Lnk adaptor: novel negative regulator of B cell lymphopoiesis.
Originally thought to have the functions now ascribed to the linker for activation of T cells protein ( LAT), Lnk is coming into its own as an adaptor protein that mediates signaling through several receptor pathways. An essential role for Lnk in B cell development and maturation was recently uncovered by Perlmutter and colleagues. Rudd discusses the role of Lnk in B cells and hypothesizes a mechanism whereby Lnk, and its closely related protein family members, the adaptor molecules containing pleckstrin homology (PH) and Src-homology 2 (SH2) domains ( APS), and Src-homology 2-B protein (SH2-B), may mediate signal promotion or attenuation.[1]References
- Lnk adaptor: novel negative regulator of B cell lymphopoiesis. Rudd, C.E. Sci. STKE (2001) [Pubmed]
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