of the cytosolic PLA2 gene (single nucleotide polymorphism in the first intron of the gene) and the intensity of eye movement disturbances (fixation and smooth pursuit) observed in 126 schizophrenic patients [29].
  • Smooth pursuit gain and the error rate in the antisaccade paradigm were significantly correlated in the schizophrenia patients and the parents, whereas P50 inhibition showed no correlation with smooth pursuit gain or antisaccade paradigm measurements [17].

Analytical, diagnostic and therapeutic context of Pursuit, Smooth


  1. Ocular motor deficits in Parkinson's disease. II. Control of the saccadic and smooth pursuit systems. White, O.B., Saint-Cyr, J.A., Tomlinson, R.D., Sharpe, J.A. Brain (1983) [Pubmed]
  2. Molecular and clinical analyses of spinocerebellar ataxia type 8 in Japan. Ikeda, Y., Shizuka, M., Watanabe, M., Okamoto, K., Shoji, M. Neurology (2000) [Pubmed]
  3. Specific oculomotor deficit after diazepam. II. Smooth pursuit eye movements. Rothenberg, S.J., Selkoe, D. Psychopharmacology (Berl.) (1981) [Pubmed]
  4. Pharmacologic evidence for specificity of pursuit dysfunction to schizophrenia. Lithium carbonate associated with abnormal pursuit. Levy, D.L., Dorus, E., Shaughnessy, R., Yasillo, N.J., Pandey, G.N., Janicak, P.G., Gibbons, R.D., Gaviria, M., Davis, J.M. Arch. Gen. Psychiatry (1985) [Pubmed]
  5. Voluntary oculomotor performance upon awakening after total sleep deprivation. Ferrara, M., De Gennaro MFL, n.u.l.l., Bertini, M. Sleep. (2000) [Pubmed]
  6. The association between lithium carbonate and smooth pursuit eye tracking among first-episode patients with psychotic affective disorders. Gooding, D.C., Iacono, W.G., Katsanis, J., Beiser, M., Grove, W.M. Psychophysiology. (1993) [Pubmed]
  7. Eye movement and neuropsychological studies in first-degree relatives of schizophrenic patients. Rybakowski, J.K., Borkowska, A. Schizophr. Res. (2002) [Pubmed]
  8. Acute effects of bromazepam on signal detection performance, digit symbol substitution test and smooth pursuit eye movements. Jansen, A.A., Verbaten, M.N., Slangen, J.L. Neuropsychobiology (1988) [Pubmed]
  9. Eye movement abnormalities correlate with genotype in autosomal dominant cerebellar ataxia type I. Rivaud-Pechoux, S., Dürr, A., Gaymard, B., Cancel, G., Ploner, C.J., Agid, Y., Brice, A., Pierrot-Deseilligny, C. Ann. Neurol. (1998) [Pubmed]
  10. Abnormalities of smooth eye and head movement control in Parkinson's disease. Waterston, J.A., Barnes, G.R., Grealy, M.A., Collins, S. Ann. Neurol. (1996) [Pubmed]
  11. Oculomotor function in amyotrophic lateral sclerosis: evidence for frontal impairment. Shaunak, S., Orrell, R.W., O'Sullivan, E., Hawken, M.B., Lane, R.J., Henderson, L., Kennard, C. Ann. Neurol. (1995) [Pubmed]
  12. Parametric modulation of cortical activation during smooth pursuit with and without target blanking. an fMRI study. Nagel, M., Sprenger, A., Zapf, S., Erdmann, C., Kömpf, D., Heide, W., Binkofski, F., Lencer, R. Neuroimage (2006) [Pubmed]
  13. Comparison of oculomotor findings in the progressive ataxia syndromes. Moschner, C., Perlman, S., Baloh, R.W. Brain (1994) [Pubmed]
  14. Effects of antisocial personality, cocaine and opioid dependence, and gender on eye movement control. Ceballos, N.A., Bauer, L.O. Psychological reports. (2004) [Pubmed]
  15. Effect of alcohol and marijuana on eye movements. Baloh, R.W., Sharma, S., Moskowitz, H., Griffith, R. Aviation, space, and environmental medicine. (1979) [Pubmed]
  16. Relationship between a GABAA alpha 6 Pro385Ser substitution and benzodiazepine sensitivity. Iwata, N., Cowley, D.S., Radel, M., Roy-Byrne, P.P., Goldman, D. The American journal of psychiatry. (1999) [Pubmed]
