The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Fulvoplumierin     methyl(7E)-7-[(E)-but-2- enylidene]-5-oxo...

Synonyms: AC1NQYLV, Plumiera rubra, CHEMBL445545, NSC-609064, NSC-661970, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Iridoid


Psychiatry related information on Iridoid


High impact information on Iridoid

  • Prominent neurite outgrowth induced by genipin, a plant-derived iridoid, was substantially inhibited by addition of NG-nitro-L-arginine methyl ester (L-NAME), a nitric oxide (NO) synthase (NOS) inhibitor, and carboxy-PTIO, an NO scavenger, in PC12h cells [7].
  • We therefore investigated the mode of action of 8-O-E-p-methoxycinnamoyl-harpagide (8-MCA-Harp), the most potent neuroprotective iridoid, and its aglycone, harpagide (Harp) using primary cultures of rat cortical cells in vitro [8].
  • Resolution of an iridoid synthon, gastrolactol, by means of dynamic acetylation and lipase-catalyzed alcoholysis [9].
  • A new unusual iridoid with inhibition of activator protein-1 (AP-1) from the leaves of Morinda citrifolia L [10].
  • Some regio- and stereoselective heterogeneous catalytic hydrogenations of double bonds in iridoid aglucones were discussed [9].

Chemical compound and disease context of Iridoid


Biological context of Iridoid

  • We suggest that the bitter taste of iridoid glycosides deters feeding by S. exigua, whereas the hydrolysis products formed after tissue damage following fungal infection mediate pathogen resistance [12].
  • We also tested whether there was a trade-off between growth (biomass) and defense (levels of iridoid glycosides) [13].
  • In this study, we investigated how neighbors (i.e., competitors) altered resistance phenotypes, namely plant size and levels of secondary compounds (iridoid glycosides), of individual plants and specifically tested whether neighbor identity mattered [13].
  • Effect of iridoid glycoside content on oviposition host plant choice and parasitism in a specialist herbivore [14].
  • However, for the three genotypes used in the present study, differences in resistance were not related to their constitutive or induced levels of iridoid glycosides, suggesting that additional resistance mechanisms are important in this host-pathogen system [15].

Anatomical context of Iridoid


Associations of Iridoid with other chemical compounds


Gene context of Iridoid


Analytical, diagnostic and therapeutic context of Iridoid

  • Seven iridoid glycosides could be separated with use of MEKC under basic conditions [30].
  • An isocratic HPLC system is described which allows the separation of the iridoid and indole precursors of terpenoid indole alkaloids, which are present in a single crude extract [31].
  • High-performance liquid chromatography of iridoid and secoiridoid glucosides [32].
  • Studies on monoterpene glucosides and related natural products. XXXI. Gas chromatography and gas chromatography-mass spectrometry of iridoid and secoiridoid glucosides [28].
  • Oral administration of picroliv (25 mg/kg/day for 15 days), a standardised iridoid glycoside fraction of Picrorhiza kurroa, 6 weeks after aflatoxin B1 toxication, significantly prevented the biochemical changes induced in liver and serum of aflatoxin B1 treated rats [33].


