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MeSH Review

Parkinsonian Disorders

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Disease relevance of Parkinsonian Disorders


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Chemical compound and disease context of Parkinsonian Disorders


Biological context of Parkinsonian Disorders


Anatomical context of Parkinsonian Disorders


Gene context of Parkinsonian Disorders


Analytical, diagnostic and therapeutic context of Parkinsonian Disorders


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  2. A candidate gene for human neurodegenerative disorders: a rat PKC gamma mutation causes a Parkinsonian syndrome. Craig, N.J., Durán Alonso, M.B., Hawker, K.L., Shiels, P., Glencorse, T.A., Campbell, J.M., Bennett, N.K., Canham, M., Donald, D., Gardiner, M., Gilmore, D.P., MacDonald, R.J., Maitland, K., McCallion, A.S., Russell, D., Payne, A.P., Sutcliffe, R.G., Davies, R.W. Nat. Neurosci. (2001) [Pubmed]
  3. Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Ishihara, T., Hong, M., Zhang, B., Nakagawa, Y., Lee, M.K., Trojanowski, J.Q., Lee, V.M. Neuron (1999) [Pubmed]
  4. Idiopathic hemiparetic parkinsonism, a syndrome distinct from idiopathic parkinsonism. De Keyser, J., Herroelen, L., Vervaeck, M., Bruyland, M., Ebinger, G. Lancet (1992) [Pubmed]
  5. A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Burns, R.S., Chiueh, C.C., Markey, S.P., Ebert, M.H., Jacobowitz, D.M., Kopin, I.J. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  6. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Lewis, J., McGowan, E., Rockwood, J., Melrose, H., Nacharaju, P., Van Slegtenhorst, M., Gwinn-Hardy, K., Paul Murphy, M., Baker, M., Yu, X., Duff, K., Hardy, J., Corral, A., Lin, W.L., Yen, S.H., Dickson, D.W., Davies, P., Hutton, M. Nat. Genet. (2000) [Pubmed]
  7. Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease. Curtis, A.R., Fey, C., Morris, C.M., Bindoff, L.A., Ince, P.G., Chinnery, P.F., Coulthard, A., Jackson, M.J., Jackson, A.P., McHale, D.P., Hay, D., Barker, W.A., Markham, A.F., Bates, D., Curtis, A., Burn, J. Nat. Genet. (2001) [Pubmed]
  8. High levels of a retinoic acid-generating dehydrogenase in the meso-telencephalic dopamine system. McCaffery, P., Dräger, U.C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  9. Damage to dopamine systems differs between Parkinson's disease and Alzheimer's disease with parkinsonism. Murray, A.M., Weihmueller, F.B., Marshall, J.F., Hurtig, H.I., Gottleib, G.L., Joyce, J.N. Ann. Neurol. (1995) [Pubmed]
  10. Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations. Kumru, H., Santamaria, J., Tolosa, E., Valldeoriola, F., Muñoz, E., Marti, M.J., Iranzo, A. Ann. Neurol. (2004) [Pubmed]
  11. Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Widner, H., Tetrud, J., Rehncrona, S., Snow, B., Brundin, P., Gustavii, B., Björklund, A., Lindvall, O., Langston, J.W. N. Engl. J. Med. (1992) [Pubmed]
  12. The clinical syndrome of striatal dopamine deficiency. Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Burns, R.S., LeWitt, P.A., Ebert, M.H., Pakkenberg, H., Kopin, I.J. N. Engl. J. Med. (1985) [Pubmed]
  13. Reversible parkinsonism related to meperidine. Lieberman, A.N., Goldstein, M. N. Engl. J. Med. (1985) [Pubmed]
  14. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., Shimizu, N. Nature (1998) [Pubmed]
  15. 1-methyl-4-phenylpyridine is neurotoxic to the nigrostriatal dopamine pathway. Bradbury, A.J., Costall, B., Domeney, A.M., Jenner, P., Kelly, M.E., Marsden, C.D., Naylor, R.J. Nature (1986) [Pubmed]
  16. Exacerbation of parkinsonism by methyldopa. Rosenblum, A.M., Montgomery, E.B. JAMA (1980) [Pubmed]
  17. When to use levodopa in parkinsonism. Rajput, A.H., Uitti, R.J. Lancet (1986) [Pubmed]
  18. Possible mechanism of action of deprenyl in parkinsonism. Paterson, I.A., Juorio, A.V., Boulton, A.A. Lancet (1990) [Pubmed]
  19. Transcranial brain sonography findings in discriminating between parkinsonism and idiopathic Parkinson disease. Walter, U., Dressler, D., Probst, T., Wolters, A., Abu-Mugheisib, M., Wittstock, M., Benecke, R. Arch. Neurol. (2007) [Pubmed]
