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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Reciprocation of renin dependency with sodium volume dependency in renal hypertension.

An angiotensin II inhibitor was administered to rats with two-kidney Goldblatt hypertension. The inhibitor produced a marked drop in blood pressure after 5 weeks but no significant change after 15 weeks of hypertension. However, even after 15 weeks of hypertension, following sodium depletion by either diuretics or a low sodium diet, the animals again became renin dependent as readministration of the inhibitor induced a significant fall in blood pressure. The data indicate that two-kidney Goldblatt hypertension is initially renin dependent but subsequently becomes sodium volume dependent in a way similar, although more protracted, to that already described for one-kidney Goldblatt hypertension.[1]


  1. Reciprocation of renin dependency with sodium volume dependency in renal hypertension. Gavras, H., Brunner, H.R., Thurston, H., Laragh, J.H. Science (1975) [Pubmed]
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