The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

OLIG1  -  oligodendrocyte transcription factor 1

Homo sapiens

Synonyms: BHLHB6, BHLHE21, Class B basic helix-loop-helix protein 6, Class E basic helix-loop-helix protein 21, Oligo1, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of OLIG1

 

Psychiatry related information on OLIG1

  • It was hypothesized a priori that OLIG2 and OLIG1 were associated with OCD regardless of the presence of comorbid Tourette disorder (TD), but not with TD alone [3].
  • Finally, the formation of oligodendrocytes is triggered by an increase in the activity of bHLH factors Olig1 and Olig2 that may be coupled with a decrease in Id activity [4].
  • To investigate this possibility, dietary patterns (7-d records), eating-disorders inventory (EDI), and BMD were examined in nine nonrunning eumenorrheic control (Contl) and 32 women runners classified as eumenorrheic (n = 19, Eumen) and oligo/amenorrheic (a group in which some were oligomenorrheic and some were amenorrheic; Ol/Am, n = 13) [5].
  • It appears that the oligo/amenorrhea noted in IDDM is principally hypothalamic in origin and may represent intermittent (and perhaps reversible) failure of the GnRH pulse generator, similar to the situation observed in women who engage in endurance training or who suffer from anorexia nervosa [6].
  • To isolate genes expressed in early human development, we constructed both oligo dT-primed and random hexamer-primed cDNA libraries from ten different tissues of human embryos aged 53 to 78 days post conception [7].
 

High impact information on OLIG1

  • Indeed, several NMR studies of oligo- and polynucleotides have been carried out to probe the structure and dynamics of nucleic acids in solution (for a review see ref. 1). The present study constitutes the first part of our attempt to assess the influence of non-complementary base pairs on the stability of nucleic acid double helices [8].
  • Hybridization of tumor DNA with immunoglobulin gene probes revealed that each lymphoma was oligo- or monoclonal in origin and that individual tumors from the same animal arose from different B-cell clones [9].
  • Isolation of the fluorescent hydrolysis product from acid hydrolyzates of oligo- and polydeoxyribonucleotides has shown that the photoadduct is formed by ultraviolet irradiation of d(pTpA), d(TpApT), d(TpApTpA), poly(dA-dT), and both single- and double-stranded DNA [10].
  • Recent reports show that Olig genes, which encode the basic helix-loop-helix Olig transcription factors, are essential for development of oligodendrocytes [11].
  • Surprisingly, Olig function is also required for formation of somatic motor neurons [11].
 

Chemical compound and disease context of OLIG1

 

Biological context of OLIG1

  • A very low level was detected in ependymomas, whereas other tumors lacked OLIG gene expression altogether [17].
  • In this study, we identified Zfp488, an oligodendrocyte-specific zinc-finger transcription regulator, by screening for genes downregulated in the optic nerves of Olig1-null mice [18].
  • To determine the effect of the length of the poly-(A) segment on human globin mRNA stability, 10 S globin mRNA was fractionated into poly-(A)-poor fractions by oligo (dT)-cellulose column chromatography [19].
  • The genome further specifies systems for scavenging of nutrients, particularly organic and inorganic nitrogen and oligo-elements, biofilm formation at the oil-water interface, biosurfactant production and niche-specific stress responses [20].
  • These results demonstrate that oligo-beta-glucosides must have a specific structure to trigger the signal transduction pathway, which ultimately leads to the de novo synthesis of phytoalexins in soybean [21].
 

Anatomical context of OLIG1

 

Associations of OLIG1 with chemical compounds

  • In the rodent central nervous system, they are expressed exclusively in oligodendrocytes and oligodendrocyte progenitors, and Olig1 can promote formation of an chondroitin sulfate proteoglycon-positive glial progenitor [25].
  • In 4 CD34(+) samples incubated for 3 days in cytokine-deficient conditions, cell apoptosis was reduced by more than 30% in the presence of amifostine (or amifostine plus a control oligo); the effect of amifostine was abolished in cultures with the decoy oligo [26].
  • Oligo 2'5' adenylate synthetase (2'5'As) induction, natural-killer (NK) cell activity, and T-cell subset distribution (heightened T helper/suppressor ratio) showed the most consistent treatment-associated changes and the greatest immunobiologic effects at dosages of 300 to 1,000 micrograms/m2 [27].
  • A 21-mer phosphorothioate-linked oligo DNA complementary to the HBV polyadenylation signal and 5'-upstream sequences was complexed to a targetable DNA carrier consisting of asialoglycoprotein coupled to polylysine [28].
  • The carbohydrate chains isolated from ESP-Sia were shown to consist of O-linked oligo/polysialic acid-containing glycan units and N-linked carbohydrate chains [29].
 

