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Gene Review

Rps6  -  ribosomal protein S6

Rattus norvegicus

Synonyms: 40S ribosomal protein S6
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Disease relevance of Rps6


High impact information on Rps6


Chemical compound and disease context of Rps6


Biological context of Rps6


Anatomical context of Rps6


Associations of Rps6 with chemical compounds


Physical interactions of Rps6


Enzymatic interactions of Rps6


Regulatory relationships of Rps6


Other interactions of Rps6


Analytical, diagnostic and therapeutic context of Rps6


  1. The mammalian RPS6 gene, homolog of the Drosophila air8 tumor suppressor gene: is it an oncosuppressor gene? Lecomte, F., Champagne, B., Dasnoy, J.F., Szpirer, J., Szpirer, C. Somat. Cell Mol. Genet. (1995) [Pubmed]
  2. Studies of partially transforming polyomavirus mutants establish a role for phosphatidylinositol 3-kinase in activation of pp70 S6 kinase. Dahl, J., Freund, R., Blenis, J., Benjamin, T.L. Mol. Cell. Biol. (1996) [Pubmed]
  3. Differential effect of sepsis on ability of leucine and IGF-I to stimulate muscle translation initiation. Lang, C.H., Frost, R.A. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  4. Ribosomal protein S6 kinase and protein kinase C activation by epidermal growth factor after temporary renal ischemia. Alberti, P., Bardella, L., Comolli, R. Nephron (1993) [Pubmed]
  5. Protein synthesis, ribosomal protein S6 phosphorylation in vitro and the effects of amiloride: SDS gel electrophoresis studies in the Yoshida ascites tumor (AH 130) grown in vivo. Comolli, R., Leonardi, M.G., Alberti, P., Frigerio, M. Cell Biol. Int. Rep. (1986) [Pubmed]
  6. Nerve growth factor mediates phosphorylation of specific proteins. Halegoua, S., Patrick, J. Cell (1980) [Pubmed]
  7. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Dudek, H., Datta, S.R., Franke, T.F., Birnbaum, M.J., Yao, R., Cooper, G.M., Segal, R.A., Kaplan, D.R., Greenberg, M.E. Science (1997) [Pubmed]
  8. p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Harada, H., Andersen, J.S., Mann, M., Terada, N., Korsmeyer, S.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  9. Insulin activates a 70-kDa S6 kinase through serine/threonine-specific phosphorylation of the enzyme polypeptide. Price, D.J., Gunsalus, J.R., Avruch, J. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  10. Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin. Morgan, D.O., Roth, R.A. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  11. Hormonally inducible phosphorylation of a nuclear pool of ribosomal protein S6. Franco, R., Rosenfeld, M.G. J. Biol. Chem. (1990) [Pubmed]
  12. The primary structure of rat ribosomal protein S6. Chan, Y.L., Wool, I.G. J. Biol. Chem. (1988) [Pubmed]
  13. Characterization of insulin-stimulated seryl/threonyl protein kinases in rat skeletal muscle. Hei, Y.J., McNeill, J.H., Sanghera, J.S., Diamond, J., Bryer-Ash, M., Pelech, S.L. J. Biol. Chem. (1993) [Pubmed]
  14. Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. Blommaart, E.F., Luiken, J.J., Blommaart, P.J., van Woerkom, G.M., Meijer, A.J. J. Biol. Chem. (1995) [Pubmed]
  15. Activation of ribosomal protein S6 kinases does not increase glycogen synthesis or glucose transport in rat adipocytes. Lin, T.A., Lawrence, J.C. J. Biol. Chem. (1994) [Pubmed]
  16. Purification and characterization of a novel ribosomal S6 kinase from skeletal muscle of insulin-treated rats. Hei, Y.J., Pelech, S.L., Chen, X., Diamond, J., McNeill, J.H. J. Biol. Chem. (1994) [Pubmed]
  17. An activated S6 kinase in extracts from serum- and epidermal growth factor-stimulated Swiss 3T3 cells. Novak-Hofer, I., Thomas, G. J. Biol. Chem. (1984) [Pubmed]
  18. Follicle-stimulating hormone activates p70 ribosomal protein S6 kinase by protein kinase A-mediated dephosphorylation of Thr 421/Ser 424 in primary Sertoli cells. Lécureuil, C., Tesseraud, S., Kara, E., Martinat, N., Sow, A., Fontaine, I., Gauthier, C., Reiter, E., Guillou, F., Crépieux, P. Mol. Endocrinol. (2005) [Pubmed]
  19. Insulin receptors mediate growth effects in cultured fetal neurons. II. Activation of a protein kinase that phosphorylates ribosomal protein S6. Heidenreich, K.A., Toledo, S.P. Endocrinology (1989) [Pubmed]
