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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Immunophenotyping


High impact information on Immunophenotyping

  • IL-15(-/-) mice lacked NK cells, as assessed by both immunophenotyping and functional criteria, indicating an obligate role for IL-15 in the development and functional maturation of NK cells [6].
  • Informed consent was obtained for studies that entailed CD4 lymphocyte counts, immunophenotyping, isolator blood cultures, and radiological scans [7].
  • Since the technique can be used on blood and marrow smears even after storage or postal transport, it is suggested that APAAP labelling should become the method of choice for immunophenotyping neoplastic samples in many haematology laboratories not equipped with specialised immunological diagnostic facilities [8].
  • In this study we used myeloid colony assays, immunophenotyping, and transplantation to evaluate myelopoiesis in Mll-AF9 mice [9].
  • Criteria for diagnosis and subclassification of these lesions include peripheral blood findings, cytologic features of hematopoietic tissues, histopathology, immunophenotyping, genetic features, and clinical course [10].

Chemical compound and disease context of Immunophenotyping


Biological context of Immunophenotyping


Anatomical context of Immunophenotyping


Associations of Immunophenotyping with chemical compounds

  • For immunophenotyping, sections were incubated, fixed, and stained with fluorescein isothiocyanate-labeled antibodies [23].
  • Immunophenotyping of insulitis in control and essential fatty acid deficient mice treated with multiple low-dose streptozotocin [24].
  • METHODS: Serial immunophenotyping was performed and cytokine measurements were obtained in the peripheral blood and CSF of 12 European patients with definite B burgdorferi meningoradiculitis [25].
  • Induction of clinical remission in T-large granular lymphocyte leukemia with cyclosporin A, monitored by use of immunophenotyping with Vbeta antibodies [26].
  • Although an artifactual signet ring appearance of the blasts was found in the formalin-fixed tissue and caused diagnostic problems, the histological appearance on B-5 fixed material and immunophenotyping confirmed the diagnosis [27].

Gene context of Immunophenotyping

  • Expression profiling using microarrays, which was selectively validated and extended by immunophenotyping of Neu*-induced PIN and CAP, led to the identification of some novel biomarkers and also revealed increased expression of Egfr, Erbb3 and phosphorylated androgen receptor [28].
  • RESULTS: Immunophenotyping showed a low expression of CD80 and CD40 and a variable CD86 expression on most AML cells [29].
  • In conclusion, the study of erythroid marker expression is of particular importance when immunophenotyping leukaemic cells with a proerythroblast-like morphology or an undifferentiated aspect and a HLA DR-, CD36++, B-, T-, My- (CD33 +/-) phenotype [30].
  • Immunophenotyping showed positivity with CD33, CD34 and intracellular MPO, but all lymphoid markers tested were negative [31].
  • Immunophenotyping showed BCP type III pre-B cell characteristics including TdT, CD10, CD19, CD22, CD79a and HLA class II [32].

