Gene Review:
SH2B1 - SH2B adaptor protein 1
Homo sapiens
Synonyms:
FLJ30542, KIAA1299, PSM, Pro-rich, PH and SH2 domain-containing signaling mediator, SH2 domain-containing protein 1B, ...
- Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain. Nelms, K., O'Neill, T.J., Li, S., Hubbard, S.R., Gustafson, T.A., Paul, W.E. Mamm. Genome (1999)
- Differential role of SH2-B and APS in regulating energy and glucose homeostasis. Li, M., Ren, D., Iseki, M., Takaki, S., Rui, L. Endocrinology (2006)
- Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. Ren, D., Zhou, Y., Morris, D., Li, M., Li, Z., Rui, L. J. Clin. Invest. (2007)
- Identification and characterization of novel substrates of Trk receptors in developing neurons. Qian, X., Riccio, A., Zhang, Y., Ginty, D.D. Neuron (1998)
- Kinase activation through dimerization by human SH2-B. Nishi, M., Werner, E.D., Oh, B.C., Frantz, J.D., Dhe-Paganon, S., Hansen, L., Lee, J., Shoelson, S.E. Mol. Cell. Biol. (2005)
- Identification of SH2B1β as a focal adhesion protein that regulates focal adhesion size and number. Lanning, N.J., Su, H.W., Argetsinger, L.S., Carter-Su, C. J. Cell. Sci. (2011)
- Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling. Li, M., Li, Z., Morris, D.L., Rui, L. Endocrinology (2007)
- Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling. Rui, L., Mathews, L.S., Hotta, K., Gustafson, T.A., Carter-Su, C. Mol. Cell. Biol. (1997)
- SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin. Duan, C., Li, M., Rui, L. J. Biol. Chem. (2004)
- SH2-B and SIRP: JAK2 binding proteins that modulate the actions of growth hormone. Carter-Su, C., Rui, L., Stofega, M.R. Recent Prog. Horm. Res. (2000)
- Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation. Kong, M., Wang, C.S., Donoghue, D.J. J. Biol. Chem. (2002)
- SH2-B is required for both male and female reproduction. Ohtsuka, S., Takaki, S., Iseki, M., Miyoshi, K., Nakagata, N., Kataoka, Y., Yoshida, N., Takatsu, K., Yoshimura, A. Mol. Cell. Biol. (2002)
- Lnk adaptor: novel negative regulator of B cell lymphopoiesis. Rudd, C.E. Sci. STKE (2001)
- Association of SH2-B to phosphorylated tyrosine residues in the activation loop of TrkB. Suzuki, K., Mizutani, M., Hitomi, Y., Kizaki, T., Ohno, H., Ishida, H., Haga, S., Koizumi, S. Res. Commun. Mol. Pathol. Pharmacol. (2002)
- Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta. Kurzer, J.H., Argetsinger, L.S., Zhou, Y.J., Kouadio, J.L., O'Shea, J.J., Carter-Su, C. Mol. Cell. Biol. (2004)
- Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS. Hu, J., Hubbard, S.R. J. Mol. Biol. (2006)
- SH2-B is a positive regulator of nerve growth factor-mediated activation of the Akt/Forkhead pathway in PC12 cells. Wang, X., Chen, L., Maures, T.J., Herrington, J., Carter-Su, C. J. Biol. Chem. (2004)
- Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbeta. Rui, L., Gunter, D.R., Herrington, J., Carter-Su, C. Mol. Cell. Biol. (2000)
- Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loop. Koch, A., Mancini, A., Stefan, M., Niedenthal, R., Niemann, H., Tamura, T. FEBS Lett. (2000)
- SH2-B and APS are multimeric adapters that augment TrkA signaling. Qian, X., Ginty, D.D. Mol. Cell. Biol. (2001)
- Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins. Hu, J., Hubbard, S.R. J. Biol. Chem. (2005)
- Another piece in the molecular puzzle of obesity. Senior, K. Drug Discov. Today (2005)