Physical interactions of OLIG1

  • Lamin B bound only oligo and poly(dG); no other nucleic acids tested were bound or could compete with the binding of oligo(dG) [30].
  • Crystallization and preliminary X-ray analysis of human platelet profilin complexed with an oligo proline peptide [31].
  • CASPER is an increment rule-based approach which uses chemical shifts of the free reducing monosaccharides which are altered according to attached residues of an oligo- or polysaccharide sequence [32].
 

Enzymatic interactions of OLIG1

  • Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase located in the cell nucleus which catalyses the polymerization of deoxynucleotides at the 3'hydroxyl ends of oligo- or polydeoxynucleotide initiators without a template [33].
  • Additionally, the RNA component of the oligo/ RNA duplex is efficiently cleaved by RNase H, the site of endonucleolytic cleavage being dictated by the length of the oligodeoxynucleoside phosphorothioate segment [34].
 

Regulatory relationships of OLIG1

  • To determine if the effects of uPAR are mediated through its ligand, monocytes were pre-treated with AS oligo to block uPA expression [35].
  • Co-incubation with p53 anti-sense oligo-nucleotide suppressed As(2)O(3)-induced intracellular p53 over-expression and apoptosis [36].
  • 5'SS RNA oligo-induced assembly of the multi-snRNP complex may thus serve as a model to study the mechanism of 5' splice site recognition during splicing [37].
  • Oligo I belongs to a class of active oligodeoxynucleotides that inhibits interferon-gamma-induced MHC Class I and ICAM-1 in K562 cells [38].
  • Improved Plasmodium falciparum cDNA expression libraries were constructed by combining mRNA oligo-capping with in vitro recombination and directional cloning of cDNA inserts into a plasmid vector that expresses sequences as thioredoxin fusion proteins [39].
 

Other interactions of OLIG1

  • Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation [22].
  • Thus, it involved enhanced expression of the oligodendrogenic transcription factors Olig1, Olig2, and Nkx2.2 and diminished expression of Id2, an inhibitor of oligodendrogenic differentiation [40].
  • Knockdown of cyclin B1 using an RNA interference oligo resulted in a slower cellular growth rate and an increase in resistance to paclitaxel [41].
  • Inhibition of p53 expression by using antisense oligo induced apoptosis upon heat shock in 3B4 cells [42].
  • Gastrin and CCKBR reverse transcription-polymerase chain reaction products were detected and verified by specific hybridisation with an oligo probe on Southern blots [43].
 

Analytical, diagnostic and therapeutic context of OLIG1

  • New oligodendrocytic lineage markers, such as OLIG1/2 gene, will probably help to define the real spectrum of oligodendroglial tumors, which may include a wide variety of tumors with very different prognoses [44].
  • The antibody depicted a single distinct band of predicted molecular weight by Western blotting, and did not cross-react with human Olig1 [45].
  • High OLIG expression alone has been proposed to distinguish oligodendrogliomas from astrocytomas, so we critically evaluated OLIG2 as a marker by immunohistochemical and oligonucleotide microarray analysis [46].
  • Expression of ECAC was found by immunofluorescence using characterized oligo-specific or monoclonal antibody: tamarin intestinal epithelium--but not lamina propria, muscularis mucosae, subserosa, or glycocalyx--demonstrated determinants of the ECAC antigen system [47].
  • The results of the biological assays established that the following structural motif is necessary for the oligo-beta-glucosides to have high elicitor activity: [formula; see text] The branched trisaccharide at the nonreducing end of the oligoglucosides was found to be essential for maximum elicitor activity [21].