Analytical, diagnostic and therapeutic context of Immunophenotyping


  1. Aplastic anemia and viral hepatitis. Non-A, Non-B, Non-C? Hibbs, J.R., Frickhofen, N., Rosenfeld, S.J., Feinstone, S.M., Kojima, S., Bacigalupo, A., Locasciulli, A., Tzakis, A.G., Alter, H.J., Young, N.S. JAMA (1992) [Pubmed]
  2. Corticosteroids depress IFN-alpha-producing plasmacytoid dendritic cells in human blood. Shodell, M., Siegal, F.P. J. Allergy Clin. Immunol. (2001) [Pubmed]
  3. Analysis of cyclin D1 expression by quantitative real-time reverse transcription-polymerase chain reaction in the diagnosis of mantle cell lymphoma. Peghini, P.E., Fehr, J. Am. J. Clin. Pathol. (2002) [Pubmed]
  4. Monoclonal antibody study of Philadelphia chromosome-positive blastic leukemias using the alkaline phosphatase anti-alkaline phosphatase (APAAP) technic. Neumann, M.P., de Solas, I., Parkin, J.L., Gajl-Peczalska, K., McKenna, R.W., Berkley, C.K., Nichols, W.L., Brunning, R.D. Am. J. Clin. Pathol. (1986) [Pubmed]
  5. Ki-1-positive anaplastic large-cell lymphoma can mimic benign dermatoses. Camisa, C., Helm, T.N., Sexton, C., Tuthill, R. J. Am. Acad. Dermatol. (1993) [Pubmed]
  6. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. Kennedy, M.K., Glaccum, M., Brown, S.N., Butz, E.A., Viney, J.L., Embers, M., Matsuki, N., Charrier, K., Sedger, L., Willis, C.R., Brasel, K., Morrissey, P.J., Stocking, K., Schuh, J.C., Joyce, S., Peschon, J.J. J. Exp. Med. (2000) [Pubmed]
  7. Focal mycobacterial lymphadenitis following initiation of protease-inhibitor therapy in patients with advanced HIV-1 disease. Race, E.M., Adelson-Mitty, J., Kriegel, G.R., Barlam, T.F., Reimann, K.A., Letvin, N.L., Japour, A.J. Lancet (1998) [Pubmed]
  8. APAAP labelling of blood and bone-marrow samples for phenotyping leukaemia. Erber, W.N., Mynheer, L.C., Mason, D.Y. Lancet (1986) [Pubmed]
  9. Prenatal and postnatal myeloid cells demonstrate stepwise progression in the pathogenesis of MLL fusion gene leukemia. Johnson, J.J., Chen, W., Hudson, W., Yao, Q., Taylor, M., Rabbitts, T.H., Kersey, J.H. Blood (2003) [Pubmed]
  10. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Kogan, S.C., Ward, J.M., Anver, M.R., Berman, J.J., Brayton, C., Cardiff, R.D., Carter, J.S., de Coronado, S., Downing, J.R., Fredrickson, T.N., Haines, D.C., Harris, A.W., Harris, N.L., Hiai, H., Jaffe, E.S., MacLennan, I.C., Pandolfi, P.P., Pattengale, P.K., Perkins, A.S., Simpson, R.M., Tuttle, M.S., Wong, J.F., Morse, H.C. Blood (2002) [Pubmed]
  11. Immunohistochemical characterization of lymphosarcoma in two alpacas (Lama pacos). Hemsley, S., Bailey, G., Canfield, P. J. Comp. Pathol. (2002) [Pubmed]
  12. Regression of subcutaneous lymphoma following removal of an ovarian granulosatheca cell tumor in a horse. Henson, K.L., Alleman, A.R., Cutler, T.J., Ginn, P.E., Kelley, L.C. J. Am. Vet. Med. Assoc. (1998) [Pubmed]
  13. The contribution of cytochemistry and immunophenotyping to the reproducibility of the FAB classification in acute leukemia. Browman, G.P., Neame, P.B., Soamboonsrup, P. Blood (1986) [Pubmed]
  14. Identification of an unusual Fc gamma receptor IIIa (CD16) on natural killer cells in a patient with recurrent infections. de Vries, E., Koene, H.R., Vossen, J.M., Gratama, J.W., von dem Borne, A.E., Waaijer, J.L., Haraldsson, A., de Haas, M., van Tol, M.J. Blood (1996) [Pubmed]
  15. Survival of patients with glioblastoma multiforme is not influenced by altered expression of p16, p53, EGFR, MDM2 or Bcl-2 genes. Newcomb, E.W., Cohen, H., Lee, S.R., Bhalla, S.K., Bloom, J., Hayes, R.L., Miller, D.C. Brain Pathol. (1998) [Pubmed]
  16. Tacrolimus ointment causes inflammatory dendritic epidermal cell depletion but no Langerhans cell apoptosis in patients with atopic dermatitis. Schuller, E., Oppel, T., Bornhövd, E., Wetzel, S., Wollenberg, A. J. Allergy Clin. Immunol. (2004) [Pubmed]
  17. The flow cytometric pattern of CD34, CD15 and CD13 expression in acute myeloblastic leukemia is highly characteristic of the presence of PML-RARalpha gene rearrangements. Orfao, A., Chillón, M.C., Bortoluci, A.M., López-Berges, M.C., García-Sanz, R., Gonzalez, M., Tabernero, M.D., García-Marcos, M.A., Rasillo, A.I., Hernández-Rivas, J., San Miguel, J.F. Haematologica (1999) [Pubmed]
  18. Fibroblasts from human spleen regulate NK cell differentiation from blood CD34(+) progenitors via cell surface IL-15. Briard, D., Brouty-Boyé, D., Azzarone, B., Jasmin, C. J. Immunol. (2002) [Pubmed]
  19. Translocation t(2;7)(p12;q21-22) with dysregulation of the CDK6 gene mapping to 7q21-22 in a non-Hodgkin's lymphoma with leukemia. Brito-Babapulle, V., Gruszka-Westwood, A.M., Platt, G., Andersen, C.L., Elnenaei, M.O., Matutes, E., Wotherspoon, A.C., Weston-Smith, S.G., Catovsky, D. Haematologica (2002) [Pubmed]
