Gene Review:
FN1 - fibronectin 1
Homo sapiens
Synonyms:
CIG, Cold-insoluble globulin, ED-B, FINC, FN, ...
Burnham,
Mayouf,
Ritzenthaler,
Desnick,
Youker,
Baughn,
Harris,
Dowling,
Glucksman,
Boumah,
Moss,
Birdsall,
Wygant,
Evans,
McIntyre,
Ritzenthaler,
Huang,
Roman,
Bahabri,
Eid,
de la Chapelle,
Pellegata,
Rossen,
Sewairi,
Roman,
Han,
Entman,
Kloos,
Nagaraja,
Sitaraman,
Aqeel,
Prasad,
Meyer,
Trial,
Kambouris,
Martignetti,
Sheth,
- Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors. Prasad, M.L., Pellegata, N.S., Huang, Y., Nagaraja, H.N., de la Chapelle, A., Kloos, R.T. Mod. Pathol. (2005)
- Differentially expressed genes in neurofibromatosis 1-associated neurofibromas and malignant peripheral nerve sheath tumors. Holtkamp, N., Mautner, V.F., Friedrich, R.E., Harder, A., Hartmann, C., Theallier-Janko, A., Hoffmann, K.T., von Deimling, A. Acta Neuropathol. (2004)
- Correlation of fibrosis and transforming growth factor-beta type 2 levels in the eye. Connor, T.B., Roberts, A.B., Sporn, M.B., Danielpour, D., Dart, L.L., Michels, R.G., de Bustros, S., Enger, C., Kato, H., Lansing, M. J. Clin. Invest. (1989)
- Fibronectin fragments modulate monocyte VLA-5 expression and monocyte migration. Trial, J., Baughn, R.E., Wygant, J.N., McIntyre, B.W., Birdsall, H.H., Youker, K.A., Evans, A., Entman, M.L., Rossen, R.D. J. Clin. Invest. (1999)
- Inhibition of fibronectin binding and fibronectin-mediated cell adhesion to collagen by a peptide from the second type I repeat of thrombospondin. Sipes, J.M., Guo, N., Nègre, E., Vogel, T., Krutzsch, H.C., Roberts, D.D. J. Cell Biol. (1993)
- Increased fibronectin expression in lung in the setting of chronic alcohol abuse. Burnham, E.L., Moss, M., Ritzenthaler, J.D., Roman, J. Alcohol. Clin. Exp. Res. (2007)
- Evidence that autologous idiotypic regulation of anti-arginine-glycine-aspartic acid autoantibodies may influence development and progression of syphilitic lesions in infected rabbits. Baughn, R.E., Musher, D.M. Infect. Immun. (1992)
- The preterm prediction study: patterns of cervicovaginal fetal fibronectin as predictors of spontaneous preterm delivery. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Goldenberg, R.L., Mercer, B.M., Iams, J.D., Moawad, A.H., Meis, P.J., Das, A., McNellis, D., Miodovnik, M., Menard, M.K., Caritis, S.N., Thurnau, G.R., Bottoms, S.F. Am. J. Obstet. Gynecol. (1997)
- Fibronectin staining detects micro-organisms in aged and Alzheimer's disease brain. Howard, J., Pilkington, G.J. Neuroreport (1992)
- Appearance of localized immunoreactivity for the alpha 4 integrin subunit and for fibronectin in brains from Alzheimer's, Lewy body dementia patients and aged controls. Van Gool, D., Carmeliet, G., Triau, E., Cassiman, J.J., Dom, R. Neurosci. Lett. (1994)
- The molecular structure of cell adhesion molecules. Chothia, C., Jones, E.Y. Annu. Rev. Biochem. (1997)
- A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors. Jan, Y., Matter, M., Pai, J.T., Chen, Y.L., Pilch, J., Komatsu, M., Ong, E., Fukuda, M., Ruoslahti, E. Cell (2004)
- Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome. Martignetti, J.A., Aqeel, A.A., Sewairi, W.A., Boumah, C.E., Kambouris, M., Mayouf, S.A., Sheth, K.V., Eid, W.A., Dowling, O., Harris, J., Glucksman, M.J., Bahabri, S., Meyer, B.F., Desnick, R.J. Nat. Genet. (2001)
- Integrin activation by R-ras. Zhang, Z., Vuori, K., Wang, H., Reed, J.C., Ruoslahti, E. Cell (1996)
- The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains. Hughes, J., Ward, C.J., Peral, B., Aspinwall, R., Clark, K., San Millán, J.L., Gamble, V., Harris, P.C. Nat. Genet. (1995)
- Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cells. Pöllänen, J., Saksela, O., Salonen, E.M., Andreasen, P., Nielsen, L., Danø, K., Vaheri, A. J. Cell Biol. (1987)
- Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1. Sanz-Rodríguez, F., Hidalgo, A., Teixidó, J. Blood (2001)