References

  1. Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors. Azzarelli, B., Miravalle, L., Vidal, R. J. Neuropathol. Exp. Neurol. (2004) [Pubmed]
  2. Expression of the oligodendroglial lineage-associated markers Olig1 and Olig2 in different types of human gliomas. Ohnishi, A., Sawa, H., Tsuda, M., Sawamura, Y., Itoh, T., Iwasaki, Y., Nagashima, K. J. Neuropathol. Exp. Neurol. (2003) [Pubmed]
  3. A Genetic Family-Based Association Study of OLIG2 in Obsessive-compulsive Disorder. Stewart, S.E., Platko, J., Fagerness, J., Birns, J., Jenike, E., Smoller, J.W., Perlis, R., Leboyer, M., Delorme, R., Chabane, N., Rauch, S.L., Jenike, M.A., Pauls, D.L. Arch. Gen. Psychiatry (2007) [Pubmed]
  4. Basic helix-loop-helix factors in cortical development. Ross, S.E., Greenberg, M.E., Stiles, C.D. Neuron (2003) [Pubmed]
  5. Dietary patterns, eating behaviors, and bone mineral density in women runners. Snead, D.B., Stubbs, C.C., Weltman, J.Y., Evans, W.S., Veldhuis, J.D., Rogol, A.D., Teates, C.D., Weltman, A. Am. J. Clin. Nutr. (1992) [Pubmed]
  6. Insulin-dependent diabetes mellitus and menstrual dysfunction. Griffin, M.L., South, S.A., Yankov, V.I., Booth, R.A., Asplin, C.M., Veldhuis, J.D., Evans, W.S. Ann. Med. (1994) [Pubmed]
  7. Construction of human embryonic cDNA libraries: HD, PKD1 and BRCA1 are transcribed widely during embryogenesis. Buraczynska, M.J., Van Keuren, M.L., Buraczynska, K.M., Chang, Y.S., Crombez, E., Kurnit, D.M. Cytogenet. Cell Genet. (1995) [Pubmed]
  8. Local destabilisation of a DNA double helix by a T--T wobble pair. Cornelis, A.G., Haasnoot, J.H., den Hartog, J.F., de Rooij, M., van Boom, J.H., Cornelis, A. Nature (1979) [Pubmed]
  9. Individual tumors of multifocal EB virus-induced malignant lymphomas in tamarins arise from different B-cell clones. Cleary, M.L., Epstein, M.A., Finerty, S., Dorfman, R.F., Bornkamm, G.W., Kirkwood, J.K., Morgan, A.J., Sklar, J. Science (1985) [Pubmed]
  10. Formation of an adenine-thymine photoadduct in the deoxydinucleoside monophosphate d(TpA) and in DNA. Bose, S.N., Davies, R.J., Sethi, S.K., McCloskey, J.A. Science (1983) [Pubmed]
  11. An 'oligarchy' rules neural development. Rowitch, D.H., Lu, Q.R., Kessaris, N., Richardson, W.D. Trends Neurosci. (2002) [Pubmed]
  12. Expression microarray analysis and oligo array comparative genomic hybridization of acquired gemcitabine resistance in mouse colon reveals selection for chromosomal aberrations. van de Wiel, M.A., Costa, J.L., Smid, K., Oudejans, C.B., Bergman, A.M., Meijer, G.A., Peters, G.J., Ylstra, B. Cancer Res. (2005) [Pubmed]
  13. Biological basis for the clinical use of interferon. Dianzani, F. Gut (1993) [Pubmed]
  14. Plasma testosterone profiles in Cushing's syndrome. Smals, A.G., Kloppenborg, P.W., Benraad, T.J. J. Clin. Endocrinol. Metab. (1977) [Pubmed]
  15. Levonorgestrel implants (Norplant II) for male contraception clinical trials: combination with transdermal and injectable testosterone. Gonzalo, I.T., Swerdloff, R.S., Nelson, A.L., Clevenger, B., Garcia, R., Berman, N., Wang, C. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  16. The effect of fructan on membrane lipid organization and dynamics in the dry state. Vereyken, I.J., Chupin, V., Hoekstra, F.A., Smeekens, S.C., de Kruijff, B. Biophys. J. (2003) [Pubmed]
  17. Shared oligodendrocyte lineage gene expression in gliomas and oligodendrocyte progenitor cells. Bouvier, C., Bartoli, C., Aguirre-Cruz, L., Virard, I., Colin, C., Fernandez, C., Gouvernet, J., Figarella-Branger, D. J. Neurosurg. (2003) [Pubmed]
