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Kovacs, J.A. et al.

Kovacs, Vogel, Metcalf, Baseler, Stevens, Adelsberger, Lempicki, Hengel, Sereti, Lambert, Dewar, Davey, Walker, Falloon, Polis, Masur, Lane,

Interleukin-2 induced immune effects in human immunodeficiency virus-infected patients receiving intermittent interleukin-2 immunotherapy.

To characterize the immunological effects of intermittent IL-2 therapy, which leads to selective increases in CD4+ T lymphocytes in HIV-infected patients, 11 patients underwent extensive immunological evaluation. While IL-2 induced changes in both CD4+ and CD8+ cell number acutely, only CD4+ cells showed sustained increases following discontinuation of IL-2. Transient increases in expression of the activation markers CD38 and HLA-DR were seen on both CD4+ and CD8+ cells, but CD25 (a chain of the IL-2 receptor) increased exclusively on CD4+ cells. This increase in CD25 expression was sustained for months following discontinuation of IL-2, and was seen in naive as well as memory cells. IL-2 induced cell proliferation, but tachyphylaxis to these proliferative effects developed after 1 week despite continued IL-2 administration. It thus appears that sustained CD25 expression selectively on CD4+ cells is a critical component of the immunological response to IL-2, and that intermittent administration of IL-2 is necessary to overcome the tachyphylaxis to IL-2-induced proliferation.[1]

References

Interleukin-2 induced immune effects in human immunodeficiency virus-infected patients receiving intermittent interleukin-2 immunotherapy. Kovacs, J.A., Vogel, S., Metcalf, J.A., Baseler, M., Stevens, R., Adelsberger, J., Lempicki, R., Hengel, R.L., Sereti, I., Lambert, L., Dewar, R.L., Davey, R.T., Walker, R.E., Falloon, J., Polis, M.A., Masur, H., Lane, H.C. Eur. J. Immunol. (2001) [Pubmed]

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