- Retinoic acid increases tyrosine phosphorylation of focal adhesion kinase and paxillin in MCF-7 human breast cancer cells. Zhu, W.Y., Jones, C.S., Amin, S., Matsukuma, K., Haque, M., Vuligonda, V., Chandraratna, R.A., De Luca, L.M. Cancer Res. (1999)
- Fibronectin Increases Matrix Metalloproteinase 9 Expression through Activation of c-Fos via Extracellular-regulated Kinase and Phosphatidylinositol 3-Kinase Pathways in Human Lung Carcinoma Cells. Han, S., Ritzenthaler, J.D., Sitaraman, S.V., Roman, J. J. Biol. Chem. (2006)
- Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins. Velasco, G., Cal, S., Quesada, V., Sánchez, L.M., López-Otín, C. J. Biol. Chem. (2002)
- A genetic map of nine loci on bovine chromosome 2. Beever, J.E., Da, Y., Ron, M., Lewin, H.A. Mamm. Genome (1994)
- In situ hybridization applied to Waardenburg syndrome. Wu, B.L., Milunsky, A., Wyandt, H., Hoth, C., Baldwin, C., Skare, J. Cytogenet. Cell Genet. (1993)
- Cell adhesion and migration are regulated at distinct stages of thymic T cell development: the roles of fibronectin, VLA4, and VLA5. Crisa, L., Cirulli, V., Ellisman, M.H., Ishii, J.K., Elices, M.J., Salomon, D.R. J. Exp. Med. (1996)
- T cell receptor- and beta 1 integrin-mediated signals synergize to induce tyrosine phosphorylation of focal adhesion kinase (pp125FAK) in human T cells. Maguire, J.E., Danahey, K.M., Burkly, L.C., van Seventer, G.A. J. Exp. Med. (1995)
- Cytokines increase human hemopoietic cell adhesiveness by activation of very late antigen (VLA)-4 and VLA-5 integrins. Lévesque, J.P., Leavesley, D.I., Niutta, S., Vadas, M., Simmons, P.J. J. Exp. Med. (1995)
- The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Ohh, M., Yauch, R.L., Lonergan, K.M., Whaley, J.M., Stemmer-Rachamimov, A.O., Louis, D.N., Gavin, B.J., Kley, N., Kaelin, W.G., Iliopoulos, O. Mol. Cell (1998)
- Freezing adhesion molecules in a state of high-avidity binding blocks eosinophil migration. Kuijpers, T.W., Mul, E.P., Blom, M., Kovach, N.L., Gaeta, F.C., Tollefson, V., Elices, M.J., Harlan, J.M. J. Exp. Med. (1993)
- Thrombospondin binds to monocytes-macrophages and mediates platelet-monocyte adhesion. Silverstein, R.L., Nachman, R.L. J. Clin. Invest. (1987)
- VLA-5 is expressed by mouse and human long-term repopulating hematopoietic cells and mediates adhesion to extracellular matrix protein fibronectin. van der Loo, J.C., Xiao, X., McMillin, D., Hashino, K., Kato, I., Williams, D.A. J. Clin. Invest. (1998)
- Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors. Lawler, J., Weinstein, R., Hynes, R.O. J. Cell Biol. (1988)
- Caveolin-1-dependent beta1 integrin endocytosis is a critical regulator of fibronectin turnover. Shi, F., Sottile, J. J. Cell. Sci. (2008)
- Extracellular matrix interacts with soluble CD95L: retention and enhancement of cytotoxicity. Aoki, K., Kurooka, M., Chen, J.J., Petryniak, J., Nabel, E.G., Nabel, G.J. Nat. Immunol. (2001)
- Thrombospondin-induced adhesion of human keratinocytes. Varani, J., Nickoloff, B.J., Riser, B.L., Mitra, R.S., O'Rourke, K., Dixit, V.M. J. Clin. Invest. (1988)
- Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins. Czekay, R.P., Aertgeerts, K., Curriden, S.A., Loskutoff, D.J. J. Cell Biol. (2003)
- Multiple integrins mediate cell attachment to cytotactin/tenascin. Prieto, A.L., Edelman, G.M., Crossin, K.L. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Adhesion of synchronized human hematopoietic progenitor cells to fibronectin and vascular cell adhesion molecule-1 fluctuates reversibly during cell cycle transit in ex vivo culture. Huygen, S., Giet, O., Artisien, V., Di Stefano, I., Beguin, Y., Gothot, A. Blood (2002)
- Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness. Sher, Y.P., Chou, C.C., Chou, R.H., Wu, H.M., Wayne Chang, W.S., Chen, C.H., Yang, P.C., Wu, C.W., Yu, C.L., Peck, K. Cancer Res. (2006)
