Gene Review:
Adcyap1 - adenylate cyclase activating polypeptide 1
Mus musculus
Synonyms:
PACAP, Pacap, Pituitary adenylate cyclase-activating polypeptide
Persson-Sjögren,
Forsgren,
Lindström,
Harmar,
Marston,
Shen,
Spratt,
West,
Sheward,
Morrison,
Dorin,
Piggins,
Reubi,
Kelly,
Maywood,
Hastings,
Sheward,
Lutz,
Copp,
Harmar,
Fowkes,
Sidhu,
Sosabowski,
King,
Burrin,
Colwell,
Michel,
Itri,
Rodriguez,
Tam,
Lelièvre,
Hu,
Waschek,
Delgado,
Freson,
Hashimoto,
Thys,
Wittevrongel,
Danloy,
Morita,
Shintani,
Tomiyama,
Vermylen,
Hoylaerts,
Baba,
Van Geet,
Taylor,
Mizushima,
Nakamura,
Matsumoto,
Dohi,
Matsumoto,
Shioda,
Banks,
- Anti-inflammatory role in septic shock of pituitary adenylate cyclase-activating polypeptide receptor. Martinez, C., Abad, C., Delgado, M., Arranz, A., Juarranz, M.G., Rodriguez-Henche, N., Brabet, P., Leceta, J., Gomariz, R.P. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Pituitary adenylate cyclase-activating polypeptide-induced differentiation of embryonic neural stem cells into astrocytes is mediated via the beta isoform of protein kinase C. Watanabe, J., Ohba, M., Ohno, F., Kikuyama, S., Nakamura, M., Nakaya, K., Arimura, A., Shioda, S., Nakajo, S. J. Neurosci. Res. (2006)
- Vasoactive intestinal polypeptide and pituitary adenylate cyclase activating polypeptide: Effects on insulin release in isolated mouse islets in relation to metabolic status and age. Persson-Sjögren, S., Forsgren, S., Lindström, P. Neuropeptides (2006)
- Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6. Ohtaki, H., Nakamachi, T., Dohi, K., Aizawa, Y., Takaki, A., Hodoyama, K., Yofu, S., Hashimoto, H., Shintani, N., Baba, A., Kopf, M., Iwakura, Y., Matsuda, K., Arimura, A., Shioda, S. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis. Hamelink, C., Tjurmina, O., Damadzic, R., Young, W.S., Weihe, E., Lee, H.W., Eiden, L.E. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice. Tanaka, K., Shintani, N., Hashimoto, H., Kawagishi, N., Ago, Y., Matsuda, T., Hashimoto, R., Kunugi, H., Yamamoto, A., Kawaguchi, C., Shimada, T., Baba, A. J. Neurosci. (2006)
- PACAP deficient mice display reduced carbohydrate intake and PACAP activates NPY-containing neurons in the rat hypothalamic arcuate nucleus. Nakata, M., Kohno, D., Shintani, N., Nemoto, Y., Hashimoto, H., Baba, A., Yada, T. Neurosci. Lett. (2004)
- Defects in reproductive functions in PACAP-deficient female mice. Shintani, N., Mori, W., Hashimoto, H., Imai, M., Tanaka, K., Tomimoto, S., Hirose, M., Kawaguchi, C., Baba, A. Regul. Pept. (2002)
- Selective deficits in the circadian light response in mice lacking PACAP. Colwell, C.S., Michel, S., Itri, J., Rodriguez, W., Tam, J., Lelièvre, V., Hu, Z., Waschek, J.A. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004)
- Altered social behavior in pituitary adenylate cyclase-activating polypeptide type I receptor-deficient mice. Nicot, A., Otto, T., Brabet, P., Dicicco-Bloom, E.M. J. Neurosci. (2004)
- The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei. Harmar, A.J., Marston, H.M., Shen, S., Spratt, C., West, K.M., Sheward, W.J., Morrison, C.F., Dorin, J.R., Piggins, H.D., Reubi, J.C., Kelly, J.S., Maywood, E.S., Hastings, M.H. Cell (2002)
- The pituitary adenylate cyclase-activating polypeptide is a physiological inhibitor of platelet activation. Freson, K., Hashimoto, H., Thys, C., Wittevrongel, C., Danloy, S., Morita, Y., Shintani, N., Tomiyama, Y., Vermylen, J., Hoylaerts, M.F., Baba, A., Van Geet, C. J. Clin. Invest. (2004)
- PAC1 receptor-deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance. Jamen, F., Persson, K., Bertrand, G., Rodriguez-Henche, N., Puech, R., Bockaert, J., Ahrén, B., Brabet, P. J. Clin. Invest. (2000)
- Peptidergic activation of transcription and secretion in chromaffin cells. Cis and trans signaling determinants of pituitary adenylyl cyclase-activating polypeptide (PACAP). Taupenot, L., Mahata, S.K., Wu, H., O'Connor, D.T. J. Clin. Invest. (1998)
