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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Serology


Psychiatry related information on Serology

  • Heavy alcohol consumption and cigarette smoking were found to be independently associated with a statistically significant two to threefold increase in risk of HCC after adjustment for hepatitis B and C serology [6].

High impact information on Serology

  • It is concluded that human SLE serology and some associated renal changes can be reproduced solely by PBL transferred from afflicted patients, and that SCID-human-SLE mice may serve as an in vivo laboratory model for the study of human SLE [7].
  • Using a mouse cell line transformed with and expressing a single HLA DR-alpha and DR-beta chain gene, we present evidence that the product of the DR-beta chain gene carries a supertypic determinant, BR3, previously defined by serology [8].
  • Indeed, the A alpha and A beta chains of the I-A antigens appear to exhibit normal behavior by the criteria of serology and two dimensional gel analysis [9].
  • METHODS : A meta-analysis of case-control studies with age- and sex-matched controls, which provided raw data on the infection rates with H. pylori and cagA strains of H. pylori as detected by serology or polymerase chain reaction DNA, was performed [10].
  • The cost of serology makes it more attractive compared with the urea breath test [11].

Chemical compound and disease context of Serology


Biological context of Serology


Anatomical context of Serology


Associations of Serology with chemical compounds

  • Structure and serology of the native polysaccharide antigen of type Ia group B streptococcus [27].
  • Progeny virus resulting from transcript infection was phenotypically indistinguishable from the progenitor virus used to generate the original cDNA forms as judged by sucrose density gradient sedimentation, specific infectivity, plaque morphology, and serology [28].
  • We then review the diagnostic approaches to infections potentially due to the novel chlamydiae, especially focusing on the currently available PCR-based protocols, mammalian cell culture, the amoebal coculture system, and serology [29].
  • The results of this analysis suggest that the epitopes of the S. typhimurium LPS molecule that are recognized by the host are considerably more complex than has been previously indicated by classical serology [30].
  • The serology used was based on an acid glycine extract of H pylori [31].

Gene context of Serology

  • Nine of these pairs were also HLA-A and HLA-B matched by serology [32].
  • HLA-A and B antigens were typed by serology, whereas DNA based methods were used to define HLA-C gene groups, and HLA-DRB1 and DQB1 alleles [33].
  • The CTLp assay was most sensitive to HLA-A and HLA-B locus disparity detected by serology or IEF [34].
  • In most cases the target molecules were HLA-C antigens that had escaped detection by serology (e.g. Cw*1601, 1502 or 0702) [35].
  • Four other donor/recipient pairs were HLA-A,-B, and -DR identical by serology but allele mismatched at either DRB1 or DQB [36].

Analytical, diagnostic and therapeutic context of Serology

  • Archived liver and serum from six patients undergoing liver transplantation for non-A, non-B, non-C FLF with associated AA were analyzed for the presence of B19 DNA and anti-B19 serology [37].
  • Molecules secreted from these variants bear anti-GAT mu-chain and MOPC 21 L chain (as judged by serology and Southern blot studies), lack GAT binding activity and CGAT idiotype, and exhibit a "new" private idiotype (E8) [38].
  • Screening 3000 sera each from human and equine patients over the past 4 years by new enzyme immunoassays (EIAs) revealed that BDV-CICs indicate 10 times higher infection rates (up to 30% in controls, up to 100% in patients) than did previous serology [39].
  • All had gastric endoscopic ultrasonography and H pylori status assessment (histology, culture, polymerase chain reaction, and serology) [40].
  • The ultimate diagnosis is based on specific diagnostic tests which include serology, demonstration of C. burnetii in valvular material, isolation of C. burnetii from blood and tissue samples by cell-culture techniques as well as amplification and detection of the bacterial DNA by polymerase chain reaction [41].


