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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Créange, A. et al.

Créange, Chazaud, Plonquet, Sharshar, Poron, Sonnet, Raphaël, Gherardi,

IFN-beta decreases adhesion and transmigration capacities of lymphocytes in Guillain-BarrÃ© syndrome.

The adhesion capacities, transmigration capacities, and integrin expression of lymphocytes from patients with Guillain-BarrÃ© syndrome incubated with interferon-beta were studied. Interferon-beta induced a dose-dependent inhibition of lymphocyte adhesion to recombinant vascular adhesion molecule-1 (p < 0.0001) and recombinant intercellular adhesion molecule-1 (rICAM-1) (p < 0.01) without modulation of very late activation molecule-4 and lymphocyte function- associated antigen-1 expressions and a dose-dependent decrease of lymphocyte transmigration across fibronectin (p < 0.0001). Inhibition of adhesion to rICAM-1 was similar after long (18 hours) or short (5 minutes) incubation time. These results support the potential therapeutic benefit of interferon-beta in Guillain-BarrÃ© syndrome.[1]

References

IFN-beta decreases adhesion and transmigration capacities of lymphocytes in Guillain-Barré syndrome. Créange, A., Chazaud, B., Plonquet, A., Sharshar, T., Poron, F., Sonnet, C., Raphaël, J.C., Gherardi, R.K. Neurology (2001) [Pubmed]

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