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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Decreased platelet [3H]paroxetine binding sites in suicide attempters.

Research to date would suggest the possible involvement of the serotonin (5-HT) system in the pathophysiology of suicide. With this study, we aimed to investigate the platelet 5-HT transporter, by means of the specific binding of tritiated paroxetine ([3H]Par), in a sample of 20 suicide attempters recruited at a first-aid service, as compared with healthy control subjects and psychiatric patients with no current or previous history of suicide attempt. The results, showing a decreased number of [3H]Par binding sites in suicide attempters, would suggest the involvement of the presynaptic 5-HT transporter in self-aggressive behavior.[1]


  1. Decreased platelet [3H]paroxetine binding sites in suicide attempters. Marazziti, D., Dell'Osso, L., Rossi, A., Masala, I., Baroni, S., Armani, A., Giannaccini, G., Di Nasso, E., Lucacchini, A., Cassano, G.B. Psychiatry research. (2001) [Pubmed]
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