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Chemical Compound Review

SureCN988358     4-[2-(3,5-dihydroxyphenyl) ethenyl]benzene...

Synonyms: AG-E-96818, AC1L2JFQ, CTK4G3678, KB-188575
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Disease relevance of C10273


Psychiatry related information on C10273


High impact information on C10273


Biological context of C10273

  • Mulberroside A and oxyresveratrol showed an inhibitory effect against FeSO4/H2O2-induced lipid peroxidation in rat microsomes and a scavenging effect on 1,1-diphenyl-2-picrylhydrazyl radical [7].
  • The results suggest that the anti-inflammatory properties of oxyresveratrol might be correlated with inhibition of the iNOS expression through down-regulation of NF-kappaB binding activity and significant inhibition of COX-2 activity [7].

Anatomical context of C10273


Associations of C10273 with other chemical compounds


Gene context of C10273

  • The present study evaluated the neuroprotective effect of oxyresveratrol isolated from Smilacis chinae rhizome against Abeta (25-35)-induced neurotoxicity on cultured rat cortical neurons [11].
  • In this study, we investigated the inhibitory effect of 2-[2-(3,5-dimethoxyphenyl)vinyl]-thiophene (DMPVT), produced from the chemical modification of oxyresveratrol, on the activities of P450 1 enzymes [12].
  • Neuroprotective effect of oxyresveratrol from smilacis chinae rhizome on amyloid Beta protein (25-35)-induced neurotoxicity in cultured rat cortical neurons [11].
  • Therefore, the depigmenting effect of oxyresveratrol works through reversible inhibition of tyrosinase activity rather than suppression of the expression and synthesis of the enzyme [1].
  • Oxyresveratrol as the potent inhibitor on dopa oxidase activity of mushroom tyrosinase [13].

Analytical, diagnostic and therapeutic context of C10273


  1. Oxyresveratrol and hydroxystilbene compounds. Inhibitory effect on tyrosinase and mechanism of action. Kim, Y.M., Yun, J., Lee, C.K., Lee, H., Min, K.R., Kim, Y. J. Biol. Chem. (2002) [Pubmed]
  2. Oxyresveratrol (trans-2,3',4,5'-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. Andrabi, S.A., Spina, M.G., Lorenz, P., Ebmeyer, U., Wolf, G., Horn, T.F. Brain Res. (2004) [Pubmed]
  3. Blood-brain barrier permeability to the neuroprotectant oxyresveratrol. Breuer, C., Wolf, G., Andrabi, S.A., Lorenz, P., Horn, T.F. Neurosci. Lett. (2006) [Pubmed]
  4. Learning-memory deficit with aging in APP transgenic mice of Alzheimer's disease and intervention by using tetrahydroxystilbene glucoside. Zhang, L., Xing, Y., Ye, C.F., Ai, H.X., Wei, H.F., Li, L. Behav. Brain Res. (2006) [Pubmed]
  5. Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes. Piver, B., Fer, M., Vitrac, X., Merillon, J.M., Dreano, Y., Berthou, F., Lucas, D. Biochem. Pharmacol. (2004) [Pubmed]
  6. Oxyresveratrol dampens neuroimmune responses in vivo: a selective effect on TNF-{alpha}. Mouihate, A., Horn, T.F., Pittman, Q.J. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006) [Pubmed]
  7. In-vitro and in-vivo anti-inflammatory effect of oxyresveratrol from Morus alba L. Chung, K.O., Kim, B.Y., Lee, M.H., Kim, Y.R., Chung, H.Y., Park, J.H., Moon, J.O. J. Pharm. Pharmacol. (2003) [Pubmed]
  8. Phenolics with antiviral activity from Millettia erythrocalyx and Artocarpus lakoocha. Likhitwitayawuid, K., Sritularak, B., Benchanak, K., Lipipun, V., Mathew, J., Schinazi, R.F. Nat. Prod. Res. (2005) [Pubmed]
  9. A Novel Stilbene Glucoside, Oxyresveratrol 3' -O-beta-Glucopyranoside, from the Root Bark of Morus alba. Qiu, F., Komatsu, K., Kawasaki, K., Saito, K., Yao, X., Kano, Y. Planta Med. (1996) [Pubmed]
  10. Hepatoprotective and free radical scavenging activities of prenylflavonoids, coumarin, and stilbene from Morus alba. Oh, H., Ko, E.K., Jun, J.Y., Oh, M.H., Park, S.U., Kang, K.H., Lee, H.S., Kim, Y.C. Planta Med. (2002) [Pubmed]
  11. Neuroprotective effect of oxyresveratrol from smilacis chinae rhizome on amyloid Beta protein (25-35)-induced neurotoxicity in cultured rat cortical neurons. Ban, J.Y., Jeon, S.Y., Nguyen, T.T., Bae, K., Song, K.S., Seonga, Y.H. Biol. Pharm. Bull. (2006) [Pubmed]
  12. Potent inhibition of human cytochrome P450 1 enzymes by dimethoxyphenylvinyl thiophene. Lee, S.K., Kim, Y., Kim, M.Y., Kim, S., Chun, Y.J. Arch. Pharm. Res. (2004) [Pubmed]
  13. Oxyresveratrol as the potent inhibitor on dopa oxidase activity of mushroom tyrosinase. Shin, N.H., Ryu, S.Y., Choi, E.J., Kang, S.H., Chang, I.M., Min, K.R., Kim, Y. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
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