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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cystic fibrosis in rhinologic practice.

BACKGROUND: Cystic fibrosis ( CF) is the most common genetic lethal disorder that affects white populations. Chronic rhinosinusitis (CRS) with extensive nasal polyposis is one of the manifestations of CF. METHODS: The aim of this study was to determine the prevalence and extent of CRS in CF patients. RESULTS: The study indicated that the signs and symptoms of CRS were present in all patients with CF and they were more advanced than in the control group. The most severe inflammatory changes in the paranasal sinuses were detected in patients with the dF508 gene mutation type who sufferedfrom CRS for >3 years. CONCLUSIONS: Massive nasal polyposis, dilated base of the nose, mucociliary clearance impairment, and significant radiological changes (frontal and maxillary sinus hypoplasia, bony destruction, and medial bulging of the lateral nasal wall) were identified to be the characteristic signs of the CRS in CF patients.[1]


  1. Cystic fibrosis in rhinologic practice. Krzeski, A., Kapiszewska-Dzedzej, D., Górski, N.P., Jakubczyk, I. American journal of rhinology. (2002) [Pubmed]
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