  1. Experimental carcinoma of liver in macaque monkeys exposed to diethylnitrosamine and hepatitis B virus. Gyorkey, F., Melnick, J.L., Mirkovic, R., Cabral, G.A., Gyorkey, P., Hollinger, F.B. J. Natl. Cancer Inst. (1977) [Pubmed]
  2. Site-directed serology with synthetic peptides representing the large glycoprotein G of respiratory syncytial virus. Norrby, E., Mufson, M.A., Alexander, H., Houghten, R.A., Lerner, R.A. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  3. The course of hepatitis C virus infection after liver transplantation. Féray, C., Gigou, M., Samuel, D., Paradis, V., Wilber, J., David, M.F., Urdea, M., Reynes, M., Bréchot, C., Bismuth, H. Hepatology (1994) [Pubmed]
  4. Cat-scratch disease-associated arthropathy. Giladi, M., Maman, E., Paran, D., Bickels, J., Comaneshter, D., Avidor, B., Varon-Graidy, M., Ephros, M., Wientroub, S. Arthritis Rheum. (2005) [Pubmed]
  5. Development of spontaneous multisystem autoimmune disease and hypersensitivity to antibody-induced inflammation in Fcgamma receptor IIa-transgenic mice. Tan Sardjono, C., Mottram, P.L., van de Velde, N.C., Powell, M.S., Power, D., Slocombe, R.F., Wicks, I.P., Campbell, I.K., McKenzie, S.E., Brooks, M., Stevenson, A.W., Hogarth, P.M. Arthritis Rheum. (2005) [Pubmed]
  6. Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S. Yuan, J.M., Govindarajan, S., Arakawa, K., Yu, M.C. Cancer (2004) [Pubmed]
  7. Transfer of human systemic lupus erythematosus in severe combined immunodeficient (SCID) mice. Duchosal, M.A., McConahey, P.J., Robinson, C.A., Dixon, F.J. J. Exp. Med. (1990) [Pubmed]
  8. Serological and immunochemical analysis of the products of a single HLA DR-alpha and DR-beta chain gene expressed in a mouse cell line after DNA-mediated cotransformation reveals that the beta chain carries a known supertypic specificity. Gorski, J., Tosi, R., Strubin, M., Rabourdin-Combe, C., Mach, B. J. Exp. Med. (1985) [Pubmed]
  9. Intragenic recombination in an E beta gene for a murine Ia antigen. Plunkett, M.L., Coligan, J.E., David, C.S., Freed, J.H. J. Exp. Med. (1982) [Pubmed]
  10. Meta-analysis of the relationship between cagA seropositivity and gastric cancer. Huang, J.Q., Zheng, G.F., Sumanac, K., Irvine, E.J., Hunt, R.H. Gastroenterology (2003) [Pubmed]
  11. How should Helicobacter pylori infection be diagnosed? Mégraud, F. Gastroenterology (1997) [Pubmed]
  12. Simplified single sample 13Carbon urea breath test for Helicobacter pylori: comparison with histology, culture, and ELISA serology. Logan, R.P., Polson, R.J., Misiewicz, J.J., Rao, G., Karim, N.Q., Newell, D., Johnson, P., Wadsworth, J., Walker, M.M., Baron, J.H. Gut (1991) [Pubmed]
  13. Outcome analysis of 71 clinical intestinal transplantations. Todo, S., Reyes, J., Furukawa, H., Abu-Elmagd, K., Lee, R.G., Tzakis, A., Rao, A.S., Starzl, T.E. Ann. Surg. (1995) [Pubmed]
  14. Complex serology and immune response of mice to variant high-molecular-weight O polysaccharides isolated from Pseudomonas aeruginosa serogroup O2 strains. Hatano, K., Pier, G.B. Infect. Immun. (1998) [Pubmed]
  15. Comparison of proteins involved in pilus synthesis and mating pair stabilization from the related plasmids F and R100-1: insights into the mechanism of conjugation. Anthony, K.G., Klimke, W.A., Manchak, J., Frost, L.S. J. Bacteriol. (1999) [Pubmed]
  16. Ameboma presenting as acute urinary retention. Schattner, A., Naphtali, B., Gindin, J., Zvi, B., Becker, S. Am. J. Gastroenterol. (1989) [Pubmed]
  17. Comparative studies of the major histocompatibility complex in French Canadian and non-French Canadian Caucasians with systemic lupus erythematosus. Goldstein, R., Sengar, D.P. Arthritis Rheum. (1993) [Pubmed]
  18. The major histocompatibility complex in swine. Chardon, P., Renard, C., Vaiman, M. Immunol. Rev. (1999) [Pubmed]
  19. Zinc is an essential cofactor for recognition of the DNA binding domain of poly(ADP-ribose) polymerase by antibodies in autoimmune rheumatic and bowel diseases. Decker, P., Briand, J.P., de Murcia, G., Pero, R.W., Isenberg, D.A., Muller, S. Arthritis Rheum. (1998) [Pubmed]
  20. Serologic evidence of Chlamydia pneumoniae infection as a long-term predictor of cardiovascular death in renal transplant recipients. Haubitz, M., Votsch, K., Woywodt, A., Nashan, B., Groh, A., Haller, H., Brunkhorst, R. Transplantation (2004) [Pubmed]
  21. Alpha 1-antitrypsin levels and phenotypes and hepatitis B serology in liver cancer. Sparos, L., Tountas, Y., Chapuis-Cellier, C., Theodoropoulos, G., Trichopoulos, D. Br. J. Cancer (1984) [Pubmed]
  22. Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons. Almanzar, G., Schwaiger, S., Jenewein, B., Keller, M., Herndler-Brandstetter, D., Würzner, R., Schönitzer, D., Grubeck-Loebenstein, B. J. Virol. (2005) [Pubmed]
