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Gene Review

Idua  -  iduronidase, alpha-L-

Mus musculus

Synonyms: Alpha-L-iduronidase
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Disease relevance of Idua


Psychiatry related information on Idua

  • The results indicate that Idua(-/-) mice present deficits in long-term memory for aversive training and reduced exploratory behavior [1].

High impact information on Idua

  • Sham-treated mice received Idua-/- bone marrow that was either unmodified or transduced with eGFP [4].
  • As expected, both Idua and D4S115h are located on the proximal portion of mouse Chr 5 near homologs for other loci on human Chr 4p [5].
  • The gene for Fgfrl1 comprises six exons and is located on mouse chromosome 5 in close proximity to the Idua gene for L-iduronidase [6].


  1. Long-term memory for aversive training is impaired in Idua(-/-) mice, a genetic model of mucopolysaccharidosis type I. Reolon, G.K., Braga, L.M., Camassola, M., Luft, T., Henriques, J.A., Nardi, N.B., Roesler, R. Brain Res. (2006) [Pubmed]
  2. Murine mucopolysaccharidosis type I: targeted disruption of the murine alpha-L-iduronidase gene. Clarke, L.A., Russell, C.S., Pownall, S., Warrington, C.L., Borowski, A., Dimmick, J.E., Toone, J., Jirik, F.R. Hum. Mol. Genet. (1997) [Pubmed]
  3. Correction of metabolic, craniofacial, and neurologic abnormalities in MPS I mice treated at birth with adeno-associated virus vector transducing the human alpha-L-iduronidase gene. Hartung, S.D., Frandsen, J.L., Pan, D., Koniar, B.L., Graupman, P., Gunther, R., Low, W.C., Whitley, C.B., McIvor, R.S. Mol. Ther. (2004) [Pubmed]
  4. Treatment of the mouse model of mucopolysaccharidosis I with retrovirally transduced bone marrow. Zheng, Y., Rozengurt, N., Ryazantsev, S., Kohn, D.B., Satake, N., Neufeld, E.F. Mol. Genet. Metab. (2003) [Pubmed]
  5. Linkage, but not gene order, of homologous loci, including alpha-L-iduronidase (Idua), is conserved in the Huntington disease region of the mouse and human genomes. Koizumi, T., MacDonald, M., Búcan, M., Hopwood, J.J., Morris, C.P., Scott, H.S., Gusella, J.F., Nadeau, J.H. Mamm. Genome (1992) [Pubmed]
  6. The mouse Fgfrl1 gene coding for a novel FGF receptor-like protein. Wiedemann, M., Trueb, B. Biochim. Biophys. Acta (2001) [Pubmed]
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