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Kawamoto, T. et al.

Association between favorable neuroblastoma and high expression of the novel metalloproteinase gene, nbla3145/ XCE, cloned by differential screening of the full-length-enriched oligo-capping neuroblastoma cDNA libraries.

BACKGROUND: The biology of neuroblastoma (NBL) is at least partly regulated by neurotrophic factors and their receptors. PROCEDURE: To identify novel NBL-related genes that affect growth, differentiation, and programmed cell death of the tumor, we constructed full-length-enriched cDNA libraries by oligo-capping method. RESULTS: Semi-quantitative and quantitative real-time RT-PCR showed that the nbla3145 gene was significantly highly expressed in favorable subset of NBL. The nucleo-tide sequence of nbla3145 revealed that it was a novel member of metalloproteinase, endothelin-converting enzyme, and was the same gene recently reported as XCE. We also cloned nbla3145beta which was a novel truncated form of nbla3145 (or nbla3145alpha). CONCLUSIONS: Our results suggested that nbla3145/ XCE plays an important role in regulating growth and differentiation of NBL.[1]

References

Association between favorable neuroblastoma and high expression of the novel metalloproteinase gene, nbla3145/XCE, cloned by differential screening of the full-length-enriched oligo-capping neuroblastoma cDNA libraries. Kawamoto, T., Shishikura, T., Ohira, M., Takayasu, H., Morohashi, A., Takada, N., Takahashi, M., Suzuki, Y., Sugano, S., Hori, T., Nakagawara, A. Med. Pediatr. Oncol. (2000) [Pubmed]

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