- Endogenous PACAP acts as a stress response peptide to protect cerebellar neurons from ethanol or oxidative insult. Vaudry, D., Hamelink, C., Damadzic, R., Eskay, R.L., Gonzalez, B., Eiden, L.E. Peptides (2005)
- The effect of cardiac arrest on the blood-testis barrier to albumin, tumor necrosis factor-alpha, pituitary adenylate cyclase activating polypeptide, sucrose, and verapamil in the mouse. Mizushima, H., Nakamura, Y., Matsumoto, H., Dohi, K., Matsumoto, K., Shioda, S., Banks, W.A. J. Androl. (2001)
- PACAP-type IB receptors mediate stimulation of phosphoinositide metabolism in mouse neuroblastoma cells, clone N1E-115. Taylor, J.E. Ann. N. Y. Acad. Sci. (1996)
- VIP and PACAP induce selective neuronal differentiation of mouse embryonic stem cells. Cazillis, M., Gonzalez, B.J., Billardon, C., Lombet, A., Fraichard, A., Samarut, J., Gressens, P., Vaudry, H., Rostène, W. Eur. J. Neurosci. (2004)
- Cloning and characterization of the mouse pituitary adenylate cyclase-activating polypeptide (PACAP) gene. Yamamoto, K., Hashimoto, H., Hagihara, N., Nishino, A., Fujita, T., Matsuda, T., Baba, A. Gene (1998)
- Expression of PACAP, and PACAP type 1 (PAC1) receptor mRNA during development of the mouse embryo. Sheward, W.J., Lutz, E.M., Copp, A.J., Harmar, A.J. Brain Res. Dev. Brain Res. (1998)
- Absence of pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein alpha-subunit gene in LbetaT2 gonadotrophs reveals disrupted cAMP-mediated gene transcription. Fowkes, R.C., Sidhu, K.K., Sosabowski, J.K., King, P., Burrin, J.M. J. Mol. Endocrinol. (2003)
- Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit CBP-NF-kappaB interaction in activated microglia. Delgado, M. Biochem. Biophys. Res. Commun. (2002)
- The effects of pituitary adenylate cyclase-activating polypeptide on acute and chronic morphine actions in mice. Mácsai, M., Pataki, I., Tóth, G., Szabó, G. Regul. Pept. (2002)
- Pituitary adenylate cyclase activating polypeptide-mediated intracrine signaling in the testicular germ cells. Li, M., Funahashi, H., Mbikay, M., Shioda, S., Arimura, A. Endocrine (2004)
- Receptors and transcriptional factors involved in the anti-inflammatory activity of VIP and PACAP. Leceta, J., Gomariz, R.P., Martinez, C., Abad, C., Ganea, D., Delgado, M. Ann. N. Y. Acad. Sci. (2000)
- Vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide inhibit the MEKK1/MEK4/JNK signaling pathway in LPS-stimulated macrophages. Delgado, M., Ganea, D. J. Neuroimmunol. (2000)
- Modulation of NMDA receptors by pituitary adenylate cyclase activating peptide in CA1 neurons requires G alpha q, protein kinase C, and activation of Src. Macdonald, D.S., Weerapura, M., Beazely, M.A., Martin, L., Czerwinski, W., Roder, J.C., Orser, B.A., MacDonald, J.F. J. Neurosci. (2005)
- The neuropeptide PACAP contributes to the glucagon response to insulin-induced hypoglycaemia in mice. Persson, K., Ahrén, B. Acta Physiol. Scand. (2002)
- Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit tumor necrosis factor alpha transcriptional activation by regulating nuclear factor-kB and cAMP response element-binding protein/c-Jun. Delgado, M., Munoz-Elias, E.J., Kan, Y., Gozes, I., Fridkin, M., Brenneman, D.E., Gomariz, R.P., Ganea, D. J. Biol. Chem. (1998)
- Overexpression of pituitary adenylate cyclase-activating polypeptide in islets inhibits hyperinsulinemia and islet hyperplasia in agouti yellow mice. Tomimoto, S., Hashimoto, H., Shintani, N., Yamamoto, K., Kawabata, Y., Hamagami, K., Yamagata, K., Miyagawa, J., Baba, A. J. Pharmacol. Exp. Ther. (2004)
- Pituitary adenylate cyclase-activating polypeptide induces cAMP production independently from vasoactive intestinal polypeptide in osteoblast-like cells. Suzuki, A., Kotoyori, J., Oiso, Y., Kozawa, O. Cell. Signal. (1994)
- Pituitary adenylate cyclase-activating polypeptide transduces through cAMP/PKA and PKC pathways and stimulates proopiomelanocortin gene transcription in mouse melanotropes. René, F., Monnier, D., Gaiddon, C., Félix, J.M., Loeffler, J.P. Neuroendocrinology (1996)