  17. A concordance study of three electrophysiological measures in schizophrenia. Louchart-de la Chapelle, S., Nkam, I., Houy, E., Belmont, A., Ménard, J.F., Roussignol, A.C., Siwek, O., Mezerai, M., Guillermou, M., Fouldrin, G., Levillain, D., Dollfus, S., Campion, D., Thibaut, F. The American journal of psychiatry. (2005) [Pubmed]
  18. Dissociation of smooth pursuit and vestibulo-ocular reflex cancellation in SCA-6. Takeichi, N., Fukushima, K., Sasaki, H., Yabe, I., Tashiro, K., Inuyama, Y. Neurology (2000) [Pubmed]
  19. Retinotopic and directional deficits of smooth pursuit initiation after posterior cerebral hemispheric lesions. Morrow, M.J., Sharpe, J.A. Neurology (1993) [Pubmed]
  20. Role of the cerebellar flocculus region in the coordination of eye and head movements during gaze pursuit. Belton, T., McCrea, R.A. J. Neurophysiol. (2000) [Pubmed]
  21. Damage to the reticulotegmental nucleus of the pons in spinocerebellar ataxia type 1, 2, and 3. Rüb, U., Bürk, K., Schöls, L., Brunt, E.R., de Vos, R.A., Diaz, G.O., Gierga, K., Ghebremedhin, E., Schultz, C., Del Turco, D., Mittelbronn, M., Auburger, G., Deller, T., Braak, H. Neurology (2004) [Pubmed]
  22. Effects of ketamine on leading saccades during smooth-pursuit eye movements may implicate cerebellar dysfunction in schizophrenia. Avila, M.T., Weiler, M.A., Lahti, A.C., Tamminga, C.A., Thaker, G.K. The American journal of psychiatry. (2002) [Pubmed]
  23. Effects of nicotine on hippocampal and cingulate activity during smooth pursuit eye movement in schizophrenia. Tanabe, J., Tregellas, J.R., Martin, L.F., Freedman, R. Biol. Psychiatry (2006) [Pubmed]
  24. A comparison of the sensitivities of adaptive tracking, eye movement analysis and visual analog lines to the effects of incremental doses of temazepam in healthy volunteers. van Steveninck, A.L., Schoemaker, H.C., Pieters, M.S., Kroon, R., Breimer, D.D., Cohen, A.F. Clin. Pharmacol. Ther. (1991) [Pubmed]
  25. Smooth pursuit in twins before and after alcohol ingestion. Blekher, T., Miller, K., Yee, R.D., Christian, J.C., Abel, L.A. Invest. Ophthalmol. Vis. Sci. (1997) [Pubmed]
  26. The effect of apomorphine, MK-212 (6-chloro-2-[1-piperazinyl]-pyrazine) and placebo on smooth pursuit gain and corrective saccades in normal subjects. Friedman, L., Jesberger, J.A., Meltzer, H.Y. Neuropsychopharmacology (1994) [Pubmed]
  27. Dopamine D3 receptor (DRD3) gene polymorphism is associated with the intensity of eye movement disturbances in schizophrenic patients and healthy subjects. Rybakowski, J.K., Borkowska, A., Czerski, P.M., Hauser, J. Mol. Psychiatry (2001) [Pubmed]
  28. Smooth pursuit eye movements in childhood-onset schizophrenia: comparison with attention-deficit hyperactivity disorder and normal controls. Jacobsen, L.K., Hong, W.L., Hommer, D.W., Hamburger, S.D., Castellanos, F.X., Frazier, J.A., Giedd, J.N., Gordon, C.T., Karp, B.I., McKenna, K., Rapoport, J.L. Biol. Psychiatry (1996) [Pubmed]
  29. The study of cytosolic phospholipase A2 gene polymorphism in schizophrenia using eye movement disturbances as an endophenotypic marker. Rybakowski, J.K., Borkowska, A., Czerski, P.M., Dmitrzak-Weglarz, M., Hauser, J. Neuropsychobiology (2003) [Pubmed]
  30. Lorazepam-induced modifications of saccadic and smooth-pursuit eye movements in humans: attentional and motor factors. Masson, G.S., Mestre, D.R., Martineau, F., Soubrouillard, C., Brefel, C., Rascol, O., Blin, O. Behav. Brain Res. (2000) [Pubmed]
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