  23. BK virus encephalitis in an immunocompetent patient. Voltz, R., Jäger, G., Seelos, K., Fuhry, L., Hohlfeld, R. Arch. Neurol. (1996) [Pubmed]
  24. Associations of HLA-DR and HLA-DQ types with anti-GBM nephritis by sequence-specific oligonucleotide probe hybridization. Huey, B., McCormick, K., Capper, J., Ratliff, C., Colombe, B.W., Garovoy, M.R., Wilson, C.B. Kidney Int. (1993) [Pubmed]
  25. A family study of multiple mutations of alpha and delta glycophorins (glycophorins A and B). Huang, C.H., Puglia, K.V., Bigbee, W.L., Guizzo, M.L., Hoffman, M., Blumenfeld, O.O. Hum. Genet. (1988) [Pubmed]
  26. Bartonella henselae endocarditis in an immunocompetent adult. Holmes, A.H., Greenough, T.C., Balady, G.J., Regnery, R.L., Anderson, B.E., O'Keane, J.C., Fonger, J.D., McCrone, E.L. Clin. Infect. Dis. (1995) [Pubmed]
  27. Structure and serology of the native polysaccharide antigen of type Ia group B streptococcus. Jennings, H.J., Rosell, K.G., Kasper, D.L. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  28. Infectious RNA derived by transcription from cloned cDNA copies of the genomic RNA of an insect virus. Dasmahapatra, B., Dasgupta, R., Saunders, K., Selling, B., Gallagher, T., Kaesberg, P. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  29. Pathogenic potential of novel Chlamydiae and diagnostic approaches to infections due to these obligate intracellular bacteria. Corsaro, D., Greub, G. Clin. Microbiol. Rev. (2006) [Pubmed]
  30. Monoclonal antibodies demonstrate multiple epitopes on the O antigens of Salmonella typhimurium LPS. Elkins, K., Metcalf, E.S. J. Immunol. (1984) [Pubmed]
  31. Serology for Helicobacter pylori compared with symptom questionnaires in screening before direct access endoscopy. Mendall, M.A., Jazrawi, R.P., Marrero, J.M., Molineaux, N., Levi, J., Maxwell, J.D., Northfield, T.C. Gut (1995) [Pubmed]
  32. Frequent HLA class I and DP sequence mismatches in serologically (HLA-A, HLA-B, HLA-DR) and molecularly (HLA-DRB1, HLA-DQA1, HLA-DQB1) HLA-identical unrelated bone marrow transplant pairs. Santamaria, P., Reinsmoen, N.L., Lindstrom, A.L., Boyce-Jacino, M.T., Barbosa, J.J., Faras, A.J., McGlave, P.B., Rich, S.S. Blood (1994) [Pubmed]
  33. HLA-C and HLA-DQB1 compatibility in unrelated cord blood transplants. Elia, L., Arcese, W., Torello, M., Iori, A.P., Guglielmi, C., Perrone, M.P., Screnci, M., Sprovieri, T., Rapanotti, M.C., Cimino, G. Haematologica (1999) [Pubmed]
  34. Association of donor-derived host-reactive cytolytic and helper T cells with outcome following alternative donor T cell-depleted bone marrow transplantation. Keever-Taylor, C.A., Passweg, J., Kawanishi, Y., Casper, J., Flomenberg, N., Baxter-Lowe, L.A. Bone Marrow Transplant. (1997) [Pubmed]
  35. Molecular characterization of HLA-C incompatibilities in HLA-ABDR-matched unrelated bone marrow donor-recipient pairs. Sequence of two new Cw alleles (Cw*02023 and Cw*0707) and recognition by cytotoxic T lymphocytes. Grundschober, C., Rufer, N., Sanchez-Mazas, A., Madrigal, A., Jeannet, M., Roosnek, E., Tiercy, J.M. Tissue Antigens (1997) [Pubmed]
  36. Allogeneic bone marrow transplantation with matched unrelated donors for patients with hematologic malignancies using a preparative regimen of high-dose cyclophosphamide and fractionated total body irradiation. Geller, R.B., Devine, S.M., O'Toole, K., Persons, L., Keller, J., Mauer, D., Holland, H.K., Dix, S.P., Piotti, M., Redei, I., Connaghan, G., Heffner, L.T., Hillyer, C.D., Waller, E.K., Winton, E.F., Wingard, J.R. Bone Marrow Transplant. (1997) [Pubmed]
  37. Parvovirus B19 as a possible causative agent of fulminant liver failure and associated aplastic anemia. Langnas, A.N., Markin, R.S., Cattral, M.S., Naides, S.J. Hepatology (1995) [Pubmed]
  38. Immunoselection of B cell hybridomas with anti-idiotypic antisera to study the role of heavy and light chains for idiotype expression and antibody activity. Ju, S.T., Pincus, S.H., Kunar, J., Dorf, M.E. J. Immunol. (1984) [Pubmed]
  39. Borna disease virus-specific circulating immune complexes, antigenemia, and free antibodies--the key marker triplet determining infection and prevailing in severe mood disorders. Bode, L., Reckwald, P., Severus, W.E., Stoyloff, R., Ferszt, R., Dietrich, D.E., Ludwig, H. Mol. Psychiatry (2001) [Pubmed]
  40. Predictive factors for regression of gastric MALT lymphoma after anti-Helicobacter pylori treatment. Ruskoné-Fourmestraux, A., Lavergne, A., Aegerter, P.H., Megraud, F., Palazzo, L., de Mascarel, A., Molina, T., Rambaud, J.L. Gut (2001) [Pubmed]
  41. Q fever endocarditis. Stein, A., Raoult, D. Eur. Heart J. (1995) [Pubmed]
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