  18. An oligodendrocyte-specific zinc-finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation. Wang, S.Z., Dulin, J., Wu, H., Hurlock, E., Lee, S.E., Jansson, K., Lu, Q.R. Development (2006) [Pubmed]
  19. Translation and stability of human globin mRNA in Xenopus oocytes. Maniatis, G.M., Ramirez, F., Cann, A., Marks, P.A., Bank, A. J. Clin. Invest. (1976) [Pubmed]
  20. Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium Alcanivorax borkumensis. Schneiker, S., Martins dos Santos, V.A., Bartels, D., Bekel, T., Brecht, M., Buhrmester, J., Chernikova, T.N., Denaro, R., Ferrer, M., Gertler, C., Goesmann, A., Golyshina, O.V., Kaminski, F., Khachane, A.N., Lang, S., Linke, B., McHardy, A.C., Meyer, F., Nechitaylo, T., Pühler, A., Regenhardt, D., Rupp, O., Sabirova, J.S., Selbitschka, W., Yakimov, M.M., Timmis, K.N., Vorhölter, F.J., Weidner, S., Kaiser, O., Golyshin, P.N. Nat. Biotechnol. (2006) [Pubmed]
  21. Structure-activity relationships of oligo-beta-glucoside elicitors of phytoalexin accumulation in soybean. Cheong, J.J., Birberg, W., Fügedi, P., Pilotti, A., Garegg, P.J., Hong, N., Ogawa, T., Hahn, M.G. Plant Cell (1991) [Pubmed]
  22. Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation. Samanta, J., Kessler, J.A. Development (2004) [Pubmed]
  23. Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS. Jakovcevski, I., Zecevic, N. J. Neurosci. (2005) [Pubmed]
  24. Olig gene function in CNS development and disease. Ligon, K.L., Fancy, S.P., Franklin, R.J., Rowitch, D.H. Glia (2006) [Pubmed]
  25. Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. Lu, Q.R., Park, J.K., Noll, E., Chan, J.A., Alberta, J., Yuk, D., Alzamora, M.G., Louis, D.N., Stiles, C.D., Rowitch, D.H., Black, P.M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  26. Amifostine inhibits hematopoietic progenitor cell apoptosis by activating NF-kappaB/Rel transcription factors. Romano, M.F., Lamberti, A., Bisogni, R., Garbi, C., Pagnano, A.M., Auletta, P., Tassone, P., Turco, M.C., Venuta, S. Blood (1999) [Pubmed]
  27. In vivo biological response to recombinant interferon-gamma during a phase I dose-response trial in patients with metastatic melanoma. Kirkwood, J.M., Ernstoff, M.S., Trautman, T., Hebert, G., Nishida, Y., Davis, C.A., Balzer, J., Reich, S., Schindler, J., Rudnick, S.A. J. Clin. Oncol. (1990) [Pubmed]
  28. Inhibition of hepatitis B virus replication by targeted pretreatment of complexed antisense DNA in vitro. Nakazono, K., Ito, Y., Wu, C.H., Wu, G.Y. Hepatology (1996) [Pubmed]
  29. The occurrence of novel 9-O-sulfated N-glycolylneuraminic acid-capped alpha2-->5-Oglycolyl-linked oligo/polyNeu5Gc chains in sea urchin egg cell surface glycoprotein. Identification of a new chain termination signal for polysialyltransferase. Kitazume, S., Kitajima, K., Inoue, S., Haslam, S.M., Morris, H.R., Dell, A., Lennarz, W.J., Inoue, Y. J. Biol. Chem. (1996) [Pubmed]
  30. The in vitro DNA-binding properties of purified nuclear lamin proteins and vimentin. Shoeman, R.L., Traub, P. J. Biol. Chem. (1990) [Pubmed]
  31. Crystallization and preliminary X-ray analysis of human platelet profilin complexed with an oligo proline peptide. Mahoney, N.M., Almo, S.C. Acta Crystallogr. D Biol. Crystallogr. (1998) [Pubmed]
  32. GlyNest and CASPER: two independent approaches to estimate 1H and 13C NMR shifts of glycans available through a common web-interface. Loss, A., Stenutz, R., Schwarzer, E., von der Lieth, C.W. Nucleic Acids Res. (2006) [Pubmed]
