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Doi, K. et al.

Doi, Horiuchi, Uchinami, Tabo, Kimura, Yokomachi, Yoshida, Tanaka,

Hepatic ischemia-reperfusion promotes liver metastasis of colon cancer.

BACKGROUND: The effects of hepatic ischemia/reperfusion (I/R) on liver metastasis have not been fully examined. We examined hepatic I/R and liver metastasis of colorectal cancer in a rat model; we also quantitated expression of E-selectin (ELAM-1) mRNA after I/R. MATERIALS AND METHODS: Rats underwent 30 or 60 min of 70% partial hepatic ischemia. After 60 min of reperfusion, rat colon adenocarcinoma cells (RCN-H4) were inoculated intrasplenically. The number of tumor nodules on the liver surface was determined 3 weeks later. Expression of E-selectin mRNA was determined at 1, 3, and 6 h after ischemia by quantitative RT-PCR. RESULTS: Hepatic I/R promoted liver metastasis of RCN-H4 and induced the expression of E-selectin mRNA in both clamped and unclamped liver lobes. The number of tumor nodules and the expression of E-selectin mRNA after 60 min of ischemia was greater than that after 30 min. CONCLUSIONS: Hepatic I/R, especially with a long duration of ischemia, induces expression of E-selectin and promotes liver metastasis of colon cancer in rats.[1]

References

Hepatic ischemia-reperfusion promotes liver metastasis of colon cancer. Doi, K., Horiuchi, T., Uchinami, M., Tabo, T., Kimura, N., Yokomachi, J., Yoshida, M., Tanaka, K. J. Surg. Res. (2002) [Pubmed]

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