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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Effects of estrogen and neurotransmitters on the primary cultures of tilapia brain from different ages.

The effects of estrogen and neurotransmitters on the proliferation of brain cells were investigated in the primary cultures of tilapia brain from different ages. Treatment of brain cells that were cultured on day 1, 3, 5, 7, 10, 30, and 180 posthatching with serotonin (5-HT), resulted in a significant increase of the Brdu(+)-cell number. By contrast, norepinephrine (NE) resulted in a significant decrease and gamma-aminobutyric acid (GABA) had no effect. 17 beta-Estradiol (E(2)) significantly increased the Brdu(+)-cell number when the brain cells were cultured after 5 days of age, but had no effect when cultured on day 1 or 3 of age. These results indicate that the proliferation of brain cell is enhanced by 5-HT at each stage. This effect is mimicked by E(2) when given after 5 days of age. Conversely, NE has an effect to depress the proliferation of brain cells. Whereas, GABA has no effect.[1]

References

  1. Effects of estrogen and neurotransmitters on the primary cultures of tilapia brain from different ages. Tsai, C.L., Wang, L.H., Lin, Y.H. Brain Res. Dev. Brain Res. (2001) [Pubmed]
 
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