  20. Homozygous deletions in parkin gene in European and North African families with autosomal recessive juvenile parkinsonism. The European Consortium on Genetic Susceptibility in Parkinson's Disease and the French Parkinson's Disease Genetics Study Group. Lücking, C.B., Abbas, N., Dürr, A., Bonifati, V., Bonnet, A.M., de Broucker, T., De Michele, G., Wood, N.W., Agid, Y., Brice, A. Lancet (1998) [Pubmed]
  21. Origin of the mutations in the parkin gene in Europe: exon rearrangements are independent recurrent events, whereas point mutations may result from Founder effects. Periquet, M., Lücking, C., Vaughan, J., Bonifati, V., Dürr, A., De Michele, G., Horstink, M., Farrer, M., Illarioshkin, S.N., Pollak, P., Borg, M., Brefel-Courbon, C., Denefle, P., Meco, G., Gasser, T., Breteler, M.M., Wood, N., Agid, Y., Brice, A. Am. J. Hum. Genet. (2001) [Pubmed]
  22. A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease. Abbas, N., Lücking, C.B., Ricard, S., Dürr, A., Bonifati, V., De Michele, G., Bouley, S., Vaughan, J.R., Gasser, T., Marconi, R., Broussolle, E., Brefel-Courbon, C., Harhangi, B.S., Oostra, B.A., Fabrizio, E., Böhme, G.A., Pradier, L., Wood, N.W., Filla, A., Meco, G., Denefle, P., Agid, Y., Brice, A. Hum. Mol. Genet. (1999) [Pubmed]
  23. Parkin genetics: one model for Parkinson's disease. Mata, I.F., Lockhart, P.J., Farrer, M.J. Hum. Mol. Genet. (2004) [Pubmed]
  24. Dopamine covalently modifies and functionally inactivates parkin. LaVoie, M.J., Ostaszewski, B.L., Weihofen, A., Schlossmacher, M.G., Selkoe, D.J. Nat. Med. (2005) [Pubmed]
  25. Mitochondria and dopamine: new insights into recessive parkinsonism. Shen, J., Cookson, M.R. Neuron (2004) [Pubmed]
  26. Mutations in the Na+/K+ -ATPase alpha3 gene ATP1A3 are associated with rapid-onset dystonia parkinsonism. de Carvalho Aguiar, P., Sweadner, K.J., Penniston, J.T., Zaremba, J., Liu, L., Caton, M., Linazasoro, G., Borg, M., Tijssen, M.A., Bressman, S.B., Dobyns, W.B., Brashear, A., Ozelius, L.J. Neuron (2004) [Pubmed]
  27. Nitric oxide, glial cells and neuronal degeneration in parkinsonism. Hirsch, E.C., Hunot, S. Trends Pharmacol. Sci. (2000) [Pubmed]
  28. A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor. Farrer, M., Gwinn-Hardy, K., Muenter, M., DeVrieze, F.W., Crook, R., Perez-Tur, J., Lincoln, S., Maraganore, D., Adler, C., Newman, S., MacElwee, K., McCarthy, P., Miller, C., Waters, C., Hardy, J. Hum. Mol. Genet. (1999) [Pubmed]
  29. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Zimprich, A., Biskup, S., Leitner, P., Lichtner, P., Farrer, M., Lincoln, S., Kachergus, J., Hulihan, M., Uitti, R.J., Calne, D.B., Stoessl, A.J., Pfeiffer, R.F., Patenge, N., Carbajal, I.C., Vieregge, P., Asmus, F., Müller-Myhsok, B., Dickson, D.W., Meitinger, T., Strom, T.M., Wszolek, Z.K., Gasser, T. Neuron (2004) [Pubmed]
  30. Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36. van Duijn, C.M., Dekker, M.C., Bonifati, V., Galjaard, R.J., Houwing-Duistermaat, J.J., Snijders, P.J., Testers, L., Breedveld, G.J., Horstink, M., Sandkuijl, L.A., van Swieten, J.C., Oostra, B.A., Heutink, P. Am. J. Hum. Genet. (2001) [Pubmed]
  31. Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability. Beilina, A., Van Der Brug, M., Ahmad, R., Kesavapany, S., Miller, D.W., Petsko, G.A., Cookson, M.R. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  32. Stress-induced neurological impairments in an animal model of parkinsonism. Snyder, A.M., Stricker, E.M., Zigmond, M.J. Ann. Neurol. (1985) [Pubmed]
  33. Dopa-responsive parkinsonism with normal 6[18F]-fluorodopa positron emission tomography scans. Lang, A.E., Garnett, E.S. Ann. Neurol. (1990) [Pubmed]
  34. FDG PET in the differential diagnosis of parkinsonian disorders. Eckert, T., Barnes, A., Dhawan, V., Frucht, S., Gordon, M.F., Feigin, A.S., Eidelberg, D. Neuroimage (2005) [Pubmed]
  35. Reversal of akinesia in experimental parkinsonism by GABA antagonist microinjections in the pedunculopontine nucleus. Nandi, D., Aziz, T.Z., Giladi, N., Winter, J., Stein, J.F. Brain (2002) [Pubmed]
  36. Association between cardiac denervation and parkinsonism caused by alpha-synuclein gene triplication. Singleton, A., Gwinn-Hardy, K., Sharabi, Y., Li, S.T., Holmes, C., Dendi, R., Hardy, J., Singleton, A., Crawley, A., Goldstein, D.S. Brain (2004) [Pubmed]
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