  1. Antiviral activity of seven iridoids, three saikosaponins and one phenylpropanoid glycoside extracted from Bupleurum rigidum and Scrophularia scorodonia. Bermejo, P., Abad, M.J., Díaz, A.M., Fernández, L., Santos, J.D., Sanchez, S., Villaescusa, L., Carrasco, L., Irurzun, A. Planta Med. (2002) [Pubmed]
  2. Choleretic effects of alpha-iridodiol on experimentally induced intrahepatic cholestasis. Mizoguchi, Y., Sakagami, C., Ichikawa, Y., Kobayashi, K. Planta Med. (1992) [Pubmed]
  3. New insight into the inhibition of the inflammatory response to experimental delayed-type hypersensitivity reactions in mice by scropolioside A. Bas, E., Recio, M.C., Máñez, S., Giner, R.M., Escandell, J.M., López-Ginés, C., Ríos, J.L. Eur. J. Pharmacol. (2007) [Pubmed]
  4. Structural considerations on the iridoids as anti-inflammatory agents. Recio, M.C., Giner, R.M., Máñez, S., Ríos, J.L. Planta Med. (1994) [Pubmed]
  5. Catalpol protects dopaminergic neurons from LPS-induced neurotoxicity in mesencephalic neuron-glia cultures. Tian, Y.Y., An, L.J., Jiang, L., Duan, Y.L., Chen, J., Jiang, B. Life Sci. (2006) [Pubmed]
  6. 8-O-acetylharpagide is a nonsteroidal ecdysteroid agonist. Elbrecht, A., Chen, Y., Jurgens, T., Hensens, O.D., Zink, D.L., Beck, H.T., Balick, M.J., Borris, R. Insect Biochem. Mol. Biol. (1996) [Pubmed]
  7. Activation of the mitogen-activated protein kinase cascade through nitric oxide synthesis as a mechanism of neuritogenic effect of genipin in PC12h cells. Yamazaki, M., Chiba, K., Mohri, T., Hatanaka, H. J. Neurochem. (2001) [Pubmed]
  8. Iridoids from Scrophularia buergeriana attenuate glutamate-induced neurotoxicity in rat cortical cultures. Kim, S.R., Koo, K.A., Sung, S.H., Ma, C.J., Yoon, J.S., Kim, Y.C. J. Neurosci. Res. (2003) [Pubmed]
  9. Resolution of an iridoid synthon, gastrolactol, by means of dynamic acetylation and lipase-catalyzed alcoholysis. Santangelo, E.M., Rotticci, D., Liblikas, I., Norin, T., Unelius, C.R. J. Org. Chem. (2001) [Pubmed]
  10. A new unusual iridoid with inhibition of activator protein-1 (AP-1) from the leaves of Morinda citrifolia L. Sang, S., He, K., Liu, G., Zhu, N., Cheng, X., Wang, M., Zheng, Q., Dong, Z., Ghai, G., Rosen, R.T., Ho, C.T. Org. Lett. (2001) [Pubmed]
  11. The commercial harvest of devil's claw (Harpagophytum spp.) in southern Africa: the devil's in the details. Stewart, K.M., Cole, D. Journal of ethnopharmacology. (2005) [Pubmed]
  12. Plant chemical defense against herbivores and pathogens: generalized defense or trade-offs? Biere, A., Marak, H.B., van Damme, J.M. Oecologia (2004) [Pubmed]
  13. Neighbor species differentially alter resistance phenotypes in Plantago. Barton, K.E., Bowers, M.D. Oecologia (2006) [Pubmed]
  14. Effect of iridoid glycoside content on oviposition host plant choice and parasitism in a specialist herbivore. Nieminen, M., Suomi, J., Van Nouhuys, S., Sauri, P., Riekkola, M.L. J. Chem. Ecol. (2003) [Pubmed]
  15. Systemic, genotype-specific induction of two herbivore-deterrent iridoid glycosides in Plantago lanceolata L. in response to fungal infection by Diaporthe adunca (Rob.) Niessel. Marak, H.B., Biere, A., Van Damme, J.M. J. Chem. Ecol. (2002) [Pubmed]
  16. Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor. Hamdi, H.K., Castellon, R. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  17. Inhibitory effects of a new iridoid, patridoid II and its isomers, on nitric oxide and TNF-alpha production in cultured murine macrophages. Ju, H.K., Moon, T.C., Lee, E., Baek, S.H., An, R.B., Bae, K., Son, K.H., Kim, H.P., Kang, S.S., Lee, S.H., Son, J.K., Chang, H.W. Planta Med. (2003) [Pubmed]
