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Benquan, W. et al.

Benquan, Yingchun, Kouxing, Tiantuo, Jiaxing, Shuqing,

Staphylococcus heterogeneously resistant to vancomycin in China and antimicrobial activities of imipenem and vancomycin in combination against it.

Of 115 methicillin-resistant Staphylococcus strains collected from sputum specimens, 34 strains reduced susceptibility to vancomycin, 9 of which emerged as heterogeneous vancomycin-resistant strains (hetero-VRS), with various degrees of vancomycin resistance at a frequency of 10(-6) or higher. Seventy-six percent (19 of 25) of non-hetero-VRS and 100% (9 of 9) of hetero-VRS were susceptible to synergistic treatment with vancomycin and imipenem. Clinical clearance between 9 hetero-VRS and 25 non-hetero-VRS had an obvious statistical significance (P = 0.001). The hetero-VRS may play an important role in vancomycin therapy failure.[1]

References

Staphylococcus heterogeneously resistant to vancomycin in China and antimicrobial activities of imipenem and vancomycin in combination against it. Benquan, W., Yingchun, T., Kouxing, Z., Tiantuo, Z., Jiaxing, Z., Shuqing, T. J. Clin. Microbiol. (2002) [Pubmed]

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