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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cat-Scratch Disease

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Disease relevance of Cat-Scratch Disease


High impact information on Cat-Scratch Disease


Chemical compound and disease context of Cat-Scratch Disease


Biological context of Cat-Scratch Disease


Gene context of Cat-Scratch Disease

  • Levels of circulating interleukin (IL)-2, IL-6, and IL-10, measured by enzyme-linked immunosorbent assay, were significantly higher in patients with cat scratch disease (CSD) than in healthy control subjects; no induction of IL-12 was observed, and levels of interferon-gamma and IL-4 were generally not detectable [16].
  • We speculate that the immunological changes associated with cat scratch disease in this patient may have triggered the development of IgA nephropathy [17].
  • BACKGROUND: We report a case of ocular cat-scratch disease with permanent vision reduction in a patient who was cytoplasmic anti-neutrophil cytoplasmic antibody (C-ANCA) positive [18].
  • Cat scratch disease was known to afflict primarily children and adolescent; however, the incidence of CSD is increasing in immunocompromised groups, such as AIDS and transplant patients (3,4) [19].
  • The intents of this paper are twofold: 1) to briefly review the current literature on cat scratch disease, 2) to demonstrate that cat scratch disease complicated by encephalopathy presents acutely with seizures, posturing and coma and resolves rapidly with supportive care [20].

Analytical, diagnostic and therapeutic context of Cat-Scratch Disease


  1. Use of Bartonella antigens for serologic diagnosis of cat-scratch disease at a national referral center. Dalton, M.J., Robinson, L.E., Cooper, J., Regnery, R.L., Olson, J.G., Childs, J.E. Arch. Intern. Med. (1995) [Pubmed]
  2. Application of polymerase chain reaction assay in the diagnosis of orbital granuloma complicating atypical oculoglandular cat scratch disease. Dondey, J.C., Sullivan, T.J., Robson, J.M., Gatto, J. Ophthalmology (1997) [Pubmed]
  3. 16S rRNA sequences of Bartonella bacilliformis and cat scratch disease bacillus reveal phylogenetic relationships with the alpha-2 subgroup of the class Proteobacteria. O'Connor, S.P., Dorsch, M., Steigerwalt, A.G., Brenner, D.J., Stackebrandt, E. J. Clin. Microbiol. (1991) [Pubmed]
  4. A case of cat scratch disease neuroretinitis confirmed by polymerase chain reaction. Fukushima, A., Yasuoka, M., Tsukahara, M., Ueno, H. Jpn. J. Ophthalmol. (2003) [Pubmed]
  5. Successful treatment of cat-scratch disease with ciprofloxacin. Holley, H.P. JAMA (1991) [Pubmed]
  6. Antibiotic therapy for cat-scratch disease? Bogue, C.W., Wise, J.D., Gray, G.F., Edwards, K.M. JAMA (1989) [Pubmed]
  7. Portal triad involvement in cat-scratch disease. Zinzindohoue, F., Guiard-Schmid, J.B., La Scola, B., Frottier, J., Parc, R. Lancet (1996) [Pubmed]
  8. Response of HIV-associated disseminated cat scratch disease to treatment with doxycycline. Mui, B.S., Mulligan, M.E., George, W.L. Am. J. Med. (1990) [Pubmed]
  9. Intracellular growth of Afipia felis, a putative etiologic agent of cat scratch disease. Birkness, K.A., George, V.G., White, E.H., Stephens, D.S., Quinn, F.D. Infect. Immun. (1992) [Pubmed]
  10. Azithromycin for the treatment of cat-scratch disease. Chia, J.K., Nakata, M.M., Lami, J.L., Park, S.S., Ding, J.C. Clin. Infect. Dis. (1998) [Pubmed]
  11. Rapid polymerase chain reaction-based detection of the causative agent of cat scratch disease (Bartonella henselae) in formalin-fixed, paraffin-embedded samples. Mouritsen, C.L., Litwin, C.M., Maiese, R.L., Segal, S.M., Segal, G.H. Hum. Pathol. (1997) [Pubmed]
  12. Molecular characterization and proposal of a neotype strain for Bartonella bacilliformis. Brenner, D.J., O'Connor, S.P., Hollis, D.G., Weaver, R.E., Steigerwalt, A.G. J. Clin. Microbiol. (1991) [Pubmed]
  13. Epithelioid angiomatosis in patients with AIDS. Report of seven cases and review of the literature. Szaniawski, W.K., Don, P.C., Bitterman, S.R., Schachner, J.R. J. Am. Acad. Dermatol. (1990) [Pubmed]
  14. Cat-scratch disease neuroretinitis diagnosed by a polymerase chain reaction approach. Labalette, P., Bermond, D., Dedes, V., Savage, C. Am. J. Ophthalmol. (2001) [Pubmed]
  15. Three cases of cat scratch disease diagnosed by indirect immunofluorescence antibody assay and/or polymerase chain reaction of 16S rRNA gene of Bartonella henselae. Maruyama, S., Kabeya, H., Nogami, S., Sakai, H., Suzuki, J., Suzuki, H., Sugita, H., Katsube, Y. J. Vet. Med. Sci. (2000) [Pubmed]
  16. Circulating cytokines in patients with cat scratch disease. Papadopoulos, N.G., Gourgiotis, D., Bossios, A., Fretzayas, A., Moustaki, M., Karpathios, T. Clin. Infect. Dis. (2001) [Pubmed]
  17. Development of IgA nephritis following cat scratch disease in a 13-year-old boy. Hopp, L., Eppes, S.C. Pediatr. Nephrol. (2004) [Pubmed]
  18. An ocular cat-scratch disease patient positive for cytoplasmic anti-neutrophil cytoplasmic antibody. Fukushima, H., Numaga, J., Yoshimoto, M., Kato, S., Kawashima, H. Graefes Arch. Clin. Exp. Ophthalmol. (2001) [Pubmed]
  19. An unusual presentation of cat scratch encephalitis. Chan, L., Reilly, K.M., Snyder, H.S. The Journal of emergency medicine. (1995) [Pubmed]
  20. Cat scratch encephalopathy. Silver, B.E., Bean, C.S. Delaware medical journal. (1991) [Pubmed]
  21. Diagnosis of cat scratch disease with Bartonella henselae infection in formalin-fixed paraffin-embedded tissues by two different PCR assays. Qian, X., Jin, L., Hayden, R.T., Macon, W.R., Lloyd, R.V. Diagn. Mol. Pathol. (2005) [Pubmed]
  22. Enzyme immunoassay for the diagnosis of cat-scratch disease defined by polymerase chain reaction. Giladi, M., Kletter, Y., Avidor, B., Metzkor-Cotter, E., Varon, M., Golan, Y., Weinberg, M., Riklis, I., Ephros, M., Slater, L. Clin. Infect. Dis. (2001) [Pubmed]
  23. Survey of veterinary professionals for antibodies to Bartonella henselae in Japan. Kumasaka, K., Arashima, Y., Yanai, M., Hosokawa, N., Kawano, K. Rinsho Byori (2001) [Pubmed]
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