  20. Purification of a hepatic S6 kinase from cycloheximide-treated Rats. Price, D.J., Nemenoff, R.A., Avruch, J. J. Biol. Chem. (1989) [Pubmed]
  21. Regulation of S6 kinase activity in Madin-Darby canine kidney renal epithelial cells. Meier, K.E., Weiel, J.E., Bloom, T.J., Krebs, E.G. J. Biol. Chem. (1990) [Pubmed]
  22. Resveratrol suppresses angiotensin II-induced Akt/protein kinase B and p70 S6 kinase phosphorylation and subsequent hypertrophy in rat aortic smooth muscle cells. Haider, U.G., Sorescu, D., Griendling, K.K., Vollmar, A.M., Dirsch, V.M. Mol. Pharmacol. (2002) [Pubmed]
  23. Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes. Wang, L., Rolfe, M., Proud, C.G. Biochem. J. (2003) [Pubmed]
  24. Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue. Lynch, C.J., Patson, B.J., Anthony, J., Vaval, A., Jefferson, L.S., Vary, T.C. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  25. Inhibition of nitric oxide synthesis induces coronary vascular remodeling and cardiac hypertrophy associated with the activation of p70 S6 kinase in rats. Minamino, T., Kitakaze, M., Papst, P.J., Ueda, Y., Sakata, Y., Asanuma, H., Ogai, A., Kuzuya, T., Terada, N., Hori, M. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. (2000) [Pubmed]
  26. Activation of S6 kinase activity in astrocytes by insulin, somatomedin C and TPA. Pierre, M., Toru-Delbauffe, D., Gavaret, J.M., Pomerance, M., Jacquemin, C. FEBS Lett. (1986) [Pubmed]
  27. Ribosomal protein S6 kinase is activated after folic acid injury and epidermal growth factor administration but not after unilateral nephrectomy in the rat kidney. Alberti, P., Bardella, L., Comolli, R. Nephron (1992) [Pubmed]
  28. Acute attenuation of translation initiation and protein synthesis by glucocorticoids in skeletal muscle. Shah, O.J., Kimball, S.R., Jefferson, L.S. Am. J. Physiol. Endocrinol. Metab. (2000) [Pubmed]
  29. Differential effects of acute and chronic exposure to interferon-gamma on cyclic adenosine 3',5'-monophosphate response element-regulated gene expression. Saavedra, A.P., Cass, L.A., Prendergast, G.V., Meinkoth, J.L. Endocrinology (2000) [Pubmed]
  30. Differential phosphorylation of ribosomal protein S6 in isolated rat hepatocytes after incubation with insulin and glucagon. Wettenhall, R.E., Cohen, P., Caudwell, B., Holland, R. FEBS Lett. (1982) [Pubmed]
  31. Beta-adrenergic receptors (betaAR) regulate cardiomyocyte proliferation during early postnatal life. Tseng, Y.T., Kopel, R., Stabila, J.P., McGonnigal, B.G., Nguyen, T.T., Gruppuso, P.A., Padbury, J.F. FASEB J. (2001) [Pubmed]
  32. Activation of signaling pathways and regulatory mechanisms of mRNA translation following myocardial ischemia-reperfusion. Crozier, S.J., Zhang, X., Wang, J., Cheung, J., Kimball, S.R., Jefferson, L.S. J. Appl. Physiol. (2006) [Pubmed]
  33. Protein kinase signaling pathway triggered by cell swelling and involved in the activation of glycogen synthase and acetyl-CoA carboxylase in isolated rat hepatocytes. Krause, U., Rider, M.H., Hue, L. J. Biol. Chem. (1996) [Pubmed]
  34. Clofibrate treatment promotes branched-chain amino acid catabolism and decreases the phosphorylation state of mTOR, eIF4E-BP1, and S6K1 in rat liver. Ishiguro, H., Katano, Y., Nakano, I., Ishigami, M., Hayashi, K., Honda, T., Goto, H., Bajotto, G., Maeda, K., Shimomura, Y. Life Sci. (2006) [Pubmed]
  35. Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte. Chan, A.Y., Soltys, C.L., Young, M.E., Proud, C.G., Dyck, J.R. J. Biol. Chem. (2004) [Pubmed]
  36. An S6 kinase activated during liver regeneration is related to the insulin-stimulated S6 kinase in H4 hepatoma cells. Nemenoff, R.A., Price, D.J., Mendelsohn, M.J., Carter, E.A., Avruch, J. J. Biol. Chem. (1988) [Pubmed]
  37. Insulin and ribosomal protein S6 kinase in rat pancreatic acini. Sung, C.K., Williams, J.A. Diabetes (1989) [Pubmed]
  38. The regulation of hepatic protein synthesis during fasting in the rat. Anand, P., Gruppuso, P.A. J. Biol. Chem. (2005) [Pubmed]
  39. Insulin- and phorbol ester-stimulated phosphorylation of ribosomal protein S6. Trevillyan, J.M., Perisic, O., Traugh, J.A., Byus, C.V. J. Biol. Chem. (1985) [Pubmed]
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