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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Corticosteroids depress IFN-alpha-producing plasmacytoid dendritic cells in human blood.

Glucocorticoids are strongly immunosuppressive and are associated with reactivation of some intracellular infections. The plasmacytoid dendritic cell is a rare blood mononuclear cell detected through its production of IFN-alpha in response to herpes simplex virus and by surface immunophenotyping. We here report that steroid administration results in a decrease of IFN-alpha generation of approximately 25-fold, accompanied by reduction in circulating plasmacytoid dendritic cell numbers. Both parameters return to normal within days after steroid cessation.[1]

References

  1. Corticosteroids depress IFN-alpha-producing plasmacytoid dendritic cells in human blood. Shodell, M., Siegal, F.P. J. Allergy Clin. Immunol. (2001) [Pubmed]
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