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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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SAGE analysis of neuroblastoma reveals a high expression of the human homologue of the Drosophila Delta gene.

BACKGROUND: Serial Analysis of Gene Expression (SAGE) is an efficient method to establish a complete mRNA expression profile of a tissue. PROCEDURE: We applied SAGE to identify expression of developmental control genes in neuroblastoma. Results. The human homologue of the Drosophila Delta gene Delta like-1 (DLK1) was shown to have an unusually high expression in a SAGE library of the SK-N-FI neuroblastoma cell line. Northern blot analysis confirmed high DLK1 expression in SK-N-FI and several other neuroblastoma cell lines. Signalling between Delta and its receptor Notch controls many differentiation steps in Drosophila and man, including neural crest cell fate decision. CONCLUSIONS: Our data therefore suggest a role for the Delta-Notch pathway in neuroblast differentiation.[1]

References

  1. SAGE analysis of neuroblastoma reveals a high expression of the human homologue of the Drosophila Delta gene. van Limpt, V., Chan, A., Caron, H., Sluis, P.V., Boon, K., Hermus, M.C., Versteeg, R. Med. Pediatr. Oncol. (2000) [Pubmed]
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