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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD.

Cytokines often deliver simultaneous, yet distinct, cell growth and cell survival signals. The 70-kDa ribosomal protein S6 kinase (p70S6K) is known to regulate cell growth by inducing protein synthesis components. We purified membrane-based p70S6K as a kinase responsible for site-specific phosphorylation of BAD, which inactivates this proapoptotic molecule. Rapamycin inhibited mitochondrial-based p70S6K, which prevented phosphorylation of Ser-136 on BAD and blocked cell survival induced by insulin-like growth factor 1 (IGF-1). Moreover, IGF-1- induced phosphorylation of BAD Ser-136 was abolished in p70S6K-deficient cells. Thus, p70S6K is itself a dual pathway kinase, signaling cell survival as well as growth through differential substrates which include mitochondrial BAD and the ribosomal subunit S6, respectively.[1]

References

  1. p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Harada, H., Andersen, J.S., Mann, M., Terada, N., Korsmeyer, S.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
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