Disease relevance of Immunity

• Pure human interleukin 2 (IL-2), produced by the T-cell lymphoma Jurkat, was injected in mice to study the serum half-life, toxicity, and in vivo immunological effects of IL-2 [1].
• This report details a prospective study of the immunological effects on peripheral blood mononuclear cells of sequentially administered recombinant (r) interferon (IFN) gamma and rIFN alpha in 28 patients with metastatic renal cell carcinoma [2].
• We have conducted a study in patients with early-stage cervical cancer to assess the safety and immunological effects of vaccination with TA-HPV, a live recombinant vaccinia virus expressing modified forms of the HPV-16 and -18 E6 and E7 proteins [3].
• Numerous additional clinical trials have established the beneficial antiviral and immunological effects of indinavir in both antiretroviral-naive and -experienced patients with HIV infection [4].
• Neuropeptide Y (NPY) increases survival in experimental septic shock, which might be mediated by cardiovascular and/or immunological effects [5].

High impact information on Immunity

• Pathological and immunological effects of ingesting L-tryptophan and 1,1'-ethylidenebis (L-tryptophan) in Lewis rats [6].
• Both the copper-chelating and immunological effects of penicillamine are probably important in improving survival [7].
• In common with other staphylococcal exotoxins, TSST-1 has diverse immunological effects [8].
• We have assessed metabolic and immunological effects of a nelfinavir-containing regimen in healthy HIV-1-uninfected individuals receiving post-exposure prophylaxis [9].
• Polyinosinic-polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose in combination with interleukin 2 in patients with cancer: clinical and immunological effects [10].

Chemical compound and disease context of Immunity

• Phase I study of the novel cyclic AMP (cAMP) analogue 8-chloro-cAMP in patients with cancer: toxicity, hormonal, and immunological effects [11].
• BACKGROUND: A phase II study was performed to evaluate the clinical and immunological effects of a regimen of fluorouracil (5-FU) and folinic acid (FA) combined with thymopentin (TP-5) and interleukin-2 (IL-2) in the treatment of patients with metastatic colorectal cancer [12].
• Methionine-enkephalin as immunomodulator therapy in human immunodeficiency virus infections: clinical and immunological effects [13].
• Sequential dacarbazine/cisplatin and interleukin-2 in metastatic melanoma: immunological effects of therapy [14].
• We examined the immunological effects of dexrazoxane in combination with mitoxantrone in experimental autoimmune encephalomyelitis (EAE) in Lewis rats [15].

Biological context of Immunity

• Disregulation of vitamin A metabolism is able to generate different immunological effects, including altered response to infection, reduced IgG production, and differential regulation of cytokine gene expression (including interleukin-2 and -4 and interferon-gamma (IFN-gamma)) [16].
• The steady increment of IL-10 plasma levels may mediate the observed down-regulation of clinical and immunological effects [17].
• Pharmacokinetics and immunological effects of exogenously administered recombinant human B lymphocyte stimulator (BLyS) in mice [18].
• In this study, immunological effects of pair-feeding a 35% ethanol-containing Bio-Serv liquid diet for 6 weeks were evaluated using two major histocompatibility complex (MHC)-compatible inbred strains of rats (F344 and LEW) [19].
• Purpose: We conducted a phase I trial of interleukin 2 (IL-2) in combination with chimeric 14.18 (ch14.18) and murine R24 antibodies to determine the maximal tolerated dose (MTD), immunological effects, and toxicity of this treatment combination [20].

Anatomical context of Immunity

• Because alkyl-lysophospholipids target the cell membrane as their site of action, our aim was to analyse the immunological effects of a nonlethal ALP treatment on leukemic K562 cells [21].
• In this open-label, dose-escalating study, we examined the pharmacokinetic (PK), clinical, biological and immunological effects of a humanized IgG1 anti-CD4 monoclonal antibody (mAb), 4162W94, in the peripheral blood (PB) and synovial fluid (SF) of RA patients [22].
• In order to define peptide epitope(s) that may be critical for eliciting an immune response sufficient to effect immunological contraception without causing any adverse effects on ovarian physiology, studies have been carried out to identify immunodominant B-cell epitopes of the ZP1 protein [23].
• Erythrocyte alloantigen diversity and some immunological effects of the B system in related New Hampshire strains [24].
• Studies on the immunological effects of fatty alcohols--I. Effects of n-hexacosanol on murine macrophages in culture [25].

Associations of Immunity with chemical compounds

• In such patients clinical and immunological effects of Isoprinosine have already been reported by others [26].
• Immunological effects of flavone acetic acid [27].
• The metabolic and immunological effects of cyclosporin given to prevent diabetes in BB rats were examined [28].
• SUMMARY: In two independent studies in patients with limited antiretroviral treatment experience, remarkably similar results were obtained when 3TC/zidovudine in combination was compared to zidovudine monotherapy, demonstrating sustained antiretroviral and immunological effects of the combination over the 48 and 52 weeks of study [29].
• Immunological effects of thalidomide and its chemical and functional analogs [30].

Gene context of Immunity

• To characterize the immunological effects of intermittent IL-2 therapy, which leads to selective increases in CD4+ T lymphocytes in HIV-infected patients, 11 patients underwent extensive immunological evaluation [31].
• It is well documented that neuropeptide Y (NPY) exerts a wide range of biological functions through at least five NPY Y receptor subtypes (Y1-Y5), but its immunological effects only recently came into focus [32].
• Thus, immunological effects of IFN-beta1a and GA were similar showing that disease promoting Th1 (IFN-gamma) cells were reduced while the potentially beneficial Th2 response (IL-4) was maintained [33].
• BACKGROUND: Interleukin-6 (IL-6) has multiple immunological effects on a wide variety of cells and tissues [34].
• To determine the immunological effect on the resistance in vivo, we infected immunologically immature newborn mice homozygous (Fv-4(r/r)) and heterozygous (Fv-4(r/-)) for Fv-4 [35].

Analytical, diagnostic and therapeutic context of Immunity

• A prospective randomized study of the immunological effects of three total parenteral nutrition (TPN) regimens in patients undergoing preoperative parenteral nutrition was conducted [36].
• OBJECTIVES: In a phase I study the feasibility, toxicity and immunological effects of peri-operative cytokine immunotherapy of renal cell carcinoma were studied [37].
• Short communication: No detrimental immunological effects of mycophenolate mofetil and HAART in treatment-naive acute and chronic HIV-1-infected patients [38].
• Conjugated linoleic acid (CLA) has shown beneficial properties in animal models including anti-cancer, anti-atherogenic and anti-diabetic effects, while contrasting immunological effects were reported [39].
• Two analogs of thymosin beta 4 the N-terminal acetyl groups of which were substituted by Ala or D-Ala, were synthesized by the solution method and studied for their immunological effect on the impaired blastogenic response of T-lymphocytes isolated from uremic patients after treatment of human serum [40].

References