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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity.

Fractionation of an ethyl acetate-soluble extract of the bark of Artocarpus dadah has led to the isolation of three new prenylated stilbenoid derivatives, 3-(gamma,gamma-dimethylallyl)resveratrol (1), 5-(gamma,gamma-dimethylallyl)oxyresveratrol (2), 3-(2,3-dihydroxy-3-methylbutyl)resveratrol (3), and a new benzofuran derivative, 3-(gamma,gamma-dimethylpropenyl)moracin M (4), along with six known compounds, oxyresveratrol, (+)-catechin, afzelechin-3-O-alpha-L-rhamnopyranoside, (-)-epiafzelechin, dihydromorin, and epiafzelechin-(4beta-->8)-epicatechin. From an ethyl acetate-soluble extract of the twigs of the same plant were isolated compound 4 and two new neolignan derivatives, dadahols A (5) and B (6), as well as 10 known compounds, oxyresveratrol, (+)-catechin, afzelechin-3-O-alpha-L-rhamnopyranoside, resveratrol, steppogenin, moracin M, isogemichalcone B, gemichalcone B, norartocarpetin, and engeletin. The structures of compounds 1-6 were determined using spectroscopic and chemical methods. Isolates were evaluated for their inhibitory effects against both cyclooxygenase-1 ( COX-1) and -2 ( COX-2) and in a mouse mammary organ culture assay.[1]


  1. Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity. Su, B.N., Cuendet, M., Hawthorne, M.E., Kardono, L.B., Riswan, S., Fong, H.H., Mehta, R.G., Pezzuto, J.M., Kinghorn, A.D. J. Nat. Prod. (2002) [Pubmed]
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