- X-linked mental retardation with seizures and carrier manifestations is caused by a mutation in the creatine-transporter gene (SLC6A8) located in Xq28. Hahn, K.A., Salomons, G.S., Tackels-Horne, D., Wood, T.C., Taylor, H.A., Schroer, R.J., Lubs, H.A., Jakobs, C., Olson, R.L., Holden, K.R., Stevenson, R.E., Schwartz, C.E. Am. J. Hum. Genet. (2002)