The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt

Table of contents

About

Terms

 

Gene Review: 

Idua  -  iduronidase, alpha-L-

Mus musculus

Synonyms: Alpha-L-iduronidase
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Idua

 

Psychiatry related information on Idua

  • The results indicate that Idua(-/-) mice present deficits in long-term memory for aversive training and reduced exploratory behavior [1].
 

High impact information on Idua

  • Sham-treated mice received Idua-/- bone marrow that was either unmodified or transduced with eGFP [4].
  • As expected, both Idua and D4S115h are located on the proximal portion of mouse Chr 5 near homologs for other loci on human Chr 4p [5].
  • The gene for Fgfrl1 comprises six exons and is located on mouse chromosome 5 in close proximity to the Idua gene for L-iduronidase [6].

References

  1. Long-term memory for aversive training is impaired in Idua(-/-) mice, a genetic model of mucopolysaccharidosis type I. Reolon, G.K., Braga, L.M., Camassola, M., Luft, T., Henriques, J.A., Nardi, N.B., Roesler, R. Brain Res. (2006) [Pubmed]
  2. Murine mucopolysaccharidosis type I: targeted disruption of the murine alpha-L-iduronidase gene. Clarke, L.A., Russell, C.S., Pownall, S., Warrington, C.L., Borowski, A., Dimmick, J.E., Toone, J., Jirik, F.R. Hum. Mol. Genet. (1997) [Pubmed]
  3. Correction of metabolic, craniofacial, and neurologic abnormalities in MPS I mice treated at birth with adeno-associated virus vector transducing the human alpha-L-iduronidase gene. Hartung, S.D., Frandsen, J.L., Pan, D., Koniar, B.L., Graupman, P., Gunther, R., Low, W.C., Whitley, C.B., McIvor, R.S. Mol. Ther. (2004) [Pubmed]
  4. Treatment of the mouse model of mucopolysaccharidosis I with retrovirally transduced bone marrow. Zheng, Y., Rozengurt, N., Ryazantsev, S., Kohn, D.B., Satake, N., Neufeld, E.F. Mol. Genet. Metab. (2003) [Pubmed]
  5. Linkage, but not gene order, of homologous loci, including alpha-L-iduronidase (Idua), is conserved in the Huntington disease region of the mouse and human genomes. Koizumi, T., MacDonald, M., Búcan, M., Hopwood, J.J., Morris, C.P., Scott, H.S., Gusella, J.F., Nadeau, J.H. Mamm. Genome (1992) [Pubmed]
  6. The mouse Fgfrl1 gene coding for a novel FGF receptor-like protein. Wiedemann, M., Trueb, B. Biochim. Biophys. Acta (2001) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities