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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Markedly reduced chronic nociceptive response in mice lacking the PAC1 receptor.

The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has been proposed to have a role in nociception. Here we have used the formalin test, thermal laser stimulation and mechanical von Frey stimulation to investigate possible alteration of PAC1-/- mice nociceptive behaviour. Our finding, that PAC1-/- mice have a substantial, 75% decrease in nociceptive response during the late phase, provides clear evidence that the specific PACAP-receptor PAC1 is involved in the mediation of nociceptive responses during chronic conditions such as inflammation. PAC1-/- mice had small or no changes in the response to mechanical and thermal laser stimulation. This suggests a limited, if any, involvement of PAC1 in nociception after short-lasting stimuli. Injury-induced changes in DRG neuropeptide expression were more pronounced in PAC1-/- mice, implying neuroregulatory functions of PAC1.[1]


  1. Markedly reduced chronic nociceptive response in mice lacking the PAC1 receptor. Jongsma, H., Pettersson, L.M., Zhang Yz, n.u.l.l., Reimer, M.K., Kanje, M., Waldenström, A., Sundler, F., Danielsen, N. Neuroreport (2001) [Pubmed]
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