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Vázquez-Del Mercado, M et al.

Vázquez-Del Mercado, Muñoz-Valle, Santos, Bernard-Medina, Martínez-Bonilla, Paczka, Ruiz-García, Orozco-Alcalá, Orozco-Barocio, Quezada-Arellano, Gurrola-Díaz, Nuño-González, Best-Aguilera, Chávez-Castellanos, Panduro,

Evaluation of lipid profile, macular toxicity and clinical manifestations according to APO E genotype in systemic lupus erythematosus and rheumatoid arthritis patients treated with chloroquine.

OBJECTIVE: To investigate the effect of APO E gene polymorphism over lipid profile, macular toxicity and clinical manifestations in RA and SLE patients treated with chloroquine. MATERIALS AND METHODS: We studied 45 RA and 29 SLE patients treated with chloroquine who were classified based on the therapeutic regime of chloroquine into three groups: A) Cumulative dose of 100-300 g, B) >300 g and C) Never received chloroquine. Clinical evaluation, fasting lipid profile, visual field testing and stereoscopic photos of the retina were performed. APO E genotype was determined by PCR-RFLP. RESULTS: Reduced apo B levels in RA and SLE according to the cumulative dose of chloroquine 2/3 APO E genotype in a subset of SLE patients were observed. Macular toxicity was independent of both APO E genotype and cumulative chloroquine dose. CONCLUSIONS: Reduced apo B levels were observed associated to chloroquine treatment and 2/3 APO E genotype.[1]

References

Evaluation of lipid profile, macular toxicity and clinical manifestations according to APO E genotype in systemic lupus erythematosus and rheumatoid arthritis patients treated with chloroquine. Vázquez-Del, M.M., Muñoz-Valle, J.F., Santos, A., Bernard-Medina, A.G., Martínez-Bonilla, G., Paczka, J.A., Ruiz-García, H., Orozco-Alcalá, J., Orozco-Barocio, G., Quezada-Arellano, D., Gurrola-Díaz, C., Nuño-González, P., Best-Aguilera, C.R., Chávez-Castellanos, R., Panduro, A. Scand. J. Rheumatol. (2002) [Pubmed]

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