Quantification of TECTA and DFNA5 expression in the developing mouse cochlea.
TECTA and DFNA5 are the mouse orthologues of the human deafness- associated genes TECTA and DFNA5. To determine how expression of these genes is regulated during development, relative mRNA abundance was examined in mice by non-radioactive RT-PCR. TECTA mRNA was detected on embryonic day 15 ( E15), increased to its highest level on postnatal day 3 (P3) and then dramatically decreased by P15. Low levels persisted (adulthood, P45 to 67) with mean mRNA abundance after P15 less than 25% of P3 levels. DFNA5 mRNA expression was constant throughout these time points. These results imply that TECTA is transcribed at a particularly high level during tectorial membrane morphogenesis. In contrast, DFNA5 is present in both the developing and mature cochlea.[1]References
- Quantification of TECTA and DFNA5 expression in the developing mouse cochlea. Maeda, Y., Fukushima, K., Kasai, N., Maeta, M., Nishizaki, K. Neuroreport (2001) [Pubmed]
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