Disease relevance of Tectorial Membrane

• Thyroid hormone-deficient period prior to the onset of hearing is associated with reduced levels of beta-tectorin protein in the tectorial membrane: implication for hearing loss [1].

High impact information on Tectorial Membrane

• In the cochlea, otoancorin is detected at two attachment zones of the tectorial membrane, a permanent one along the top of the spiral limbus and a transient one on the surface of the developing greater epithelial ridge [2].
• Finally, this study revealed a maturation process of the tectorial membrane, as evidenced by the progressive organization of otogelin labeling into thick and spaced radial fiber-like structures [3].
• It is shown experimentally that the motion of the tectorial membrane is resonant at a frequency of 0.5 octave (oct) below the resonant frequency of the basilar membrane and polarized parallel to the reticular lamina [4].
• This suggests that this gap junction protein of served patterns of connexin 26 distribution is important for the differentiation and development of these structures (e.g., the role of the inner sulcus cells in producing the tectorial membrane) [5].
• Distortion product otoacoustic emissions (DPOAE) were recorded from wild-type mice and mutant Tecta(deltaENT/deltaENT) mice with detached tectorial membranes (TM) under combined ketamine/xylaxine anesthesia [6].

Biological context of Tectorial Membrane

• These results imply that TECTA is transcribed at a particularly high level during tectorial membrane morphogenesis [7].

Anatomical context of Tectorial Membrane

• Pilocarpine-induced changes in the saccharide composition of the tectorial membrane and interdental cells of the organ of Corti: a study with gold-labeled lectins [8].
• Prior to the onset of hearing (P8), NHERF-1 immunolabeling was prominently polarized to the apical membrane of cells lining the endolymphatic compartment, including the stereocilia and cuticular plates of the inner and outer hair cells, marginal cells of the stria vascularis, Reissner's epithelia, and tectorial membrane [9].
• The findings suggest presence of the terminal disaccharides GalNAc alpha 1,3Gal in tectorial membrane and Gal beta 1,3GalNAc in vestibular membranes [10].
• Glutaminase, on the other hand, had its highest activity in synaptic zones, about a third of that activity in the organ of Corti non-synaptic zones, and a barely detectable activity in Reissner's and tectorial membranes, and stria vascularis [11].
• Secretion of a new basal layer of tectorial membrane following gentamicin-induced hair cell loss [12].

Associations of Tectorial Membrane with chemical compounds

• The concentration of gold particles on the limbal tectorial membrane in pilocarpine-treated animals was higher than in control animals for some lectins (RCA, PSA, UEA) but lower for others (WGA, SBA, PHA-E, Succ-WGA) [8].
• Carboplatin treatment also resulted in the restructuring of the tectorial membrane overlying the limbus [13].
• Tectorial membranes were extracted with a 4 M guanidine--HCl solvent, and proteoglycans isolated after ethanol precipitation and collagenase treatment [14].
• The specimens were destabilized by cutting the transverse ligament on both sides of the odontoid and the tectorial membrane between C1 and C2 [15].
• Localization of anionic sulfate groups in the tectorial membrane [16].

Gene context of Tectorial Membrane

• The expression patterns suggest essential roles for Col11a1 and Col11a2 in the basilar or tectorial membranes [17].
• The greater epithelial ridge appeared to be the main, if not only, source of mRNA encoding Col11a1 and Col11a2 in the tectorial membrane [17].
• These results further support the involvement of TECTA mutations in autosomal dominant hearing impairment, and suggest that vicinal cysteines are involved in tectorial membrane matrix assembly [18].
• The most prominent structural deficit in Pax8-/- animals in which T(4) substitution was started at P8 or later was an abnormally thick tectorial membrane [19].
• In contrast, in the tectorial membrane, otogelin should be a long-lasting protein since both the otogelin gene and protein were almost undetectable in adult cochlear cells [20].

Analytical, diagnostic and therapeutic context of Tectorial Membrane

• The effects of the enzymes collagenase, pepsin, chondroitinase ABC and keratanase on the polypeptide composition of the mammalian tectorial membrane have been analysed using one dimensional SDS-polyacrylamide gel electrophoresis (SDS-PAGE) [21].

References