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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

A retro-inverso Prosaptide D5 promotes a myelination process in developing rats.

The myelinotrophic action of Prosaptide D5 was investigated in developing rats. Sulfatide concentrations in brain and sciatic nerve were determined to assess the development of myelination. Subcutaneous D5-injection significantly increased sulfatide concentrations in both brain and sciatic nerve by 250 and 150% over controls, respectively. D5 promoted ERK phosphorylation in iSC Schwann cells similar to prosaposin. The results showed that D5 treatment stimulated a myelination process in developing rat.[1]

References

  1. A retro-inverso Prosaptide D5 promotes a myelination process in developing rats. Hiraiwa, M., Campana, W.M., Wang, C.Y., Otero, D.A., O'Brien, J.S. Brain Res. Dev. Brain Res. (2001) [Pubmed]
 
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