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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Multi-subunit acetyl-CoA carboxylases.

Acetyl-CoA carboxylase ( ACC) catalyses the first committed step of fatty acid synthesis, the carboxylation of acetyl-CoA to malonyl-CoA. Two physically distinct types of enzymes are found in nature. Bacterial and most plant chloroplasts contain a multi-subunit ACC ( MS- ACC) enzyme that is readily dissociated into its component proteins. Mammals, fungi, and plant cytosols contain the second type of ACC, a single large multifunctional polypeptide. This review will focus on the structures, regulation, and enzymatic mechanisms of the bacterial and plant MS-ACCs.[1]


  1. Multi-subunit acetyl-CoA carboxylases. Cronan, J.E., Waldrop, G.L. Prog. Lipid Res. (2002) [Pubmed]
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