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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Iridoids with anti-inflammatory activity from Vitex peduncularis.

A new iridoid, pedunculariside, together with the known iridoid agnuside were isolated from the butanol extract of Vitex peduncularis stem bark. Both pedunculariside and agnuside showed preferential inhibition of COX-2, with IC50 values of 0.15 +/- 0.21 mg/ml and 0.026 +/- 0.015 mg/ml respectively, while having only small inhibitory effects on COX-1. Both compounds did not exhibit cytotoxicity against vero cells.[1]


  1. Iridoids with anti-inflammatory activity from Vitex peduncularis. Suksamrarn, A., Kumpun, S., Kirtikara, K., Yingyongnarongkul, B., Suksamrarn, S. Planta Med. (2002) [Pubmed]
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