  20. CD5+ T-cell/histiocyte-rich large B-cell lymphoma. Chang, C.C., Bunyi-Teopengco, E., Eshoa, C., Chitambar, C.R., Kampalath, B. Mod. Pathol. (2002) [Pubmed]
  21. Flow cytometric enumeration and immunophenotyping of hematopoietic stem and progenitor cells. Gratama, J.W., Sutherland, D.R., Keeney, M. Semin. Hematol. (2001) [Pubmed]
  22. Evaluation of an alternative to the Kolmogorov-Smirnov test for flow cytometric histogram comparisons. Parikh, H.H., Li, W.C., Ramanathan, M. J. Immunol. Methods (1999) [Pubmed]
  23. Intracellular free radical production in synovial T lymphocytes from patients with rheumatoid arthritis. Remans, P.H., van Oosterhout, M., Smeets, T.J., Sanders, M., Frederiks, W.M., Reedquist, K.A., Tak, P.P., Breedveld, F.C., van Laar, J.M. Arthritis Rheum. (2005) [Pubmed]
  24. Immunophenotyping of insulitis in control and essential fatty acid deficient mice treated with multiple low-dose streptozotocin. Fraser, R.B., Rowden, G., Colp, P., Wright, J.R. Diabetologia (1997) [Pubmed]
  25. The immune response at onset and during recovery from Borrelia burgdorferi meningoradiculitis. Cepok, S., Zhou, D., Vogel, F., Rosche, B., Grummel, V., Sommer, N., Hemmer, B. Arch. Neurol. (2003) [Pubmed]
  26. Induction of clinical remission in T-large granular lymphocyte leukemia with cyclosporin A, monitored by use of immunophenotyping with Vbeta antibodies. Brinkman, K., van Dongen, J.J., van Lom, K., Groeneveld, K., Miseré, J.F., van der Heul, C. Leukemia (1998) [Pubmed]
  27. Granulocytic sarcoma of megakaryoblastic differentiation complicating chronic idiopathic myelofibrosis. Chan, A.C., Kwong, Y.L., Lam, C.C. Hum. Pathol. (1996) [Pubmed]
  28. Prostatic intraepithelial neoplasia and adenocarcinoma in mice expressing a probasin-Neu oncogenic transgene. Li, Z., Szabolcs, M., Terwilliger, J.D., Efstratiadis, A. Carcinogenesis (2006) [Pubmed]
  29. Expression and induction of costimulatory and adhesion molecules on acute myeloid leukemic cells: implications for adoptive immunotherapy. Brouwer, R.E., Zwinderman, K.H., Kluin-Nelemans, H.C., van Luxemburg-Heijs, S.A., Willemze, R., Falkenburg, J.H. Exp. Hematol. (2000) [Pubmed]
  30. Minimally differentiated erythroleukaemia (AML M6 'variant'): a rare subset of AML distinct from AML M6. Groupe Français d'Hématologie Cellulaire. Garand, R., Duchayne, E., Blanchard, D., Robillard, N., Kuhlein, E., Fenneteau, O., Salomon-Nguyen, F., Grange, M.J., Rousselot, P., Demur, C. Br. J. Haematol. (1995) [Pubmed]
  31. Isolated tetrasomy 8 in minimally differentiated acute myeloid leukemia (AML-M0). Xue, Y., Guo, Y., Zhou, Y., Xie, X., Zheng, L., Shen, M. Leuk. Lymphoma (1999) [Pubmed]
  32. Establishment of novel B-cell precursor leukemia sister cell lines NALM-36 and NALM-37: shift of immunoglobulin phenotype to double light chain positive B-cell. Matsuo, Y., Drexler, H.G., Takeuchi, M., Orita, K. Leuk. Res. (2002) [Pubmed]
  33. Gating strategy for immunophenotyping of leukemia and lymphoma. Sun, T., Sangaline, R., Ryder, J., Gibbens, K., Rollo, C., Stewart, S., Rajagopalan, C. Am. J. Clin. Pathol. (1997) [Pubmed]
  34. Radiation dose-dependent increases in inflammatory response markers in A-bomb survivors. Hayashi, T., Kusunoki, Y., Hakoda, M., Morishita, Y., Kubo, Y., Maki, M., Kasagi, F., Kodama, K., Macphee, D.G., Kyoizumi, S. Int. J. Radiat. Biol. (2003) [Pubmed]
  35. Simultaneous detection of X and Y chromosomes by two-colour fluorescence in situ hybridization in combination with immunophenotyping of single cells to document chimaerism after sex-mismatched bone marrow transplantation. van Tol, M.J., Langlois van den Bergh, R., Mesker, W., Ouwerkerk-van Velzen, M.C., Vossen, J.M., Tanke, H.J. Bone Marrow Transplant. (1998) [Pubmed]
  36. Acute myeloid leukaemia expressing the leucocyte integrin CD11b-a new leukaemic syndrome with poor prognosis: result of an ECOG database analysis. Eastern Cooperative Oncology Group. Paietta, E., Andersen, J., Yunis, J., Rowe, J.M., Cassileth, P.A., Tallman, M.S., Bennett, J.M., Wiernik, P.H. Br. J. Haematol. (1998) [Pubmed]
  37. Regenerating normal B-cell precursors during and after treatment of acute lymphoblastic leukaemia: implications for monitoring of minimal residual disease. van Wering, E.R., van der Linden-Schrever, B.E., Szczepański, T., Willemse, M.J., Baars, E.A., van Wijngaarde-Schmitz, H.M., Kamps, W.A., van Dongen, J.J. Br. J. Haematol. (2000) [Pubmed]
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