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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cat-scratch disease neuroretinitis diagnosed by a polymerase chain reaction approach.

PURPOSE: To assess the value of polymerase chain reaction in the diagnosis of cat-scratch disease neuroretinitis without conclusive serology. METHODS: Interventional case report. A 13-year-old girl developed a right neuroretinitis 2 months after a cat scratch. Despite the lack of accompanying features, an infection by Bartonella henselae was suspected and a systemic check-up was performed. RESULTS: Serologic results excluded other proposed origins but were insufficient in making the diagnosis because of low B. henselae specific IgG level in serum. A polymerase chain reaction analysis for B. henselae DNA in a small axillary lymphadenopathy aspirate enabled us to achieve a definitive diagnosis of cat-scratch disease. CONCLUSION: Polymerase chain reaction is a valuable method of diagnosing cat-scratch disease when serology is considered negative or borderline.[1]


  1. Cat-scratch disease neuroretinitis diagnosed by a polymerase chain reaction approach. Labalette, P., Bermond, D., Dedes, V., Savage, C. Am. J. Ophthalmol. (2001) [Pubmed]
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