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Chemical Compound Review

CHEBI:60361     (2R,3S,4S,5R,6R)-3,5- dihydroxy-2...

Synonyms: HMDB00024, AC1O52SD, 151122-71-3, Sulfatide (d18:1/24:0), tetracosanoyl sulfatide, ...
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Disease relevance of sulfatide


Psychiatry related information on sulfatide


High impact information on sulfatide


Chemical compound and disease context of sulfatide


Biological context of sulfatide


Anatomical context of sulfatide


Associations of sulfatide with other chemical compounds


Gene context of sulfatide

  • Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells [27].
  • The myelin-associated lipids galactocerebroside and sulfatide were modestly reduced in Igf1(-/-) brains [28].
  • We identified the endogenous CD1 ligands sulfatide and monosialoganglioside GM1 as MRP1 substrates, but exogenous addition of these substrates could not restore the defects caused by blocking MRP1 activity during DC differentiation [29].
  • The binding was inhibited by an excess of unlabeled TSP and by heparin, suggesting that the receptor could be a heparan-sulfate proteoglycan or a sulfatide [30].
  • These observations led to the hypothesis that sulfatide may play a role in facilitating the disengagement of CD62, allowing the efficient exit of granulocytes from the blood stream at sites of inflammation [31].

Analytical, diagnostic and therapeutic context of sulfatide


  1. Lipid microarrays identify key mediators of autoimmune brain inflammation. Kanter, J.L., Narayana, S., Ho, P.P., Catz, I., Warren, K.G., Sobel, R.A., Steinman, L., Robinson, W.H. Nat. Med. (2006) [Pubmed]
  2. Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. Zajonc, D.M., Maricic, I., Wu, D., Halder, R., Roy, K., Wong, C.H., Kumar, V., Wilson, I.A. J. Exp. Med. (2005) [Pubmed]
  3. Glycolipids in human lung carcinoma of histologically different types. Yoda, Y., Gasa, S., Makita, A., Fujioka, Y., Kikuchi, Y., Hashimoto, M. J. Natl. Cancer Inst. (1979) [Pubmed]
  4. A turn of the sulfatide in Alzheimer's disease. Irizarry, M.C. Ann. Neurol. (2003) [Pubmed]
  5. Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia. Han, X., Fagan, A.M., Cheng, H., Morris, J.C., Xiong, C., Holtzman, D.M. Ann. Neurol. (2003) [Pubmed]
  6. Mass spectrometric analysis reveals changes in phospholipid, neutral sphingolipid and sulfatide molecular species in progressive epilepsy with mental retardation, EPMR, brain: a case study. Hermansson, M., Käkelä, R., Berghäll, M., Lehesjoki, A.E., Somerharju, P., Lahtinen, U. J. Neurochem. (2005) [Pubmed]
  7. CSF sulfatide distinguishes between normal pressure hydrocephalus and subcortical arteriosclerotic encephalopathy. Tullberg, M., Månsson, J.E., Fredman, P., Lekman, A., Blennow, K., Ekman, R., Rosengren, L.E., Tisell, M., Wikkelsø, C. J. Neurol. Neurosurg. Psychiatr. (2000) [Pubmed]
  8. Differences in cerebrospinal fluid dynamics do not affect the levels of biochemical markers in ventricular CSF from patients with aqueductal stenosis and idiopathic normal pressure hydrocephalus. Tisell, M., Tullberg, M., Månsson, J.E., Fredman, P., Blennow, K., Wikkelsø, C. Eur. J. Neurol. (2004) [Pubmed]
  9. Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability. Coetzee, T., Fujita, N., Dupree, J., Shi, R., Blight, A., Suzuki, K., Suzuki, K., Popko, B. Cell (1996) [Pubmed]
  10. Prevention of autoimmunity by targeting a distinct, noninvariant CD1d-reactive T cell population reactive to sulfatide. Jahng, A., Maricic, I., Aguilera, C., Cardell, S., Halder, R.C., Kumar, V. J. Exp. Med. (2004) [Pubmed]
  11. Heparin- and sulfatide-binding peptides from the type I repeats of human thrombospondin promote melanoma cell adhesion. Guo, N.H., Krutzsch, H.C., Nègre, E., Vogel, T., Blake, D.A., Roberts, D.D. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  12. Suramin inhibits laminin- and thrombospondin-mediated melanoma cell adhesion and migration and binding of these adhesive proteins to sulfatide. Zabrenetzky, V.S., Kohn, E.C., Roberts, D.D. Cancer Res. (1990) [Pubmed]
  13. Purification and characterization of a novel ceramidase from Pseudomonas aeruginosa. Okino, N., Tani, M., Imayama, S., Ito, M. J. Biol. Chem. (1998) [Pubmed]
  14. Regional differences in rat brain lipids during global ischemia. Chavko, M., Nemoto, E.M. Stroke (1992) [Pubmed]
  15. Lysine residue 117 of the FasG adhesin of enterotoxigenic Escherichia coli is essential for binding of 987P fimbriae to sulfatide. Choi, B.K., Schifferli, D.M. Infect. Immun. (1999) [Pubmed]
  16. The L2/HNK-1 carbohydrate of neural cell adhesion molecules is involved in cell interactions. Künemund, V., Jungalwala, F.B., Fischer, G., Chou, D.K., Keilhauer, G., Schachner, M. J. Cell Biol. (1988) [Pubmed]
