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MeSH Review

Tectorial Membrane

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Disease relevance of Tectorial Membrane


High impact information on Tectorial Membrane

  • In the cochlea, otoancorin is detected at two attachment zones of the tectorial membrane, a permanent one along the top of the spiral limbus and a transient one on the surface of the developing greater epithelial ridge [2].
  • Finally, this study revealed a maturation process of the tectorial membrane, as evidenced by the progressive organization of otogelin labeling into thick and spaced radial fiber-like structures [3].
  • It is shown experimentally that the motion of the tectorial membrane is resonant at a frequency of 0.5 octave (oct) below the resonant frequency of the basilar membrane and polarized parallel to the reticular lamina [4].
  • This suggests that this gap junction protein of served patterns of connexin 26 distribution is important for the differentiation and development of these structures (e.g., the role of the inner sulcus cells in producing the tectorial membrane) [5].
  • Distortion product otoacoustic emissions (DPOAE) were recorded from wild-type mice and mutant Tecta(deltaENT/deltaENT) mice with detached tectorial membranes (TM) under combined ketamine/xylaxine anesthesia [6].

Biological context of Tectorial Membrane


Anatomical context of Tectorial Membrane


Associations of Tectorial Membrane with chemical compounds


Gene context of Tectorial Membrane


Analytical, diagnostic and therapeutic context of Tectorial Membrane

  • The effects of the enzymes collagenase, pepsin, chondroitinase ABC and keratanase on the polypeptide composition of the mammalian tectorial membrane have been analysed using one dimensional SDS-polyacrylamide gel electrophoresis (SDS-PAGE) [21].


  1. Thyroid hormone-deficient period prior to the onset of hearing is associated with reduced levels of beta-tectorin protein in the tectorial membrane: implication for hearing loss. Knipper, M., Richardson, G., Mack, A., Müller, M., Goodyear, R., Limberger, A., Rohbock, K., Köpschall, I., Zenner, H.P., Zimmermann, U. J. Biol. Chem. (2001) [Pubmed]
  2. Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22. Zwaenepoel, I., Mustapha, M., Leibovici, M., Verpy, E., Goodyear, R., Liu, X.Z., Nouaille, S., Nance, W.E., Kanaan, M., Avraham, K.B., Tekaia, F., Loiselet, J., Lathrop, M., Richardson, G., Petit, C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Otogelin: a glycoprotein specific to the acellular membranes of the inner ear. Cohen-Salmon, M., El-Amraoui, A., Leibovici, M., Petit, C. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. Resonant tectorial membrane motion in the inner ear: its crucial role in frequency tuning. Gummer, A.W., Hemmert, W., Zenner, H.P. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. Immunolocalization of connexin 26 in the developing mouse cochlea. Frenz, C.M., Van De Water, T.R. Brain Res. Brain Res. Rev. (2000) [Pubmed]
  6. Role of the tectorial membrane revealed by otoacoustic emissions recorded from wild-type and transgenic Tecta(deltaENT/deltaENT) mice. Lukashkin, A.N., Lukashkina, V.A., Legan, P.K., Richardson, G.P., Russell, I.J. J. Neurophysiol. (2004) [Pubmed]
  7. Quantification of TECTA and DFNA5 expression in the developing mouse cochlea. Maeda, Y., Fukushima, K., Kasai, N., Maeta, M., Nishizaki, K. Neuroreport (2001) [Pubmed]
  8. Pilocarpine-induced changes in the saccharide composition of the tectorial membrane and interdental cells of the organ of Corti: a study with gold-labeled lectins. Rubio, M.E., Rueda, J., Prieto, J.J., Merchán, J.A. J. Histochem. Cytochem. (1994) [Pubmed]
  9. Postnatal developmental expression of the PDZ scaffolds Na+ -H+ exchanger regulatory factors 1 and 2 in the rat cochlea. Kanjhan, R., Hryciw, D.H., Yun, C.C., Bellingham, M.C., Poronnik, P. Cell Tissue Res. (2006) [Pubmed]
  10. Histochemical analysis of glycoconjugates in gelatinous membranes of the gerbil's inner ear. Sugiyama, S., Spicer, S.S., Munyer, P.D., Schulte, B.A. Hear. Res. (1991) [Pubmed]
  11. Quantitative distributions of aspartate aminotransferase and glutaminase activities in the rat cochlea. Wiet, G.J., Godfrey, D.A., Ross, C.D., Dunn, J.D. Hear. Res. (1986) [Pubmed]
  12. Secretion of a new basal layer of tectorial membrane following gentamicin-induced hair cell loss. Epstein, J.E., Cotanche, D.A. Hear. Res. (1995) [Pubmed]
  13. Ultrastructural changes in the spiral limbus associated with carboplatin-induced ablation of inner hair cells. Spicer, S.S., Salvi, R.J., Schulte, B.A. Cell Tissue Res. (2000) [Pubmed]
  14. Uronic acid-containing glycosaminoglycans and keratan sulfate are present in the tectorial membrane of the inner ear: functional implications. Thalmann, I., Machiki, K., Calabro, A., Hascall, V.C., Thalmann, R. Arch. Biochem. Biophys. (1993) [Pubmed]
  15. Biomechanical study of atlantoaxial arthrodesis: transarticular screw fixation versus modified Brooks posterior wiring. Mitchell, T.C., Sadasivan, K.K., Ogden, A.L., Mayeux, R.H., Mukherjee, D.P., Albright, J.A. Journal of orthopaedic trauma. (1999) [Pubmed]
  16. Localization of anionic sulfate groups in the tectorial membrane. Prieto, J.J., Rubio, M.E., Merchan, J.A. Hear. Res. (1990) [Pubmed]
  17. Col11a1 and Col11a2 mRNA expression in the developing mouse cochlea: implications for the correlation of hearing loss phenotype with mutant type XI collagen genotype. Shpargel, K.B., Makishima, T., Griffith, A.J. Acta Otolaryngol. (2004) [Pubmed]
  18. Mutation in the zonadhesin-like domain of alpha-tectorin associated with autosomal dominant non-syndromic hearing loss. Alloisio, N., Morlé, L., Bozon, M., Godet, J., Verhoeven, K., Van Camp, G., Plauchu, H., Muller, P., Collet, L., Lina-Granade, G. Eur. J. Hum. Genet. (1999) [Pubmed]
  19. Hearing loss in athyroid pax8 knockout mice and effects of thyroxine substitution. Christ, S., Biebel, U.W., Hoidis, S., Friedrichsen, S., Bauer, K., Smolders, J.W. Audiol. Neurootol. (2004) [Pubmed]
  20. Spatiotemporal expression of otogelin in the developing and adult mouse inner ear. El-Amraoui, A., Cohen-Salmon, M., Petit, C., Simmler, M.C. Hear. Res. (2001) [Pubmed]
  21. Polypeptide composition of the mammalian tectorial membrane. Richardson, G.P., Russell, I.J., Duance, V.C., Bailey, A.J. Hear. Res. (1987) [Pubmed]
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