  33. Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections: a useful method for the diagnosis of lymphoblastic lymphoma. Suzumiya, J., Ohshima, K., Kikuchi, M., Takeshita, M., Akamatsu, M., Tashiro, K. J. Pathol. (1997) [Pubmed]
  34. Hybrid oligonucleotides: synthesis, biophysical properties, stability studies, and biological activity. Yu, D., Iyer, R.P., Shaw, D.R., Lisziewicz, J., Li, Y., Jiang, Z., Roskey, A., Agrawal, S. Bioorg. Med. Chem. (1996) [Pubmed]
  35. The urokinase receptor (CD87) facilitates CD11b/CD18-mediated adhesion of human monocytes. Sitrin, R.G., Todd, R.F., Albrecht, E., Gyetko, M.R. J. Clin. Invest. (1996) [Pubmed]
  36. Arsenic trioxide induces apoptosis in human gastric cancer cells through up-regulation of p53 and activation of caspase-3. Jiang, X.H., Wong, B.C., Yuen, S.T., Jiang, S.H., Cho, C.H., Lai, K.C., Lin, M.C., Kung, H.F., Lam, S.K., Chun-Yu Wong, B. Int. J. Cancer (2001) [Pubmed]
  37. The 5' splice site consensus RNA oligonucleotide induces assembly of U2/U4/U5/U6 small nuclear ribonucleoprotein complexes. Hall, K.B., Konarska, M.M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  38. Characterization of the oligodeoxynucleotide-mediated inhibition of interferon-gamma-induced major histocompatibility complex class I and intercellular adhesion molecule-1. Ramanathan, M., Lantz, M., MacGregor, R.D., Garovoy, M.R., Hunt, C.A. J. Biol. Chem. (1994) [Pubmed]
  39. High throughput immuno-screening of cDNA expression libraries produced by in vitro recombination; exploring the Plasmodium falciparum proteome. Sowa, M.P., Sharling, L., Humphreys, G., Cavanagh, D.R., Gregory, W.F., Fenn, K., Creasey, A.M., Arnot, D.E. Mol. Biochem. Parasitol. (2004) [Pubmed]
  40. Mesenchymal stem cells instruct oligodendrogenic fate decision on adult neural stem cells. Rivera, F.J., Couillard-Despres, S., Pedre, X., Ploetz, S., Caioni, M., Lois, C., Bogdahn, U., Aigner, L. Stem Cells (2006) [Pubmed]
  41. E2F-1 overexpression in U2OS cells increases cyclin B1 levels and cdc2 kinase activity and sensitizes cells to antimitotic agents. Russo, A.J., Magro, P.G., Hu, Z., Li, W.W., Peters, R., Mandola, J., Banerjee, D., Bertino, J.R. Cancer Res. (2006) [Pubmed]
  42. Effect of C-terminal deletion of P53 on heat induced CD95 expression and apoptosis in a rat histiocytoma. Sreedhar, A.S., Pardhasaradhi, B.V., Khar, A., Srinivas, U.K. Oncogene (2002) [Pubmed]
  43. Gastrin and gastrin receptor activation: an early event in the adenoma-carcinoma sequence. Smith, A.M., Watson, S.A. Gut (2000) [Pubmed]
  44. Oligodendrogliomas: an update on basic and clinical research. Sanson, M., Aguirre-Cruz, L., Cartalat-Carel, S., Hoang-Xuan, K. Current neurology and neuroscience reports. (2003) [Pubmed]
  45. Anti-human Olig2 antibody as a useful immunohistochemical marker of normal oligodendrocytes and gliomas. Yokoo, H., Nobusawa, S., Takebayashi, H., Ikenaka, K., Isoda, K., Kamiya, M., Sasaki, A., Hirato, J., Nakazato, Y. Am. J. Pathol. (2004) [Pubmed]
  46. The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. Ligon, K.L., Alberta, J.A., Kho, A.T., Weiss, J., Kwaan, M.R., Nutt, C.L., Louis, D.N., Stiles, C.D., Rowitch, D.H. J. Neuropathol. Exp. Neurol. (2004) [Pubmed]
  47. Expression of immune sensitization to epithelial cell-associated components in the cotton-top tamarin: a model of chronic ulcerative colitis. Winter, H.S., Crum, P.M., King, N.W., Sehgal, P.K., Roche, J.K. Gastroenterology (1989) [Pubmed]
 
WikiGenes - Universities