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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Tomik, B. et al.

Tomik, Adamek, Lechwacka, Orłowiejska-Gillert, Bała-Słodowska, Głodzik-Sobańska, Kusiak, Szczudlik,

ALS-Plus syndrome. A clinical and neuropathological case study.

ALS-Plus syndrome occurs rarely and usually presents typical ALS phenotype associated with dementia, Parkinsonism or both. We reported a case of sporadic, definite ALS with pseudobulbar palsy, emotional lability and selective cognitive deficit in the presence of frontal lobe dementia. Neuropsychological tests predominantly demonstrated perserveration and dynamic apraxia, CT and MRI scans showed widened subarachnoideal spaces in the frontal and temporal regions. The neuropathological findings confirmed ALS processes i.e. atrophy of motor nuclei in brainstem and anterior horns of cervical spinal cord and showed mild atrophy and status spongiosus in the frontal lobes. These findings suggest the co-occurrence of sporadic ALS and frontal lobe dementia: ALS-Plus syndrome.[1]

References

ALS-Plus syndrome. A clinical and neuropathological case study. Tomik, B., Adamek, D., Lechwacka, A., Orłowiejska-Gillert, M., Bała-Słodowska, M., Głodzik-Sobańska, L., Kusiak, M., Szczudlik, A. Polish journal of pathology : official journal of the Polish Society of Pathologists. (2000) [Pubmed]

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