  17. Characterization of a mutation in a family with saposin B deficiency: a glycosylation site defect. Kretz, K.A., Carson, G.S., Morimoto, S., Kishimoto, Y., Fluharty, A.L., O'Brien, J.S. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  18. Compound heterozygosity for metachromatic leukodystrophy and arylsulfatase A pseudodeficiency alleles is not associated with progressive neurological disease. Penzien, J.M., Kappler, J., Herschkowitz, N., Schuknecht, B., Leinekugel, P., Propping, P., Tønnesen, T., Lou, H., Moser, H., Zierz, S. Am. J. Hum. Genet. (1993) [Pubmed]
  19. Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides. Hiraiwa, M., Taylor, E.M., Campana, W.M., Darin, S.J., O'Brien, J.S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  20. 04 and A007-sulfatide antibodies bind to embryonic Schwann cells prior to the appearance of galactocerebroside; regulation of the antigen by axon-Schwann cell signals and cyclic AMP. Mirsky, R., Dubois, C., Morgan, L., Jessen, K.R. Development (1990) [Pubmed]
  21. Myelin-specific proteins and glycolipids in rat Schwann cells and oligodendrocytes in culture. Mirsky, R., Winter, J., Abney, E.R., Pruss, R.M., Gavrilovic, J., Raff, M.C. J. Cell Biol. (1980) [Pubmed]
  22. Malaria sporozoites and circumsporozoite proteins bind specifically to sulfated glycoconjugates. Pancake, S.J., Holt, G.D., Mellouk, S., Hoffman, S.L. J. Cell Biol. (1992) [Pubmed]
  23. Targeted disruption of the mouse sphingolipid activator protein gene: a complex phenotype, including severe leukodystrophy and wide-spread storage of multiple sphingolipids. Fujita, N., Suzuki, K., Vanier, M.T., Popko, B., Maeda, N., Klein, A., Henseler, M., Sandhoff, K., Nakayasu, H., Suzuki, K. Hum. Mol. Genet. (1996) [Pubmed]
  24. Synthesis of myelin glycosphingolipids (galactosylceramide and galactosyl(3-O-sulfate)ceramide (sulfatide)) by cloned cell lines derived from mouse neurotumors. Dawson, G., Sundarraj, N., Pfeiffer, S.E. J. Biol. Chem. (1977) [Pubmed]
  25. C16:0 Sulfatide Inhibits Insulin Secretion in Rat {beta}-Cells by Reducing the Sensitivity of KATP Channels to ATP Inhibition. Buschard, K., Blomqvist, M., M??nsson, J.E., Fredman, P., Juhl, K., Gromada, J. Diabetes (2006) [Pubmed]
  26. Sulfatide controls insulin secretion by modulation of ATP-sensitive K(+)-channel activity and Ca(2+)-dependent exocytosis in rat pancreatic beta-cells. Buschard, K., Høy, M., Bokvist, K., Olsen, H.L., Madsbad, S., Fredman, P., Gromada, J. Diabetes (2002) [Pubmed]
  27. Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells. Campana, W.M., Hiraiwa, M., O'Brien, J.S. FASEB J. (1998) [Pubmed]
  28. Biochemical and morphometric analyses show that myelination in the insulin-like growth factor 1 null brain is proportionate to its neuronal composition. Cheng, C.M., Joncas, G., Reinhardt, R.R., Farrer, R., Quarles, R., Janssen, J., McDonald, M.P., Crawley, J.N., Powell-Braxton, L., Bondy, C.A. J. Neurosci. (1998) [Pubmed]
  29. Dendritic Cells Require Multidrug Resistance Protein 1 (ABCC1) Transporter Activity for Differentiation. van de Ven, R., de Jong, M.C., Reurs, A.W., Schoonderwoerd, A.J., Jansen, G., Hooijberg, J.H., Scheffer, G.L., de Gruijl, T.D., Scheper, R.J. J. Immunol. (2006) [Pubmed]
  30. Involvement of thrombospondin in the adherence of human breast-adenocarcinoma cells: a possible role in the metastatic process. Incardona, F., Calvo, F., Fauvel-Lafeve, F., Legrand, Y., Legrand, C. Int. J. Cancer (1993) [Pubmed]
  31. CD62/P-selectin binding sites for myeloid cells and sulfatides are overlapping. Bajorath, J., Hollenbaugh, D., King, G., Harte, W., Eustice, D.C., Darveau, R.P., Aruffo, A. Biochemistry (1994) [Pubmed]
  32. Paranodal junction formation and spermatogenesis require sulfoglycolipids. Honke, K., Hirahara, Y., Dupree, J., Suzuki, K., Popko, B., Fukushima, K., Fukushima, J., Nagasawa, T., Yoshida, N., Wada, Y., Taniguchi, N. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  33. Hepatocyte plasma membrane glycosphingolipid reactive with sera from patients with autoimmune chronic active hepatitis: its identification as sulfatide. Toda, G., Ikeda, Y., Kashiwagi, M., Iwamori, M., Oka, H. Hepatology (1990) [Pubmed]
  34. Mono-sulfated globopentaosylceramide from human kidney. Nagai, K., Roberts, D.D., Toida, T., Matsumoto, H., Kushi, Y., Handa, S., Ishizuka, I. J. Biol. Chem. (1989) [Pubmed]
  35. Sulfatide-binding domain of the laminin A chain. Taraboletti, G., Rao, C.N., Krutzsch, H.C., Liotta, L.A., Roberts, D.D. J. Biol. Chem. (1990) [Pubmed]
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