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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids.

Phloretin is a dihydrochalcone flavonoid that displays a potent antioxidant activity in peroxynitrite scavenging and the inhibition of lipid peroxidation. Comparison with structurally related compounds revealed that the antioxidant pharmacophore of phloretin is 2,6-dihydroxyacetophenone. The potent activity of 2,6-dihydroxyacetophenone is due to stabilisation of its radical via tautomerisation. The antioxidant pharmacophore in the dihydrochalcone phloretin, i.e., the 2,6-dihydroxyacetophenone group, is different from the antioxidant pharmacophores previously reported in flavonoids.[1]

References

  1. The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids. Rezk, B.M., Haenen, G.R., van der Vijgh, W.J., Bast, A. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
 
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