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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

The mouse Fgfrl1 gene coding for a novel FGF receptor-like protein.

The mouse Fgfrl1 gene codes for a novel cell surface protein that is closely related to the family of the FGF receptors. It contains three extracellular Ig C2 loops and an acidic box, which share 29-33% sequence identity (48-50% similarity) with FGF receptors 1-4. The intracellular portion of the novel protein, however, lacks a tyrosine kinase domain required for signal transduction by transphosphorylation. The gene for Fgfrl1 comprises six exons and is located on mouse chromosome 5 in close proximity to the Idua gene for L-iduronidase.[1]

References

  1. The mouse Fgfrl1 gene coding for a novel FGF receptor-like protein. Wiedemann, M., Trueb, B. Biochim. Biophys. Acta (2001) [Pubmed]
 
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