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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism.

A side-effect of treatment with antipsychotic drugs for schizophrenia is increased body fat, which leads to further morbidity and poor adherence to treatment. The 5-hydroxytryptamine 2C receptor (5-HT2C) has been associated with this effect; we aimed to establish whether a genetic polymorphism of the promoter region of this receptor affects weight gain after drug treatment in first-episode patients with schizophrenia. We noted significantly less weight gain in patients with the -759T variant allele (p=0.0003) than in those without this allele, who were more likely to have substantial (>7%) weight gain (p=0.002). We have identified a genetic factor that is associated with antipsychotic drug-induced weight gain.[1]

References

  1. Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism. Reynolds, G.P., Zhang, Z.J., Zhang, X.B. Lancet (2002) [Pubmed]
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