- Potential involvement of kallikrein hK2 in the hydrolysis of the human seminal vesicle proteins after ejaculation. Deperthes, D., Frenette, G., Brillard-Bourdet, M., Bourgeois, L., Gauthier, F., Tremblay, R.R., Dubé, J.Y. J. Androl. (1996)
- Homophilic PECAM-1(CD31) interactions prevent endothelial cell apoptosis but do not support cell spreading or migration. Bird, I.N., Taylor, V., Newton, J.P., Spragg, J.H., Simmons, D.L., Salmon, M., Buckley, C.D. J. Cell. Sci. (1999)
- Modulation of tissue plasminogen activator-catalyzed plasminogen activation by synthetic peptides derived from the amino-terminal heparin binding domain of fibronectin. Stack, M.S., Pizzo, S.V. J. Biol. Chem. (1993)
- Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillin. Bellis, S.L., Perrotta, J.A., Curtis, M.S., Turner, C.E. Biochem. J. (1997)
- Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils. Taipale, J., Saharinen, J., Hedman, K., Keski-Oja, J. J. Histochem. Cytochem. (1996)
- Biological functions of entactin. Chung, A.E., Dong, L.J., Wu, C., Durkin, M.E. Kidney Int. (1993)
- The receptor for urokinase-type plasminogen activator regulates fibronectin matrix assembly in human skin fibroblasts. Monaghan, E., Gueorguiev, V., Wilkins-Port, C., McKeown-Longo, P.J. J. Biol. Chem. (2004)
- Localization of fibronectin matrix assembly sites on fibroblasts and endothelial cells. Christopher, R.A., Kowalczyk, A.P., McKeown-Longo, P.J. J. Cell. Sci. (1997)
- Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling. Rosenberger, G., Jantke, I., Gal, A., Kutsche, K. Hum. Mol. Genet. (2003)
- TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. Hocevar, B.A., Brown, T.L., Howe, P.H. EMBO J. (1999)
- Fibronectin matrix regulates activation of RHO and CDC42 GTPases and cell cycle progression. Bourdoulous, S., Orend, G., MacKenna, D.A., Pasqualini, R., Ruoslahti, E. J. Cell Biol. (1998)
- Fibronectin upregulates gelatinase B (MMP-9) and induces coordinated expression of gelatinase A (MMP-2) and its activator MT1-MMP (MMP-14) by human T lymphocyte cell lines. A process repressed through RAS/MAP kinase signaling pathways. Esparza, J., Vilardell, C., Calvo, J., Juan, M., Vives, J., Urbano-Márquez, A., Yagüe, J., Cid, M.C. Blood (1999)
- Conformational regulation of the fibronectin binding and alpha 3beta 1 integrin-mediated adhesive activities of thrombospondin-1. Rodrigues, R.G., Guo , N., Zhou, L., Sipes, J.M., Williams, S.B., Templeton, N.S., Gralnick, H.R., Roberts, D.D. J. Biol. Chem. (2001)
- Thrombospondin-platelet interactions. Role of divalent cations, wall shear rate, and platelet membrane glycoproteins. Agbanyo, F.R., Sixma, J.J., de Groot, P.G., Languino, L.R., Plow, E.F. J. Clin. Invest. (1993)
- Association of MMP-2 activation potential with metastatic progression in human breast cancer cell lines independent of MMP-2 production. Azzam, H.S., Arand, G., Lippman, M.E., Thompson, E.W. J. Natl. Cancer Inst. (1993)
- Fibronectin and vitronectin regulate the organization of their respective Arg-Gly-Asp adhesion receptors in cultured human endothelial cells. Dejana, E., Colella, S., Conforti, G., Abbadini, M., Gaboli, M., Marchisio, P.C. J. Cell Biol. (1988)
- Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling. Aguirre Ghiso, J.A., Kovalski, K., Ossowski, L. J. Cell Biol. (1999)
- Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I. Jones, J.I., Gockerman, A., Busby, W.H., Camacho-Hubner, C., Clemmons, D.R. J. Cell Biol. (1993)
- Angioinhibitory action of NK4 involves impaired extracellular assembly of fibronectin mediated by perlecan-NK4 association. Sakai, K., Nakamura, T., Matsumoto, K., Nakamura, T. J. Biol. Chem. (2009)
- Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering. Rüegg, C., Postigo, A.A., Sikorski, E.E., Butcher, E.C., Pytela, R., Erle, D.J. J. Cell Biol. (1992)