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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Insulin induces PFKFB3 gene expression in HT29 human colon adenocarcinoma cells.

Fructose 2,6-bisphosphate is present at high concentrations in many established lines of transformed cells. It plays a key role in the maintenance of a high glycolytic rate by coupling hormonal and growth factor signals with metabolic demand. The concentration of fructose 2,6-bisphosphate is controlled by the activity of the homodimeric bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2). We report here the PFKFB-3 gene expression control by insulin in the human colon adenocarcinoma HT29 cell line. The incubation of these cells with 1 microM insulin resulted in an increase in the PFK-2 mRNA level after 6 h of treatment, this effect being blocked by actinomycin D. Furthermore, insulin induced ubiquitous PFK-2 protein levels, that were evident after a lag of 3 h and could be inhibited by incubation with cycloheximide.[1]


  1. Insulin induces PFKFB3 gene expression in HT29 human colon adenocarcinoma cells. Riera, L., Manzano, A., Navarro-Sabaté, A., Perales, J.C., Bartrons, R. Biochim. Biophys. Acta (2002) [Pubmed]
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