  18. Picroliv, the iridoid glycoside fraction of Picrorhiza kurroa, selectively augments human T cell response to mycobacterial protein antigens. Sinha, S., Mehrotra, J., Bala, L., Jaiswal, A.K., Dhawan, B.N. Immunopharmacology and immunotoxicology. (1998) [Pubmed]
  19. Modified iridoid glycosides as anti-implantation agents: inhibition of cell adhesion as an approach for developing pregnancy interceptive agents. Misra, A.P., Mathad, V.T., Raj, K., Bhaduri, A.P., Tiwari, R., Srivastava, A., Mehrotra, P.K. Bioorg. Med. Chem. (2001) [Pubmed]
  20. The iridoid glucoside secologanin is derived from the novel triose phosphate/pyruvate pathway in a Catharanthus roseus cell culture. Contin, A., van der Heijden, R., Lefeber, A.W., Verpoorte, R. FEBS Lett. (1998) [Pubmed]
  21. Senburiside II, a New Iridoid Glucoside from Swertia japonica. Ikeshiro, Y., Tomita, Y. Planta Med. (1987) [Pubmed]
  22. Iridoid Glucosides from Penstemon ovatus. König, M., Seifert, K. Planta Med. (1995) [Pubmed]
  23. Differences in neuritogenic response to nitric oxide in PC12 and PC12h cells. Yamazaki, M., Chiba, K., Mohri, T. Neurosci. Lett. (2006) [Pubmed]
  24. Geniposide activates GSH S-transferase by the induction of GST M1 and GST M2 subunits involving the transcription and phosphorylation of MEK-1 signaling in rat hepatocytes. Kuo, W.H., Chou, F.P., Young, S.C., Chang, Y.C., Wang, C.J. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  25. Cyclic GMP-dependent neurite outgrowth by genipin and nerve growth factor in PC12h cells. Yamazaki, M., Chiba, K., Mohri, T., Hatanaka, H. Eur. J. Pharmacol. (2004) [Pubmed]
  26. Effects of iridoid total glycoside from Cornus officinalis on prevention of glomerular overexpression of transforming growth factor beta 1 and matrixes in an experimental diabetes model. Xu, H.Q., Hao, H.P. Biol. Pharm. Bull. (2004) [Pubmed]
  27. New and known iridoid- and phenylethanoid glycosides from Harpagophytum procumbens and their in vitro inhibition of human leukocyte elastase. Boje, K., Lechtenberg, M., Nahrstedt, A. Planta Med. (2003) [Pubmed]
  28. Studies on monoterpene glucosides and related natural products. XXXI. Gas chromatography and gas chromatography-mass spectrometry of iridoid and secoiridoid glucosides. Inouye, H., Uobe, K., Hirai, M., Masada, Y., Hashimoto, K. J. Chromatogr. (1976) [Pubmed]
  29. Fast HPLC for quality control of Harpagophytum procumbens by using a monolithic silica column: method transfer from conventional particle-based silica column. Schmidt, A.H. Journal of chromatography. A. (2005) [Pubmed]
  30. Determination of iridoid glycosides by micellar electrokinetic capillary chromatography-mass spectrometry with use of the partial filling technique. Suomi, J., Wiedmer, S.K., Jussila, M., Riekkola, M.L. Electrophoresis (2001) [Pubmed]
  31. Analysis of several iridoid and indole precursors of terpenoid indole alkaloids with a single HPLC run. Dagnino, D., Schripsema, J., Verpoorte, R. Planta Med. (1996) [Pubmed]
  32. High-performance liquid chromatography of iridoid and secoiridoid glucosides. Meier, B., Osticher, O. J. Chromatogr. (1977) [Pubmed]
  33. Hepatocurative effect of picroliv and silymarin against aflatoxin B1 induced hepatotoxicity in rats. Rastogi, R., Srivastava, A.K., Srivastava, M., Rastogi, A.K. Planta Med. (2000) [Pubmed]
WikiGenes - Universities